2024
Lee, M. S., P. J. Tuohy, C. Y. Kim, P. P. Yost, K. Lichauco, H. L. Parrish, K. Van Doorslaer, and M. S. Kuhns, "The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions.", Elife, vol. 12, 2024 Apr 19. PubMed PMCID: PMC11031086 PMID: 38639990
2022
Kim, C. Y., H. L. Parrish, and M. S. Kuhns, "The TCR Cα Domain Regulates Responses to Self-pMHC Class II.", J Immunol, vol. 209, issue 10, pp. 2033-2041, 2022 Nov 15. PubMed PMCID: PMC9643626 PMID: 36426940
Lee, M. S., P. J. Tuohy, C. Y. Kim, K. Lichauco, H. L. Parrish, K. Van Doorslaer, and M. S. Kuhns, "Enhancing and inhibitory motifs regulate CD4 activity.", Elife, vol. 11, 2022 Jul 21. PubMed PMCID: PMC9333989 PMID: 35861317
2020
Kobayashi, S., M. A. Thelin, H. L. Parrish, N. R. Deshpande, M. S. Lee, A. Karimzadeh, M. A. Niewczas, T. Serwold, and M. S. Kuhns, "A biomimetic five-module chimeric antigen receptor (CAR) designed to target and eliminate antigen-specific T cells.", Proc Natl Acad Sci U S A, vol. 117, issue 46, pp. 28950-28959, 2020 Nov 17. PubMed PMCID: PMC7682351 PMID: 33139567
2019
Krummel, M., C. Blish, M. Kuhns, K. Cadwell, A. Oberst, A. Goldrath, M. K Ansel, H. Chi, R. O'Connell, J. E Wherry, et al., "Universal Principled Review: A Community-Driven Method to Improve Peer Review.", Cell, vol. 179, issue 7, pp. 1441-1445, 2019 Dec 12. PubMed PMID: 31835023
2018
Glassman, C. R., H. L. Parrish, M. S. Lee, and M. S. Kuhns, "Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.", Cell Rep, vol. 22, issue 5, pp. 1263-1275, 2018 Jan 30. PubMed PMCID: PMC5813697 PMID: 29386113
Deshpande, N. R., J. L. Uhrlaub, S. Sing Way, J. Nikolich-Zugich, and M. S. Kuhns, "A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.", PLoS One, vol. 13, issue 6, pp. e0198354, 2018. PubMed PMCID: PMC5986155 PMID: 29864157
Lichauco, K., M. S. Lee, and M. S. Kuhns, "Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.", Immunity, vol. 49, issue 5, pp. 786-788, 2018 11 20. PubMed PMID: 30462991
2016
Parrish, H. L., N. R. Deshpande, J. Vasic, and M. S. Kuhns, "Functional evidence for TCR-intrinsic specificity for MHCII.", Proc Natl Acad Sci U S A, 2016 Feb 1. PubMed PMID: 26831112
Glassman, C. R., H. L. Parrish, N. R. Deshpande, and M. S. Kuhns, "The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex.", J Immunol, vol. 196, issue 11, pp. 4713-22, 2016 06 01. PubMed PMCID: PMC4875830 PMID: 27183595
Bethune, M. T., M. H. Gee, M. Bunse, M. S. Lee, E. H. Gschweng, M. S. Pagadala, J. Zhou, D. Cheng, J. R. Heath, D. B. Kohn, et al., "Domain-swapped T cell receptors improve the safety of TCR gene therapy.", Elife, vol. 5, 2016 11 08. PubMed PMCID: PMC5101000 PMID: 27823582
Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 11, issue 3, pp. e0150876, 2016. PubMed PMCID: PMC4773146 PMID: 26930656
2015
Lee, M. S., C. R. Glassman, N. R. Deshpande, H. B. Badgandi, H. L. Parrish, C. Uttamapinant, P. S. Stawski, A. Y. Ting, and M. S. Kuhns, "A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.", Immunity, vol. 43, issue 2, pp. 227-39, 2015 Aug 18. PubMed PMCID: PMC4545397 PMID: 26231119
