Publications

2024

Becktel, D. A., J. B. Frye, E. H. Le, S. A. Whitman, R. G. Schnellmann, H. W. Morrison, and K. P. Doyle, "Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model.", J Lipid Res, vol. 65, issue 9, pp. 100614, 2024 Sep. PMCID: PMC11399596  PMID: 39098585
Bernard, K., J. A. Mota, P. Wene, M. J. Corenblum, J. L. Saez, M. J. Bartlett, L. M Heien, K. P. Doyle, R. Polt, M. Hay, et al., "The angiotensin (1-7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson's disease through modulation of neuroinflammation.", Exp Neurol, vol. 381, pp. 114926, 2024 Nov. PMID: 39153685
Murphy, D. P., D. C. Dickson, A. N. Fatema, N. G. Carrasco, K. P. Doyle, T. P. Trouard, and H. W. Morrison, "Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion.", Physiol Rep, vol. 12, issue 12, pp. e16118, 2024 Jun. PMCID: PMC11194179  PMID: 38923318
Arizanovska, D., C. A. Dallera, O. O. Folorunso, G. F. Bush, J. B. Frye, K. P. Doyle, J. R. Jagid, H. Wolosker, B. A. Monaco, J. Graciolli Cordeiro, et al., "Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes.", bioRxiv, 2024 Aug 14. PMCID: PMC11360988  PMID: 39211262
Maiyo, B. K., S. H. Loppi, H. W. Morrison, and K. P. Doyle, "Assessment and Quantification of Foam Cells and Lipid Droplet-Accumulating Microglia in Mouse Brain Tissue Using BODIPY Staining.", Bio Protoc, vol. 14, issue 21, pp. e5107, 2024 Nov 05. PMCID: PMC11543782  PMID: 39525975

2023

Zbesko, J. C., J. Stokes, D. A. Becktel, and K. P. Doyle, "Targeting foam cell formation to improve recovery from ischemic stroke.", Neurobiol Dis, vol. 181, pp. 106130, 2023 Jun 01. PMID: 37068641
Loppi, S. H., M. A. Tavera-Garcia, D. A. Becktel, B. K. Maiyo, K. E. Johnson, T-V. V. Nguyen, R. G. Schnellmann, and K. P. Doyle, "Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke.", J Cereb Blood Flow Metab, vol. 43, issue 7, pp. 1099-1114, 2023 Jul. PMCID: PMC10291449  PMID: 36772984
Loppi, S. H., M. A. Tavera-Garcia, N. E. Scholpa, B. K. Maiyo, D. A. Becktel, H. W. Morrison, R. G. Schnellmann, and K. P. Doyle, "Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain.", Int J Mol Sci, vol. 24, issue 23, 2023 Nov 23. PMCID: PMC10706318  PMID: 38068955

2022

Pederson, W. P., L. M. Ellerman, E. C. Sandoval, S. Boitano, J. B. Frye, K. P. Doyle, H. L. Brooks, F. Polverino, and J. G. Ledford, "Development of a Novel Mouse Model of Menopause-associated Asthma.", Am J Respir Cell Mol Biol, vol. 67, issue 5, pp. 605-609, 2022 Nov. PMCID: PMC9651199  PMID: 36318015
Dwyer, L. J., A. M. Stowe, K. Doyle, P. Popovich, E. Engler-Chiurazzi, C. LeGuern, M. S. Buckwalter, M. C. Poznansky, and R. F. Sîrbulescu, "The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022.", FASEB J, vol. 36, issue 8, pp. e22459, 2022 Aug. PMCID: PMC9337863  PMID: 35857314
Becktel, D. A., J. C. Zbesko, J. B. Frye, A. G. Chung, M. Hayes, K. Calderon, J. W. Grover, A. Li, F. G. Garcia, M. A. Tavera-Garcia, et al., "Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke", Journal of Neuroscience, vol. Jan 42; 2: 325-348, 2022.

