2026
Becktel, D. A., E. H. Le, J. B. Frye, S. A. Whitman, R. G. Schnellmann, and K. P. Doyle, "2-Hydroxypropyl-β-cyclodextrin accesses acute and subacute infarcts in a mouse model of ischemic stroke.", Fluids Barriers CNS, 2026 Jan 28. PubMed PMID: 41606744
2025
Peterson, I. L., N. E. Scholpa, K. J. Bachtle, J. B. Frye, S. H. Loppi, A. D. Thompson, K. Doyle, T. Marie Largent-Milnes, and R. G. Schnellmann, "Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice.", J Pharmacol Exp Ther, vol. 392, issue 2, pp. 100015, 2025 Feb. PubMed PMCID: PMC12571147 PMID: 40023611
Becktel, D. A., J. B. Frye, E. H. Le, R. G. Schnellmann, and K. P. Doyle, "Plasma Biomarker Profiling of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Treatment in an Aged Mouse Model of Ischemic Stroke.", Int J Mol Sci, vol. 26, issue 22, 2025 Nov 07. PubMed PMCID: PMC12653018 PMID: 41303302
Arizanovska, D., G. F. Bush Iii, C. A. Dallera, O. O. Folorunso, J. B. Frye, K. P. Doyle, J. R. Jagid, H. Wolosker, B. A. Monaco, J. Graciolli Cordeiro, et al., "Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes.", Brain, 2025 Aug 12. PubMed PMID: 40796363
Bartlett, M. J., R. P. Erickson, J. Frye, K. P. Doyle, P. W. Pires, and M. H. Witte, "Manual lymph drainage massage of the head and neck improves cognition and reduces pathological biomarkers in the mouse model of Alzheimers disease.", bioRxiv, 2025 Aug 12. PubMed PMCID: PMC12363786 PMID: 40832216
Brezzo, G., K. A. Zera, D. E. Straus, J. E. Goertz, S. H. Loppi, R. R. Crumpacker, J. B. Frye, D. A. Becktel, M. Isabel Cuartero, A. García Culebras, et al., "Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study.", J Cereb Blood Flow Metab, pp. 271678X251400241, 2025 Dec 07. PubMed PMCID: PMC12685733 PMID: 41355059
Hashemi, E., I. N. Srivastava, A. Aguirre, E. T. Yoseph, E. Kaushal, A. Awani, J. K. Ryu, K. Akassoglou, S. Talebian, P. Chu, et al., "A Novel Mouse Model for Cerebral Inflammatory Demyelination in X-Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets.", Ann Neurol, vol. 97, issue 2, pp. 296-312, 2025 Feb. PubMed PMCID: PMC11747894 PMID: 39467011
2024
Becktel, D. A., J. B. Frye, E. H. Le, S. A. Whitman, R. G. Schnellmann, H. W. Morrison, and K. P. Doyle, "Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model.", J Lipid Res, vol. 65, issue 9, pp. 100614, 2024 Sep. PubMed PMCID: PMC11399596 PMID: 39098585
Bernard, K., J. A. Mota, P. Wene, M. J. Corenblum, J. L. Saez, M. J. Bartlett, L. M Heien, K. P. Doyle, R. Polt, M. Hay, et al., "The angiotensin (1-7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson's disease through modulation of neuroinflammation.", Exp Neurol, vol. 381, pp. 114926, 2024 Nov. PubMed PMID: 39153685
Murphy, D. P., D. C. Dickson, A. N. Fatema, N. G. Carrasco, K. P. Doyle, T. P. Trouard, and H. W. Morrison, "Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion.", Physiol Rep, vol. 12, issue 12, pp. e16118, 2024 Jun. PubMed PMCID: PMC11194179 PMID: 38923318