Deshpande, N. R., H. L. Parrish, and M. S. Kuhns, "Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.", Elife, vol. 4, pp. e05949, 2015 Jul 14. PubMed PMCID: PMC4501121 PMID: 26173205
Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 10, issue 7, pp. e0132333, 2015. PubMed PMCID: PMC4493003 PMID: 26147390
2012
Kuhns, M. S., and M. M. Davis, "TCR Signaling Emerges from the Sum of Many Parts.", Front Immunol, vol. 3, pp. 159, 2012. PubMed PMCID: PMC3381686 PMID: 22737151
Zeng, X., Y-L. Wei, J. Huang, E. W. Newell, H. Yu, B. A. Kidd, M. S. Kuhns, R. W. Waters, M. M. Davis, C. T. Weaver, et al., "γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.", Immunity, vol. 37, issue 3, pp. 524-34, 2012 Sep 21. PubMed PMCID: PMC3495981 PMID: 22960222
2011
Newell, E. W., L. K. Ely, A. C. Kruse, P. A. Reay, S. N. Rodriguez, A. E. Lin, M. S. Kuhns, C. K Garcia, and M. M. Davis, "Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).", J Immunol, vol. 186, issue 10, pp. 5823-32, 2011 May 15. PubMed PMCID: PMC3754796 PMID: 21490152
2010
Kuhns, M. S., A. T. Girvin, L. O. Klein, R. Chen, K. D. C. Jensen, E. W. Newell, J. B. Huppa, B. F. Lillemeier, M. Huse, Y-H. Chien, et al., "Evidence for a functional sidedness to the alphabetaTCR.", Proc Natl Acad Sci U S A, vol. 107, issue 11, pp. 5094-9, 2010 Mar 16. PubMed PMCID: PMC2841884 PMID: 20202921
2008
Kuhns, M. S., and M. M. Davis, "The safety on the TCR trigger.", Cell, vol. 135, issue 4, pp. 594-6, 2008 Nov 14. PubMed PMCID: PMC2905657 PMID: 19013269
2007
Kuhns, M. S., and M. M. Davis, "Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.", Immunity, vol. 26, issue 3, pp. 357-69, 2007 Mar. PubMed PMID: 17368054
Huse, M., L. O. Klein, A. T. Girvin, J. M. Faraj, Q-J. Li, M. S. Kuhns, and M. M. Davis, "Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.", Immunity, vol. 27, issue 1, pp. 76-88, 2007 Jul. PubMed PMID: 17629516
2006
Kuhns, M. S., M. M. Davis, and C. K Garcia, "Deconstructing the form and function of the TCR/CD3 complex.", Immunity, vol. 24, issue 2, pp. 133-9, 2006 Feb. PubMed PMID: 16473826
Huse, M., B. F. Lillemeier, M. S. Kuhns, D. S. Chen, and M. M. Davis, "T cells use two directionally distinct pathways for cytokine secretion.", Nat Immunol, vol. 7, issue 3, pp. 247-55, 2006 Mar. PubMed PMID: 16444260
2002
Egen, J. G., M. S. Kuhns, and J. P. Allison, "CTLA-4: new insights into its biological function and use in tumor immunotherapy.", Nat Immunol, vol. 3, issue 7, pp. 611-8, 2002 Jul. PubMed PMID: 12087419
2001
Chambers, C. A., M. S. Kuhns, J. G. Egen, and J. P. Allison, "CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.", Annu Rev Immunol, vol. 19, pp. 565-94, 2001. PubMed PMID: 11244047
2000
Kuhns, M. S., V. Epshteyn, R. A. Sobel, and J. P. Allison, "Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.", Proc Natl Acad Sci U S A, vol. 97, issue 23, pp. 12711-6, 2000 Nov 7. PubMed PMCID: PMC18829 PMID: 11050166
1999
Chambers, C. A., M. S. Kuhns, and J. P. Allison, "Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.", Proc Natl Acad Sci U S A, vol. 96, issue 15, pp. 8603-8, 1999 Jul 20. PubMed PMCID: PMC17563 PMID: 10411922