Koshy Lab Publications

2025

Eberhard, J. N., L. A. Shallberg, A. Winn, S. Chandrasekaran, C. J. Giuliano, E. F. Merritt, E. Willis, C. Konradt, D. A. Christian, D. L. Aldridge, et al., "Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii.", Nat Microbiol, vol. 10, issue 4, pp. 992-1005, 2025 Apr. PubMed PMCID: PMC11964939 PMID: 40148566

Johnson, H. J., J. A. Kochanowsky, S. Chandrasekaran, C. A. Hunter, D. P. Beiting, and A. A. Koshy, "Defining neuronal responses to the neurotropic parasite .", mSphere, vol. 10, issue 6, pp. e0021625, 2025 Jun 25. PubMed PMCID: PMC12188731 PMID: 40444956

Orchanian, S. B., S. Zolog, J. Tomasello, R. Malik, J-H. Shin, A. A. Koshy, and M. B. Lodoen, "parasites induce a localized myeloid cell immune response surrounding parasites in the brain during acute infection.", mBio, vol. 16, issue 7, pp. e0081025, 2025 Jul 09. PubMed PMCID: PMC12239593 PMID: 40492741

Massmann, M. D., S. M. Reilly, A. A. Koshy, and J. P. Boyle, "Toxoplasma gondii and the Brain: Frenemies? Or Just Outright Foes?", J Pediatric Infect Dis Soc, vol. 14, issue 8, 2025 Aug 27. PubMed PMCID: PMC12395554 PMID: 40879422

2024

Merritt, E. F., J. A. Kochanowsky, P. Hervé, A. A. Watson, and A. A. Koshy, "Toxoplasma type II effector GRA15 has limited influence in vivo.", PLoS One, vol. 19, issue 3, pp. e0300764, 2024. PubMed PMCID: PMC10980211 PMID: 38551902

2023

M Licon, H., C. J. Giuliano, A. W. Chan, S. Chakladar, J. N. Eberhard, L. A. Shallberg, S. Chandrasekaran, B. S. Waldman, A. A. Koshy, C. A. Hunter, et al., "A positive feedback loop controls Toxoplasma chronic differentiation.", Nat Microbiol, vol. 8, issue 5, pp. 889-904, 2023 May. PubMed PMCID: PMC10520893 PMID: 37081202

Kochanowsky, J. A., S. Chandrasekaran, J. R. Sanchez, K. K. Thomas, and A. A. Koshy, "ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons.", PLoS Pathog, vol. 19, issue 4, pp. e1011347, 2023 Apr. PubMed PMCID: PMC10138205 PMID: 37068104

Butterworth, S., K. Kordova, S. Chandrasekaran, K. K. Thomas, F. Torelli, E. J. Lockyer, A. Edwards, R. Goldstone, A. A. Koshy, and M. Treeck, "High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription.", Cell Host Microbe, vol. 31, issue 10, pp. 1748-1762.e8, 2023 Oct 11. PubMed PMID: 37827122

2020

Patell, R., A. M. Khan, T. Bogue, M. Merrill, A. Koshy, P. Bindal, R. Joyce, W. C. Aird, D. Neuberg, K. A. Bauer, et al., "Heparin induced thrombocytopenia antibodies in Covid-19.", Am J Hematol, 2020 Jul 13. PubMed PMCID: PMC7405086 PMID: 32658337

Merritt, E. F., H. J. Johnson, Z. Sheen Wong, A. S. Buntzman, A. C. Conklin, C. M. Cabral, C. E. Romanoski, J. P. Boyle, and A. A. Koshy, "Transcriptional Profiling Suggests T Cells Cluster around Neurons Injected with Toxoplasma gondii Proteins.", mSphere, vol. 5, issue 5, 2020 Sep 02. PubMed PMCID: PMC7471001 PMID: 32878927

Chen, L., D. A. Christian, J. A. Kochanowsky, A. T. Phan, J. T. Clark, S. Wang, C. Berry, J. Oh, X. Chen, D. S. Roos, et al., "The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.", J Exp Med, vol. 217, issue 3, 2020 Mar 02. PubMed PMCID: PMC7062521 PMID: 31961916

McGovern, K. E., C. M. Cabral, H. W. Morrison, and A. A. Koshy, "Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory.", Sci Rep, vol. 10, issue 1, pp. 7979, 2020 May 14. PubMed PMCID: PMC7224383 PMID: 32409672

Patell, R., T. Bogue, P. Bindal, A. Koshy, M. Merrill, W. C. Aird, K. A. Bauer, and J. I. Zwicker, "Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID-19.", J Thromb Haemost, 2020 Jul 21. PubMed PMCID: PMC7405046 PMID: 32692862

Johnson, H. J., and A. A. Koshy, "Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?", mBio, vol. 11, issue 2, 2020 03 17. PubMed PMCID: PMC7078474 PMID: 32184245

2018

Mendez, O. A., C. J. Potter, M. Valdez, T. Bello, T. P. Trouard, and A. A. Koshy, "Semi-automated quantification and neuroanatomical mapping of heterogeneous cell populations.", J Neurosci Methods, vol. 305, pp. 98-104, 2018 Jul 15. PubMed PMID: 29782884

