Samuel K Campos, PhD

Professor, Immunobiology

Associate Professor, Molecular and Cellular Biology

Associate Professor, Cancer Biology-GIDP

Associate Professor, BIO5 Institute

1656 E. Mabel Street
P.O. Box 245221
Tucson, AZ 85724-5221

BIO5 Institute Suite 429

(520) 626-4842

skcampos@arizona.edu

Links

Campos Lab

Bibliography Links

Sam earned his Ph.D. from Rice University in 2005, studying the biology of adenoviral gene therapy vectors and vector targeting in the laboratory of Michael Barry now at Mayo Clinic in Rochester, MN. He then trained as a postdoc from 2005-2008 with Michelle Ozbun at the University of New Mexico, focusing on human papillomavirus (HPV) infection. Sam came to The University of Arizona in 2008 as an assistant research professor in the BIO5 Institute and joined the Department of Immunobiology as an assistant professor in 2011. Sam was promoted to Associate Professor with tenure in 2017 and Full Professor in 2025.

Research Interests

Pathogenesis of human papillomavirus (HPV)

Publications

Cabel, Carly R, Guzman, Briana A, Alizadeh, Elaheh, et al. Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors. Front Cell Dev Biol. 2025;13:1538934. doi:10.3389/fcell.2025.1538934

Li, Shuaizhi, Williamson, Zachary L, Christofferson, Matthew A, Jeevanandam, Advait, Campos, Samuel K. A Peptide Derived from Sorting Nexin 1 Inhibits HPV16 Entry, Retrograde Trafficking, and L2 Membrane Spanning. Tumour Virus Res. Published online January 1, 2024:200287. doi:10.1016/j.tvr.2024.200287

Rizzato, Matteo, Mao, Fuxiang, Chardon, Florian, et al. Master mitotic kinases regulate viral genome delivery during papillomavirus cell entry. Nat Commun. 2023;14(1):355. doi:10.1038/s41467-023-35874-w

Iwanski, Jessika, Kazmouz, Sobhi G, Li, Shuaizhi, et al. Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells. Stem Cell Reports. Published online January 1, 2021. doi:10.1016/j.stemcr.2021.08.018

Chen, Elaine C, Gilchuk, Pavlo, Zost, Seth J, et al. Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals. Cell Rep. 2021;36(8):109604. doi:10.1016/j.celrep.2021.109604

Perez-Miller, Samantha, Patek, Marcel, Moutal, Aubin, et al. Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry. ACS Chem Neurosci. 2021;12(8):1299-1312. doi:10.1021/acschemneuro.0c00619

Ozbun, Michelle A, Campos, Samuel K. The long and winding road: human papillomavirus entry and subcellular trafficking. Curr Opin Virol. 2021;50:76-86. doi:10.1016/j.coviro.2021.07.010

Uhlorn, Brittany L, Gamez, Eduardo R, Li, Shuaizhi, Campos, Samuel K. Attenuation of cGAS/STING activity during mitosis. Life Sci Alliance. 2020;3(9). doi:10.26508/lsa.201900636

Uhlorn, Brittany L, Jackson, Robert, Li, Shuaizhi, Bratton, Shauna M, Van Doorslaer, Koenraad, Campos, Samuel K. Vesicular trafficking permits evasion of cGAS/STING surveillance during initial human papillomavirus infection. PLoS Pathog. 2020;16(11):e1009028. doi:10.1371/journal.ppat.1009028

Li, Shuaizhi, Bronnimann, Matthew P, Williams, Spencer J, Campos, Samuel K. Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome. PLoS One. 2019;14(11):e0225496. doi:10.1371/journal.pone.0225496

Aydin, Inci, Villalonga-Planells, Ruth, Greune, Lilo, et al. A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PLoS Pathog. 2017;13(5):e1006308. doi:10.1371/journal.ppat.1006308

Calton, Christine M, Bronnimann, Matthew P, Manson, Ariana R, et al. Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis. PLoS Pathog. 2017;13(5):e1006200. doi:10.1371/journal.ppat.1006200

Campos, Samuel K. Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2. Viruses. 2017;9(12). doi:10.3390/v9120370

Bronnimann, Matthew P, Calton, Christine M, Chiquette, Samantha F, et al. Furin Cleavage of L2 During Papillomavirus Infection: Minimal Dependence on Cyclophilins. J Virol. Published online January 1, 2016. doi:10.1128/JVI.00038-16

Campos, Samuel K. New structural model of adenoviral cement proteins is not yet concrete. Proc Natl Acad Sci U S A. 2014;111(43):E4542-3. doi:10.1073/pnas.1415364111

Calton, Christine M, Schlegel, Angela M, Chapman, Janice A, Campos, Samuel K. Human papillomavirus type 16 does not require cathepsin L or B for infection. J Gen Virol. 2013;94(Pt 8):1865-1869. doi:10.1099/vir.0.053694-0

Bronnimann, Matthew P, Chapman, Janice A, Park, Chad K, Campos, Samuel K. A transmembrane domain and GxxxG motifs within L2 are essential for papillomavirus infection. J Virol. 2013;87(1):464-73. doi:10.1128/JVI.01539-12

Campos, Samuel K, Chapman, Janice A, Deymier, Martin J, Bronnimann, Matthew P, Ozbun, Michelle A. Opposing effects of bacitracin on human papillomavirus type 16 infection: enhancement of binding and entry and inhibition of endosomal penetration. J Virol. 2012;86(8):4169-81. doi:10.1128/JVI.05493-11

Bergant Marušič, Martina, Ozbun, Michelle A, Campos, Samuel K, Myers, Michael P, Banks, Lawrence. Human papillomavirus L2 facilitates viral escape from late endosomes via sorting nexin 17. Traffic. 2012;13(3):455-67. doi:10.1111/j.1600-0854.2011.01320.x

Campos, Samuel K, Ozbun, Michelle A. Two highly conserved cysteine residues in HPV16 L2 form an intramolecular disulfide bond and are critical for infectivity in human keratinocytes. PLoS One. 2009;4(2):e4463. doi:10.1371/journal.pone.0004463