Publications

2024

Merritt, E. F., J. A. Kochanowsky, P. Hervé, A. A. Watson, and A. A. Koshy, "Toxoplasma type II effector GRA15 has limited influence in vivo.", PLoS One, vol. 19, issue 3, pp. e0300764, 2024. PMCID: PMC10980211  PMID: 38551902

2023

Kochanowsky, J. A., S. Chandrasekaran, J. R. Sanchez, K. K. Thomas, and A. A. Koshy, "ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons.", PLoS Pathog, vol. 19, issue 4, pp. e1011347, 2023 Apr. PMCID: PMC10138205  PMID: 37068104
Butterworth, S., K. Kordova, S. Chandrasekaran, K. K. Thomas, F. Torelli, E. J. Lockyer, A. Edwards, R. Goldstone, A. A. Koshy, and M. Treeck, "High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription.", Cell Host Microbe, vol. 31, issue 10, pp. 1748-1762.e8, 2023 Oct 11. PMID: 37827122
M Licon, H., C. J. Giuliano, A. W. Chan, S. Chakladar, J. N. Eberhard, L. A. Shallberg, S. Chandrasekaran, B. S. Waldman, A. A. Koshy, C. A. Hunter, et al., "A positive feedback loop controls Toxoplasma chronic differentiation.", Nat Microbiol, vol. 8, issue 5, pp. 889-904, 2023 May. PMCID: PMC10520893  PMID: 37081202

2020

Chen, L., D. A. Christian, J. A. Kochanowsky, A. T. Phan, J. T. Clark, S. Wang, C. Berry, J. Oh, X. Chen, D. S. Roos, et al., "The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.", J Exp Med, vol. 217, issue 3, 2020 Mar 02. PMCID: PMC7062521  PMID: 31961916
McGovern, K. E., C. M. Cabral, H. W. Morrison, and A. A. Koshy, "Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory.", Sci Rep, vol. 10, issue 1, pp. 7979, 2020 May 14. PMCID: PMC7224383  PMID: 32409672
Patell, R., T. Bogue, P. Bindal, A. Koshy, M. Merrill, W. C. Aird, K. A. Bauer, and J. I. Zwicker, "Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19.", J Thromb Haemost, 2020 Jul 21. PMCID: PMC7405046  PMID: 32692862
Johnson, H. J., and A. A. Koshy, "Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?", mBio, vol. 11, issue 2, 2020 03 17. PMCID: PMC7078474  PMID: 32184245
Patell, R., A. M. Khan, T. Bogue, M. Merrill, A. Koshy, P. Bindal, R. Joyce, W. C. Aird, D. Neuberg, K. A. Bauer, et al., "Heparin induced thrombocytopenia antibodies in Covid-19.", Am J Hematol, 2020 Jul 13. PMCID: PMC7405086  PMID: 32658337
Merritt, E. F., H. J. Johnson, Z. Sheen Wong, A. S. Buntzman, A. C. Conklin, C. M. Cabral, C. E. Romanoski, J. P. Boyle, and A. A. Koshy, "Transcriptional Profiling Suggests T Cells Cluster around Neurons Injected with Toxoplasma gondii Proteins.", mSphere, vol. 5, issue 5, 2020 Sep 02. PMCID: PMC7471001  PMID: 32878927

2018

Mendez, O. A., C. J. Potter, M. Valdez, T. Bello, T. P. Trouard, and A. A. Koshy, "Semi-automated quantification and neuroanatomical mapping of heterogeneous cell populations.", J Neurosci Methods, vol. 305, pp. 98-104, 2018 Jul 15. PMID: 29782884
Kochanowsky, J. A., and A. A. Koshy, "Toxoplasma gondii.", Curr Biol, vol. 28, issue 14, pp. R770-R771, 2018 Jul 23. PMID: 30040931
Parker, S. S., A. Moutal, S. Cai, S. Chandrasekaran, M. R. Roman, A. A. Koshy, R. Khanna, K. E. Zinsmaier, and G. Mouneimne, "High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PMCID: PMC6158653  PMID: 30263951