Arizanovska, D., C. A. Dallera, O. O. Folorunso, G. F. Bush, J. B. Frye, K. P. Doyle, J. R. Jagid, H. Wolosker, B. A. Monaco, J. Graciolli Cordeiro, et al., "Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes.", bioRxiv, 2024 Aug 14. PubMed PMCID: PMC11360988 PMID: 39211262
Maiyo, B. K., S. H. Loppi, H. W. Morrison, and K. P. Doyle, "Assessment and Quantification of Foam Cells and Lipid Droplet-Accumulating Microglia in Mouse Brain Tissue Using BODIPY Staining.", Bio Protoc, vol. 14, issue 21, pp. e5107, 2024 Nov 05. PubMed PMCID: PMC11543782 PMID: 39525975
2023
Zbesko, J. C., J. Stokes, D. A. Becktel, and K. P. Doyle, "Targeting foam cell formation to improve recovery from ischemic stroke.", Neurobiol Dis, vol. 181, pp. 106130, 2023 Jun 01. PubMed PMID: 37068641
Loppi, S. H., M. A. Tavera-Garcia, D. A. Becktel, B. K. Maiyo, K. E. Johnson, T-V. V. Nguyen, R. G. Schnellmann, and K. P. Doyle, "Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke.", J Cereb Blood Flow Metab, vol. 43, issue 7, pp. 1099-1114, 2023 Jul. PubMed PMCID: PMC10291449 PMID: 36772984
Loppi, S. H., M. A. Tavera-Garcia, N. E. Scholpa, B. K. Maiyo, D. A. Becktel, H. W. Morrison, R. G. Schnellmann, and K. P. Doyle, "Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain.", Int J Mol Sci, vol. 24, issue 23, 2023 Nov 23. PubMed PMCID: PMC10706318 PMID: 38068955
2022
Pederson, W. P., L. M. Ellerman, E. C. Sandoval, S. Boitano, J. B. Frye, K. P. Doyle, H. L. Brooks, F. Polverino, and J. G. Ledford, "Development of a Novel Mouse Model of Menopause-associated Asthma.", Am J Respir Cell Mol Biol, vol. 67, issue 5, pp. 605-609, 2022 Nov. PubMed PMCID: PMC9651199 PMID: 36318015
Dwyer, L. J., A. M. Stowe, K. Doyle, P. Popovich, E. Engler-Chiurazzi, C. LeGuern, M. S. Buckwalter, M. C. Poznansky, and R. F. Sîrbulescu, "The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022.", FASEB J, vol. 36, issue 8, pp. e22459, 2022 Aug. PubMed PMCID: PMC9337863 PMID: 35857314
Becktel, D. A., J. C. Zbesko, J. B. Frye, A. G. Chung, M. Hayes, K. Calderon, J. W. Grover, A. Li, F. G. Garcia, M. A. Tavera-Garcia, et al., "Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke", Journal of Neuroscience, vol. Jan 42; 2: 325-348, 2022.
2021
Zbesko, J.C., J.B. Frye, D.A. Becktel, D.K. Gerardo, J. Stokes, K. Calderon, T.V. Nguyen, D. Bhattacharya, and K.P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke", Brain Behavior and Immunity, vol. 91, 2021.
Hoyer-Kimura, C., J.P. Konhilas, H.M. Mansour, R. Polt, K.P. Doyle, D. Billheimer, and M. Hay, "Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia.", Journal of Neuroinflammation, vol. 18(1), 10/2021.
Nguyen, T. V., R. H. Crumpacker, K. E. Calderon, F. G. Garcia, J. C. Zbesko, J. B. Frye, S. Gonzalez, D. A. Becktel, T. Yang, M. A. Tavera-Garcia, et al., "Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery", Journal of Pharmacology and experimental Therapeutics, vol. JPET-AR-2021-000711, 2021.