Kochanowsky, J. A., and A. A. Koshy, "Toxoplasma gondii.", Curr Biol, vol. 28, issue 14, pp. R770-R771, 2018 Jul 23. PubMed PMID: 30040931

Parker, S. S., A. Moutal, S. Cai, S. Chandrasekaran, M. R. Roman, A. A. Koshy, R. Khanna, K. E. Zinsmaier, and G. Mouneimne, "High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PubMed PMCID: PMC6158653 PMID: 30263951

2017

Cabral, C. M., K. E. McGovern, W. R. MacDonald, J. Franco, and A. A. Koshy, "Dissecting Amyloid Beta Deposition Using Distinct Strains of the Neurotropic Parasite Toxoplasma gondii as a Novel Tool.", ASN Neuro, vol. 9, issue 4, pp. 1759091417724915, 2017 Jul-Aug. PubMed PMCID: PMC5565021 PMID: 28817954

Mendez, O. A., and A. A. Koshy, "Toxoplasma gondii: Entry, association, and physiological influence on the central nervous system.", PLoS Pathog, vol. 13, issue 7, pp. e1006351, 2017 Jul. PubMed PMCID: PMC5519211 PMID: 28727854

2016

Konradt, C., N. Ueno, D. A. Christian, J. H. Delong, G. Harms Pritchard, J. Herz, D. J. Bzik, A. A. Koshy, D. B. McGavern, M. B. Lodoen, et al., "Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system.", Nat Microbiol, vol. 1, pp. 16001, 2016 Feb 15. PubMed PMCID: PMC4966557 PMID: 27572166

Cabral, C. M., S. Tuladhar, H. K. Dietrich, E. Nguyen, W. R. MacDonald, T. Trivedi, A. Devineni, and A. A. Koshy, "Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii.", PLoS Pathog, vol. 12, issue 2, pp. e1005447, 2016 Feb. PubMed PMCID: PMC4760770 PMID: 26895155

Hidano, S., L. M. Randall, L. Dawson, H. K. Dietrich, C. Konradt, P. J. Klover, B. John, T. H. Harris, Q. Fang, B. Turek, et al., "STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.", MBio, vol. 7, issue 6, 2016 Nov 08. PubMed PMCID: PMC5101356 PMID: 27834206

2014

Cekanaviciute, E., H. K. Dietrich, R. C. Axtell, A. M. Williams, R. Egusquiza, K. M. Wai, A. A. Koshy, and M. S. Buckwalter, "Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.", J Immunol, vol. 193, issue 1, pp. 139-49, 2014 Jul 1. PubMed PMCID: PMC4075480 PMID: 24860191

Christian, D. A., A. A. Koshy, M. A. Reuter, M. R. Betts, J. C. Boothroyd, and C. A. Hunter, "Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.", Infect Immun, vol. 82, issue 10, pp. 4056-67, 2014 Oct. PubMed PMCID: PMC4187868 PMID: 25024368

Blader, I. J., and A. A. Koshy, "Toxoplasma gondii development of its replicative niche: in its host cell and beyond.", Eukaryot Cell, vol. 13, issue 8, pp. 965-76, 2014 Aug. PubMed PMCID: PMC4135789 PMID: 24951442

Han, S-J., H. J. Melichar, J. L. Coombes, S. Wei Chan, A. A. Koshy, J. C. Boothroyd, G. M. Barton, and E. A. Robey, "Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.", Immunol Cell Biol, vol. 92, issue 10, pp. 872-81, 2014 Nov. PubMed PMCID: PMC4245188 PMID: 25155465

Koshy, A. A., and C. M. Cabral, "3-D imaging and analysis of neurons infected in vivo with Toxoplasma gondii.", J Vis Exp, issue 94, 2014. PubMed PMCID: PMC4362681 PMID: 25549001

2013

Caffaro, C. E., A. A. Koshy, L. Liu, G. M. Zeiner, C. B. Hirschberg, and J. C. Boothroyd, "A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites.", PLoS Pathog, vol. 9, issue 5, pp. e1003331, 2013. PubMed PMCID: PMC3642066 PMID: 23658519

Coombes, J. L., B. A. Charsar, S-J. Han, J. Halkias, S. Wei Chan, A. A. Koshy, B. Striepen, and E. A. Robey, "Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread.", Proc Natl Acad Sci U S A, vol. 110, issue 21, pp. E1913-22, 2013 May 21. PubMed PMCID: PMC3666704 PMID: 23650399

2012

Koshy, A. A., H. K. Dietrich, D. A. Christian, J. H. Melehani, A. J. Shastri, C. A. Hunter, and J. C. Boothroyd, "Toxoplasma co-opts host cells it does not invade.", PLoS Pathog, vol. 8, issue 7, pp. e1002825, 2012. PubMed PMCID: PMC3406079 PMID: 22910631

2010

Koshy, A. A., A. E. Fouts, M. B. Lodoen, O. Alkan, H. M. Blau, and J. C. Boothroyd, "Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions.", Nat Methods, vol. 7, issue 4, pp. 307-9, 2010 Apr. PubMed PMCID: PMC2850821 PMID: 20208532