Mladen Jergovic, Ph.D.

Assistant Research Professor, Immunobiology

Portrait of a man with shoulder-length hair wearing a patterned sweater standing against a plain background with arms crossed

Medical Research Building
1656 E Mabel St
Tucson, AZ 85719
240

mjergovic@arizona.edu

Links

Bibliography Links

Mladen Jergovic obtained his masters and doctoral degrees at the University of Zagreb, Croatia. In 2015, he joined the Nikolich-Zugich lab as a postdoctoral researcher, where he is currently investigating the molecular mechanisms behind age-dependent vulnerability to infection with intracellular pathogens. Mladen is a postdoc with two small children, so he has no free time or hobbies.

Publications

Jergović, Mladen, Watanabe, Makiko, Bhat, Ruchika, et al. T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults. Geroscience. 2023;45(3):1713-1728. doi:10.1007/s11357-022-00724-y

Uhrlaub, Jennifer L, Jergović, Mladen, Bradshaw, Christine M, et al. Quantitative restoration of immune defense in old animals determined by naive antigen-specific CD8 T-cell numbers. Aging Cell. 2022;21(4):e13582. doi:10.1111/acel.13582

Jergović, Mladen, Uhrlaub, Jennifer L, Watanabe, Makiko, et al. Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination. Nat Commun. 2022;13(1):2891. doi:10.1038/s41467-022-30617-9

Jergović, Mladen, Coplen, Christopher P, Uhrlaub, Jennifer L, et al. Cutting Edge: T Cell Responses to B.1.1.529 (Omicron) SARS-CoV-2 Variant Induced by COVID-19 Infection and/or mRNA Vaccination Are Largely Preserved. J Immunol. 2022;208(11):2461-2465. doi:10.4049/jimmunol.2200175

Sonar, Sandip Ashok, Uhrlaub, Jennifer L, Coplen, Christopher P, et al. Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging. Proc Natl Acad Sci U S A. 2022;119(17):e2121028119. doi:10.1073/pnas.2121028119

Shroff, Rachna T, Chalasani, Pavani, Wei, Ran, et al. Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors. Nat Med. 2021;27(11):2002-2011. doi:10.1038/s41591-021-01542-z

Jergović, Mladen, Uhrlaub, Jennifer L, Contreras, Nico A, Nikolich-Zugich, Janko. Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues? Geroscience. 2019;41(2):155-163. doi:10.1007/s11357-019-00068-0

Thompson, Heather L, Smithey, Megan J, Uhrlaub, Jennifer L, et al. Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates. Aging Cell. 2019;18(1):e12865. doi:10.1111/acel.12865

Jergović, Mladen, Thompson, Heather L, Renkema, Kristin R, Smithey, Megan J, Nikolich-Zugich, Janko. Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18. Front Immunol. 2019;10:2206. doi:10.3389/fimmu.2019.02206

Jergović, Mladen, Contreras, Nico A, Nikolich-Zugich, Janko. Impact of CMV upon immune aging: facts and fiction. Med Microbiol Immunol. Published online January 1, 2019. doi:10.1007/s00430-019-00605-w

Savić Mlakar, Ana, Hojsak, Iva, Jergović, Mladen, Čimić, Samir, Bendelja, Krešo. Pediatric Crohn disease is characterized by Th1 in the terminal ileum and Th1/Th17 immune response in the colon. Eur J Pediatr. 2018;177(4):611-616. doi:10.1007/s00431-017-3076-8

Jergović, Mladen, Smithey, Megan J, Nikolich-Zugich, Janko. Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging. Exp Gerontol. 2018;105:140-145. doi:10.1016/j.exger.2018.01.011

Savić Mlakar, Ana, Hojsak, Iva, Jergović, Mladen, et al. Comparison of Cytokine and Efflux Transporter Expression in Pediatric Versus Adult-onset Ulcerative Colitis. J Pediatr Gastroenterol Nutr. 2017;64(6):943-948. doi:10.1097/MPG.0000000000001403

Jagušić, Maja, Forčić, Dubravko, Brgles, Marija, et al. Stability of Minimum Essential Medium functionality despite L-glutamine decomposition. Cytotechnology. 2016;68(4):1171-83. doi:10.1007/s10616-015-9875-8

Jergović, Mladen, Bendelja, Krešo, Savić Mlakar, Ana, et al. Circulating levels of hormones, lipids, and immune mediators in post-traumatic stress disorder - a 3-month follow-up study. Front Psychiatry. 2015;6:49. doi:10.3389/fpsyt.2015.00049

Jergović, Mladen, Bendelja, Krešo, Vidović, Anđelko, et al. Patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells. Allergy Asthma Clin Immunol. 2014;10(1):43. doi:10.1186/1710-1492-10-43