Publications

2018

Deshpande, N. R., J. L. Uhrlaub, S. Sing Way, J. Nikolich-Zugich, and M. S. Kuhns, "A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.", PLoS One, vol. 13, issue 6, pp. e0198354, 2018. PMCID: PMC5986155  PMID: 29864157
Lichauco, K., M. S. Lee, and M. S. Kuhns, "Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.", Immunity, vol. 49, issue 5, pp. 786-788, 2018 11 20. PMID: 30462991
Glassman, C. R., H. L. Parrish, M. S. Lee, and M. S. Kuhns, "Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.", Cell Rep, vol. 22, issue 5, pp. 1263-1275, 2018 Jan 30. PMCID: PMC5813697  PMID: 29386113

2016

Bethune, M. T., M. H. Gee, M. Bunse, M. S. Lee, E. H. Gschweng, M. S. Pagadala, J. Zhou, D. Cheng, J. R. Heath, D. B. Kohn, et al., "Domain-swapped T cell receptors improve the safety of TCR gene therapy.", Elife, vol. 5, 2016 11 08. PMCID: PMC5101000  PMID: 27823582
Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 11, issue 3, pp. e0150876, 2016. PMCID: PMC4773146  PMID: 26930656
Parrish, H. L., N. R. Deshpande, J. Vasic, and M. S. Kuhns, "Functional evidence for TCR-intrinsic specificity for MHCII.", Proc Natl Acad Sci U S A, 2016 Feb 1. PMID: 26831112
Glassman, C. R., H. L. Parrish, N. R. Deshpande, and M. S. Kuhns, "The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.", J Immunol, vol. 196, issue 11, pp. 4713-22, 2016 06 01. PMCID: PMC4875830  PMID: 27183595

2015

Lee, M. S., C. R. Glassman, N. R. Deshpande, H. B. Badgandi, H. L. Parrish, C. Uttamapinant, P. S. Stawski, A. Y. Ting, and M. S. Kuhns, "A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.", Immunity, vol. 43, issue 2, pp. 227-39, 2015 Aug 18. PMCID: PMC4545397  PMID: 26231119
Deshpande, N. R., H. L. Parrish, and M. S. Kuhns, "Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.", Elife, vol. 4, pp. e05949, 2015. PMCID: PMC4501121  PMID: 26173205
Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 10, issue 7, pp. e0132333, 2015. PMCID: PMC4493003  PMID: 26147390

2012

Kuhns, M. S., and M. M. Davis, "TCR Signaling Emerges from the Sum of Many Parts.", Front Immunol, vol. 3, pp. 159, 2012. PMCID: PMC3381686  PMID: 22737151
Zeng, X., Y-L. Wei, J. Huang, E. W. Newell, H. Yu, B. A. Kidd, M. S. Kuhns, R. W. Waters, M. M. Davis, C. T. Weaver, et al., "γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.", Immunity, vol. 37, issue 3, pp. 524-34, 2012 Sep 21. PMCID: PMC3495981  PMID: 22960222

2011

Newell, E. W., L. K. Ely, A. C. Kruse, P. A. Reay, S. N. Rodriguez, A. E. Lin, M. S. Kuhns, C. K Garcia, and M. M. Davis, "Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).", J Immunol, vol. 186, issue 10, pp. 5823-32, 2011 May 15. PMCID: PMC3754796  PMID: 21490152

2010

Kuhns, M. S., A. T. Girvin, L. O. Klein, R. Chen, K. D. C. Jensen, E. W. Newell, J. B. Huppa, B. F. Lillemeier, M. Huse, Y-H. Chien, et al., "Evidence for a functional sidedness to the alphabetaTCR.", Proc Natl Acad Sci U S A, vol. 107, issue 11, pp. 5094-9, 2010 Mar 16. PMCID: PMC2841884  PMID: 20202921

2008

Kuhns, M. S., and M. M. Davis, "The safety on the TCR trigger.", Cell, vol. 135, issue 4, pp. 594-6, 2008 Nov 14. PMCID: PMC2905657  PMID: 19013269

2007

Kuhns, M. S., and M. M. Davis, "Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.", Immunity, vol. 26, issue 3, pp. 357-69, 2007 Mar. PMID: 17368054
Huse, M., L. O. Klein, A. T. Girvin, J. M. Faraj, Q-J. Li, M. S. Kuhns, and M. M. Davis, "Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.", Immunity, vol. 27, issue 1, pp. 76-88, 2007 Jul. PMID: 17629516

2006

Huse, M., B. F. Lillemeier, M. S. Kuhns, D. S. Chen, and M. M. Davis, "T cells use two directionally distinct pathways for cytokine secretion.", Nat Immunol, vol. 7, issue 3, pp. 247-55, 2006 Mar. PMID: 16444260
Kuhns, M. S., M. M. Davis, and C. K Garcia, "Deconstructing the form and function of the TCR/CD3 complex.", Immunity, vol. 24, issue 2, pp. 133-9, 2006 Feb. PMID: 16473826

2002

Egen, J. G., M. S. Kuhns, and J. P. Allison, "CTLA-4: new insights into its biological function and use in tumor immunotherapy.", Nat Immunol, vol. 3, issue 7, pp. 611-8, 2002 Jul. PMID: 12087419

2001

Chambers, C. A., M. S. Kuhns, J. G. Egen, and J. P. Allison, "CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.", Annu Rev Immunol, vol. 19, pp. 565-94, 2001. PMID: 11244047

2000

Kuhns, M. S., V. Epshteyn, R. A. Sobel, and J. P. Allison, "Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.", Proc Natl Acad Sci U S A, vol. 97, issue 23, pp. 12711-6, 2000 Nov 7. PMCID: PMC18829  PMID: 11050166

1999

Chambers, C. A., M. S. Kuhns, and J. P. Allison, "Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.", Proc Natl Acad Sci U S A, vol. 96, issue 15, pp. 8603-8, 1999 Jul 20. PMCID: PMC17563  PMID: 10411922