2021

Zbesko, J.C., J.B. Frye, D.A. Becktel, D.K. Gerardo, J. Stokes, K. Calderon, T.V. Nguyen, D. Bhattacharya, and K.P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke", Brain Behavior and Immunity, vol. 91, 2021.
Hoyer-Kimura, C., J.P. Konhilas, H.M. Mansour, R. Polt, K.P. Doyle, D. Billheimer, and M. Hay, "Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia.", Journal of Neuroinflammation, vol. 18(1), 10/2021.
Nguyen, T. V., R. H. Crumpacker, K. E. Calderon, F. G. Garcia, J. C. Zbesko, J. B. Frye, S. Gonzalez, D. A. Becktel, T. Yang, M. A. Tavera-Garcia, et al., "Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery", Journal of Pharmacology and experimental Therapeutics, vol. JPET-AR-2021-000711, 2021.

2020

Bartlett, M. J., A. J. Flores, T. Ye, S. I. Smidt, H. K. Dollish, J. A. Stancati, D. C. Farrell, K. L. Parent, K. P. Doyle, D. G. Besselsen, et al., "Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia.", Exp Neurol, vol. 333, pp. 113413, 2020 Nov. PMCID: PMC7518549  PMID: 32717354

2019

Hay, M., R. Polt, M. L. Heien, T. W. Vanderah, T. M. Largent-Milnes, K. Rodgers, T. Falk, M. J. Bartlett, K. P. Doyle, and J. P. Konhilas, "A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.", J Pharmacol Exp Ther, vol. 369, issue 1, pp. 9-25, 2019 Apr. PMCID: PMC6413771  PMID: 30709867
Doyle, K. P., and M. S. Buckwalter, "Immunological mechanisms in poststroke dementia.", Curr Opin Neurol, 2019 Nov 27. PMID: 31789707

2018

Chung, A. G., J. B. Frye, J. C. Zbesko, E. Constantopoulos, M. Hayes, A. G. Figueroa, D. A. Becktel, A. W Day, J. P. Konhilas, B. S. McKay, et al., "Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PMCID: PMC6223114  PMID: 30417081
Nguyen, T-V. V., M. Hayes, J. C. Zbesko, J. B. Frye, N. R. Congrove, N. P. Belichenko, B. S. McKay, F. M. Longo, and K. P. Doyle, "Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.", Acta Neuropathol Commun, vol. 6, issue 1, pp. 100, 2018 09 24. PMCID: PMC6154927  PMID: 30249297
Taylor, S., E. Mehina, E. White, P. Reeson, K. Yongblah, K. P. Doyle, and C. E. Brown, "Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain.", J Neurosci, vol. 38, issue 40, pp. 8707-8722, 2018 Oct 03. PMID: 30201775
Zbesko, J. C., T-V. V. Nguyen, T. Yang, J. Beischel Frye, O. Hussain, M. Hayes, A. Chung, A. W Day, K. Stepanovic, M. Krumberger, et al., "Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.", Neurobiol Dis, vol. 112, pp. 63-78, 2018 Jan 10. PMID: 29331263

2017

Danilo, C. A., E. Constantopoulos, L. A. McKee, H. Chen, J. A. Regan, Y. Lipovka, S. Lahtinen, L. K. Stenman, T-V. V. Nguyen, K. P. Doyle, et al., "Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.", Benef Microbes, vol. 8, issue 2, pp. 257-269, 2017 Apr 26. PMID: 28409534

2016

Nguyen, T-V. V., J. B. Frye, J. C. Zbesko, K. Stepanovic, M. Hayes, A. Urzua, G. Serrano, T. G. Beach, and K. P. Doyle, "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue.", Acta Neuropathol Commun, vol. 4, issue 1, pp. 100, 2016 Sep 06. PMCID: PMC5011964  PMID: 27600707
Doyle, K. P., and M. S. Buckwalter, "Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?", Brain Behav Immun, 2016 Aug 13. PMCID: PMC5305803  PMID: 27531189

2015

Doyle, K. P., L. N. Quach, M. Solé, R. C. Axtell, T-V. V. Nguyen, G. J. Soler-Llavina, S. Jurado, J. Han, L. Steinman, F. M. Longo, et al., "B-lymphocyte-mediated delayed cognitive impairment following stroke.", J Neurosci, vol. 35, issue 5, pp. 2133-45, 2015 Feb 04. PMCID: PMC4315838  PMID: 25653369
Doyle, K. P., L. N. Quach, H. E. D. ' Arceuil, and M. S. Buckwalter, "Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice.", Neurosci Lett, vol. 584, pp. 236-40, 2015 Jan 01. PMCID: PMC4268374  PMID: 25449870

