Kristian Doyle

Kristian Doyle, PhD

Professor, Immunobiology

Professor, Neurology

Professor, Psychology

Professor, BIO5 Institute

Professor, Neurosurgery

Professor, Neuroscience-GIDP

Research Scientist, Arizona Center on Aging

1656 E. Mabel Street

P.O. Box 245221

Tucson, AZ 85724-5221

Medical Research Building
Suite 214

(520) 626-7013

doylekr@arizona.edu

Links

Doyle Lab

Pubmed

Kristian Doyle earned his PhD from Oregon Health & Science University in 2007 developing novel therapeutics for stroke in the laboratory of Dr Mary Stenzel-Poore. Dr Doyle then trained as a Postdoctoral Scholar at Stanford University under the mentorship of Dr Marion Buckwalter researching the role of TGFbeta signaling after stroke and developing a model of post stroke dementia. Dr Doyle started as an Assistant Professor at the University of Arizona in 2013. Dr Doyle was awarded an American Federation of Aging Research Fellowship in 2009, an Anita Roberts Young Scientist Scholarship in 2010, and a K99/R00 faculty transition award from the National Institute of Nursing Research in 2012.

Degrees

PhD: Oregon Health & Science University, 2007
BS: University of Sussex

Work Experience

Stanford University

Publications

Taylor, Stephanie, Mehina, Eslam, White, Emily, et al. Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain. J Neurosci. 2018;38(40):8707-8722. doi:10.1523/JNEUROSCI.0734-18.2018

Doyle, Kristian P, Buckwalter, Marion S. Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia? Brain Behav Immun. Published online January 1, 2016. doi:10.1016/j.bbi.2016.08.009

Nguyen, Thuy-Vi V, Frye, Jennifer B, Zbesko, Jacob C, et al. Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue. Acta Neuropathol Commun. 2016;4(1):100. doi:10.1186/s40478-016-0371-y

Doyle, Kristian P, Quach, Lisa N, Solé, Montse, et al. B-lymphocyte-mediated delayed cognitive impairment following stroke. J Neurosci. 2015;35(5):2133-45. doi:10.1523/JNEUROSCI.4098-14.2015

Doyle, Kristian P, Quach, Lisa N, Arceuil, Helen E D’, Buckwalter, Marion S. Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice. Neurosci Lett. 2015;584:236-40. doi:10.1016/j.neulet.2014.10.041

Cekanaviciute, Egle, Fathali, Nancy, Doyle, Kristian P, Williams, Aaron M, Han, Jullet, Buckwalter, Marion S. Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. 2014;62(8):1227-40. doi:10.1002/glia.22675

Pollak, Julia, Doyle, Kristian P, Mamer, Lauren, Shamloo, Mehrdad, Buckwalter, Marion S. Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model. Brain Behav. 2012;2(5):698-706. doi:10.1002/brb3.77

Csiszar, Anna, Podlutsky, Andrej, Podlutskaya, Natalia, et al. Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci. 2012;67(8):841-52. doi:10.1093/gerona/glr216

Han, Jullet, Pollak, Julia, Yang, Tao, et al. Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke. Stroke. 2012;43(7):1918-24. doi:10.1161/STROKEAHA.111.641878

Doyle, Kristian P, Buckwalter, Marion S. The double-edged sword of inflammation after stroke: what sharpens each edge? Ann Neurol. 2012;71(6):729-31. doi:10.1002/ana.23579

Doyle, Kristian P, Fathali, Nancy, Siddiqui, Mohammad R, Buckwalter, Marion S. Distal hypoxic stroke: a new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit. J Neurosci Methods. 2012;207(1):31-40. doi:10.1016/j.jneumeth.2012.03.003

Bahjat, Frances Rena, Williams-Karnesky, Rebecca L, Kohama, Steven G, et al. Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke. J Cereb Blood Flow Metab. 2011;31(5):1229-42. doi:10.1038/jcbfm.2011.6

Doyle, Kristian P, Cekanaviciute, Egle, Mamer, Lauren E, Buckwalter, Marion S. TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke. J Neuroinflammation. 2010;7:62. doi:10.1186/1742-2094-7-62

West, G Alexander, Golshani, Kiarash J, Doyle, Kristian P, et al. A new model of cortical stroke in the rhesus macaque. J Cereb Blood Flow Metab. 2009;29(6):1175-86. doi:10.1038/jcbfm.2009.43

Doyle, Kristian P, Simon, Roger P, Stenzel-Poore, Mary P. Mechanisms of ischemic brain damage. Neuropharmacology. 2008;55(3):310-8. doi:10.1016/j.neuropharm.2008.01.005

Doyle, Kristian P, Yang, Tao, Lessov, Nikola S, et al. Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke. J Cereb Blood Flow Metab. 2008;28(6):1235-48. doi:10.1038/jcbfm.2008.17

Meller, Robert, Stevens, Susan L, Minami, Manabu, et al. Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab. 2005;25(2):217-25. doi:10.1038/sj.jcbfm.9600022

Doyle, Kristian P, Simon, Roger P, Snyder, Aurelie, Stenzel-Poore, Mary P. Working with GFP in the brain. Biotechniques. 2003;34(3):492-4. doi:10.2144/03343bm08

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