2020
Bartlett, M. J., A. J. Flores, T. Ye, S. I. Smidt, H. K. Dollish, J. A. Stancati, D. C. Farrell, K. L. Parent, K. P. Doyle, D. G. Besselsen, et al., "Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia.", Exp Neurol, vol. 333, pp. 113413, 2020 Nov. PubMed PMCID: PMC7518549 PMID: 32717354
2019
Hay, M., R. Polt, M. L. Heien, T. W. Vanderah, T. M. Largent-Milnes, K. Rodgers, T. Falk, M. J. Bartlett, K. P. Doyle, and J. P. Konhilas, "A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.", J Pharmacol Exp Ther, vol. 369, issue 1, pp. 9-25, 2019 Apr. PubMed PMCID: PMC6413771 PMID: 30709867
Doyle, K. P., and M. S. Buckwalter, "Immunological mechanisms in poststroke dementia.", Curr Opin Neurol, 2019 Nov 27. PubMed PMID: 31789707
2018
Chung, A. G., J. B. Frye, J. C. Zbesko, E. Constantopoulos, M. Hayes, A. G. Figueroa, D. A. Becktel, A. W Day, J. P. Konhilas, B. S. McKay, et al., "Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PubMed PMCID: PMC6223114 PMID: 30417081
Nguyen, T-V. V., M. Hayes, J. C. Zbesko, J. B. Frye, N. R. Congrove, N. P. Belichenko, B. S. McKay, F. M. Longo, and K. P. Doyle, "Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.", Acta Neuropathol Commun, vol. 6, issue 1, pp. 100, 2018 09 24. PubMed PMCID: PMC6154927 PMID: 30249297
Taylor, S., E. Mehina, E. White, P. Reeson, K. Yongblah, K. P. Doyle, and C. E. Brown, "Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain.", J Neurosci, vol. 38, issue 40, pp. 8707-8722, 2018 Oct 03. PubMed PMID: 30201775
Zbesko, J. C., T-V. V. Nguyen, T. Yang, J. Beischel Frye, O. Hussain, M. Hayes, A. Chung, A. W Day, K. Stepanovic, M. Krumberger, et al., "Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.", Neurobiol Dis, vol. 112, pp. 63-78, 2018 Jan 10. PubMed PMID: 29331263
2017
Danilo, C. A., E. Constantopoulos, L. A. McKee, H. Chen, J. A. Regan, Y. Lipovka, S. Lahtinen, L. K. Stenman, T-V. V. Nguyen, K. P. Doyle, et al., "Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.", Benef Microbes, vol. 8, issue 2, pp. 257-269, 2017 Apr 26. PubMed PMID: 28409534
2016
Nguyen, T-V. V., J. B. Frye, J. C. Zbesko, K. Stepanovic, M. Hayes, A. Urzua, G. Serrano, T. G. Beach, and K. P. Doyle, "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue.", Acta Neuropathol Commun, vol. 4, issue 1, pp. 100, 2016 Sep 06. PubMed PMCID: PMC5011964 PMID: 27600707
Doyle, K. P., and M. S. Buckwalter, "Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?", Brain Behav Immun, 2016 Aug 13. PubMed PMCID: PMC5305803 PMID: 27531189
2015
Doyle, K. P., L. N. Quach, M. Solé, R. C. Axtell, T-V. V. Nguyen, G. J. Soler-Llavina, S. Jurado, J. Han, L. Steinman, F. M. Longo, et al., "B-lymphocyte-mediated delayed cognitive impairment following stroke.", J Neurosci, vol. 35, issue 5, pp. 2133-45, 2015 Feb 04. PubMed PMCID: PMC4315838 PMID: 25653369
Doyle, K. P., L. N. Quach, H. E. D. ' Arceuil, and M. S. Buckwalter, "Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice.", Neurosci Lett, vol. 584, pp. 236-40, 2015 Jan 01. PubMed PMCID: PMC4268374 PMID: 25449870
2014
Cekanaviciute, E., N. Fathali, K. P. Doyle, A. M. Williams, J. Han, and M. S. Buckwalter, "Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice.", Glia, vol. 62, issue 8, pp. 1227-40, 2014 Aug. PubMed PMCID: PMC4061255 PMID: 24733756