2017

Mendez, O. A., and A. A. Koshy, "Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system.", PLoS Pathog, vol. 13, issue 7, pp. e1006351, 2017 Jul. PMCID: PMC5519211  PMID: 28727854
Cabral, C. M., K. E. McGovern, W. R. MacDonald, J. Franco, and A. A. Koshy, "Dissecting Amyloid Beta Deposition Using Distinct Strains of the Neurotropic Parasite Toxoplasma gondii as a Novel Tool.", ASN Neuro, vol. 9, issue 4, pp. 1759091417724915, 2017 Jul-Aug. PMCID: PMC5565021  PMID: 28817954

2016

Cabral, C. M., S. Tuladhar, H. K. Dietrich, E. Nguyen, W. R. MacDonald, T. Trivedi, A. Devineni, and A. A. Koshy, "Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii.", PLoS Pathog, vol. 12, issue 2, pp. e1005447, 2016 Feb. PMCID: PMC4760770  PMID: 26895155
Hidano, S., L. M. Randall, L. Dawson, H. K. Dietrich, C. Konradt, P. J. Klover, B. John, T. H. Harris, Q. Fang, B. Turek, et al., "STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.", MBio, vol. 7, issue 6, 2016 Nov 08. PMCID: PMC5101356  PMID: 27834206
Konradt, C., N. Ueno, D. A. Christian, J. H. Delong, G. Harms Pritchard, J. Herz, D. J. Bzik, A. A. Koshy, D. B. McGavern, M. B. Lodoen, et al., "Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system.", Nat Microbiol, vol. 1, pp. 16001, 2016 Feb 15. PMCID: PMC4966557  PMID: 27572166

2014

Han, S-J., H. J. Melichar, J. L. Coombes, S. Wei Chan, A. A. Koshy, J. C. Boothroyd, G. M. Barton, and E. A. Robey, "Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.", Immunol Cell Biol, vol. 92, issue 10, pp. 872-81, 2014 Nov. PMCID: PMC4245188  PMID: 25155465
Koshy, A. A., and C. M. Cabral, "3-D imaging and analysis of neurons infected in vivo with Toxoplasma gondii.", J Vis Exp, issue 94, 2014. PMCID: PMC4362681  PMID: 25549001
Cekanaviciute, E., H. K. Dietrich, R. C. Axtell, A. M. Williams, R. Egusquiza, K. M. Wai, A. A. Koshy, and M. S. Buckwalter, "Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.", J Immunol, vol. 193, issue 1, pp. 139-49, 2014 Jul 1. PMCID: PMC4075480  PMID: 24860191
Christian, D. A., A. A. Koshy, M. A. Reuter, M. R. Betts, J. C. Boothroyd, and C. A. Hunter, "Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.", Infect Immun, vol. 82, issue 10, pp. 4056-67, 2014 Oct. PMCID: PMC4187868  PMID: 25024368
Blader, I. J., and A. A. Koshy, "Toxoplasma gondii development of its replicative niche: in its host cell and beyond.", Eukaryot Cell, vol. 13, issue 8, pp. 965-76, 2014 Aug. PMCID: PMC4135789  PMID: 24951442

2013

Caffaro, C. E., A. A. Koshy, L. Liu, G. M. Zeiner, C. B. Hirschberg, and J. C. Boothroyd, "A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites.", PLoS Pathog, vol. 9, issue 5, pp. e1003331, 2013. PMCID: PMC3642066  PMID: 23658519
Coombes, J. L., B. A. Charsar, S-J. Han, J. Halkias, S. Wei Chan, A. A. Koshy, B. Striepen, and E. A. Robey, "Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread.", Proc Natl Acad Sci U S A, vol. 110, issue 21, pp. E1913-22, 2013 May 21. PMCID: PMC3666704  PMID: 23650399

2012

Koshy, A. A., H. K. Dietrich, D. A. Christian, J. H. Melehani, A. J. Shastri, C. A. Hunter, and J. C. Boothroyd, "Toxoplasma co-opts host cells it does not invade.", PLoS Pathog, vol. 8, issue 7, pp. e1002825, 2012. PMCID: PMC3406079  PMID: 22910631

2010

Koshy, A. A., A. E. Fouts, M. B. Lodoen, O. Alkan, H. M. Blau, and J. C. Boothroyd, "Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions.", Nat Methods, vol. 7, issue 4, pp. 307-9, 2010 Apr. PMCID: PMC2850821  PMID: 20208532