2014

Cekanaviciute, E., N. Fathali, K. P. Doyle, A. M. Williams, J. Han, and M. S. Buckwalter, "Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice.", Glia, vol. 62, issue 8, pp. 1227-40, 2014 Aug. PMCID: PMC4061255  PMID: 24733756

2012

Pollak, J., K. P. Doyle, L. Mamer, M. Shamloo, and M. S. Buckwalter, "Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.", Brain Behav, vol. 2, issue 5, pp. 698-706, 2012 Sep. PMCID: PMC3489820  PMID: 23139913
Doyle, K. P., and M. S. Buckwalter, "The double-edged sword of inflammation after stroke: what sharpens each edge?", Ann Neurol, vol. 71, issue 6, pp. 729-31, 2012 Jun. PMID: 22718541
Han, J., J. Pollak, T. Yang, M. R. Siddiqui, K. P. Doyle, K. Taravosh-Lahn, E. Cekanaviciute, A. Han, J. Z. Goodman, B. Jones, et al., "Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke.", Stroke, vol. 43, issue 7, pp. 1918-24, 2012 Jul. PMCID: PMC3383889  PMID: 22535263
Doyle, K. P., N. Fathali, M. R. Siddiqui, and M. S. Buckwalter, "Distal hypoxic stroke: a new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit.", J Neurosci Methods, vol. 207, issue 1, pp. 31-40, 2012 May 30. PMCID: PMC3348433  PMID: 22465679
Csiszar, A., A. Podlutsky, N. Podlutskaya, W. E. Sonntag, S. Z. Merlin, E. E. R. Philipp, K. Doyle, A. Davila, F. A. Recchia, P. Ballabh, et al., "Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?", J Gerontol A Biol Sci Med Sci, vol. 67, issue 8, pp. 841-52, 2012 Aug. PMCID: PMC3403864  PMID: 22219516

2011

Bahjat, F. Rena, R. L. Williams-Karnesky, S. G. Kohama, A. G West, K. P. Doyle, M. D. Spector, T. R. Hobbs, and M. P. Stenzel-Poore, "Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke.", J Cereb Blood Flow Metab, vol. 31, issue 5, pp. 1229-42, 2011 May. PMCID: PMC3099644  PMID: 21285967

2010

Doyle, K. P., E. Cekanaviciute, L. E. Mamer, and M. S. Buckwalter, "TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke.", J Neuroinflammation, vol. 7, pp. 62, 2010 Oct 11. PMCID: PMC2958905  PMID: 20937129

2009

G West, A., K. J. Golshani, K. P. Doyle, N. S. Lessov, T. R. Hobbs, S. G. Kohama, M. M. Pike, C. D. Kroenke, M. R. Grafe, M. D. Spector, et al., "A new model of cortical stroke in the rhesus macaque.", J Cereb Blood Flow Metab, vol. 29, issue 6, pp. 1175-86, 2009 Jun. PMCID: PMC2828874  PMID: 19384334

2008

Doyle, K. P., R. P. Simon, and M. P. Stenzel-Poore, "Mechanisms of ischemic brain damage.", Neuropharmacology, vol. 55, issue 3, pp. 310-8, 2008 Sep. PMCID: PMC2603601  PMID: 18308346
Doyle, K. P., T. Yang, N. S. Lessov, T. M. Ciesielski, S. L. Stevens, R. P. Simon, J. S. King, and M. P. Stenzel-Poore, "Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke.", J Cereb Blood Flow Metab, vol. 28, issue 6, pp. 1235-48, 2008 Jun. PMCID: PMC6015748  PMID: 18364727

2005

Meller, R., S. L. Stevens, M. Minami, J. A. Cameron, S. King, H. Rosenzweig, K. Doyle, N. S. Lessov, R. P. Simon, and M. P. Stenzel-Poore, "Neuroprotection by osteopontin in stroke.", J Cereb Blood Flow Metab, vol. 25, issue 2, pp. 217-25, 2005 Feb. PMID: 15678124

2003

Doyle, K. P., R. P. Simon, A. Snyder, and M. P. Stenzel-Poore, "Working with GFP in the brain.", Biotechniques, vol. 34, issue 3, pp. 492-4, 2003 Mar. PMID: 12669698