2012
Pollak, J., K. P. Doyle, L. Mamer, M. Shamloo, and M. S. Buckwalter, "Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.", Brain Behav, vol. 2, issue 5, pp. 698-706, 2012 Sep. PubMed PMCID: PMC3489820 PMID: 23139913
Doyle, K. P., and M. S. Buckwalter, "The double-edged sword of inflammation after stroke: what sharpens each edge?", Ann Neurol, vol. 71, issue 6, pp. 729-31, 2012 Jun. PubMed PMID: 22718541
Han, J., J. Pollak, T. Yang, M. R. Siddiqui, K. P. Doyle, K. Taravosh-Lahn, E. Cekanaviciute, A. Han, J. Z. Goodman, B. Jones, et al., "Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke.", Stroke, vol. 43, issue 7, pp. 1918-24, 2012 Jul. PubMed PMCID: PMC3383889 PMID: 22535263
Doyle, K. P., N. Fathali, M. R. Siddiqui, and M. S. Buckwalter, "Distal hypoxic stroke: a new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit.", J Neurosci Methods, vol. 207, issue 1, pp. 31-40, 2012 May 30. PubMed PMCID: PMC3348433 PMID: 22465679
Csiszar, A., A. Podlutsky, N. Podlutskaya, W. E. Sonntag, S. Z. Merlin, E. E. R. Philipp, K. Doyle, A. Davila, F. A. Recchia, P. Ballabh, et al., "Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?", J Gerontol A Biol Sci Med Sci, vol. 67, issue 8, pp. 841-52, 2012 Aug. PubMed PMCID: PMC3403864 PMID: 22219516
2011
Bahjat, F. Rena, R. L. Williams-Karnesky, S. G. Kohama, A. G West, K. P. Doyle, M. D. Spector, T. R. Hobbs, and M. P. Stenzel-Poore, "Proof of concept: pharmacological preconditioning with a Toll-like receptor agonist protects against cerebrovascular injury in a primate model of stroke.", J Cereb Blood Flow Metab, vol. 31, issue 5, pp. 1229-42, 2011 May. PubMed PMCID: PMC3099644 PMID: 21285967
2010
Doyle, K. P., E. Cekanaviciute, L. E. Mamer, and M. S. Buckwalter, "TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke.", J Neuroinflammation, vol. 7, pp. 62, 2010 Oct 11. PubMed PMCID: PMC2958905 PMID: 20937129
2009
G West, A., K. J. Golshani, K. P. Doyle, N. S. Lessov, T. R. Hobbs, S. G. Kohama, M. M. Pike, C. D. Kroenke, M. R. Grafe, M. D. Spector, et al., "A new model of cortical stroke in the rhesus macaque.", J Cereb Blood Flow Metab, vol. 29, issue 6, pp. 1175-86, 2009 Jun. PubMed PMCID: PMC2828874 PMID: 19384334
2008
Doyle, K. P., R. P. Simon, and M. P. Stenzel-Poore, "Mechanisms of ischemic brain damage.", Neuropharmacology, vol. 55, issue 3, pp. 310-8, 2008 Sep. PubMed PMCID: PMC2603601 PMID: 18308346
Doyle, K. P., T. Yang, N. S. Lessov, T. M. Ciesielski, S. L. Stevens, R. P. Simon, J. S. King, and M. P. Stenzel-Poore, "Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke.", J Cereb Blood Flow Metab, vol. 28, issue 6, pp. 1235-48, 2008 Jun. PubMed PMCID: PMC6015748 PMID: 18364727
2005
Meller, R., S. L. Stevens, M. Minami, J. A. Cameron, S. King, H. Rosenzweig, K. Doyle, N. S. Lessov, R. P. Simon, and M. P. Stenzel-Poore, "Neuroprotection by osteopontin in stroke.", J Cereb Blood Flow Metab, vol. 25, issue 2, pp. 217-25, 2005 Feb. PubMed PMID: 15678124
2003
Doyle, K. P., R. P. Simon, A. Snyder, and M. P. Stenzel-Poore, "Working with GFP in the brain.", Biotechniques, vol. 34, issue 3, pp. 492-4, 2003 Mar. PubMed PMID: 12669698