Mark S Lee

Research Specialist

Portrait of a smiling man wearing a dark shirt indoors with a museum exhibit in the background

1656 E Mabel St
Tucson, AZ 85724

Medical Research Building
Room 240

Mark received his Bachelor's degree from the University of Arizona in 2011. He subsequently joined the lab to investigate the mechanics of TCR triggering. Mark likes to run Half-Marathons and excels in baking delicious cakes.

Publications

Lee, Mark S, Tuohy, Peter J, Kim, Caleb Y, et al. The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions. Elife. 2024;12. doi:10.7554/eLife.88225

Lee, Mark S, Tuohy, Peter J, Kim, Caleb Y, et al. Enhancing and inhibitory motifs regulate CD4 activity. Elife. 2022;11. doi:10.7554/eLife.79508

Kobayashi, Shio, Thelin, Martin A, Parrish, Heather L, et al. A biomimetic five-module chimeric antigen receptor (CAR) designed to target and eliminate antigen-specific T cells. Proc Natl Acad Sci U S A. 2020;117(46):28950-28959. doi:10.1073/pnas.2012495117

Lichauco, Katrina, Lee, Mark S, Kuhns, Michael S. Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed. Immunity. 2018;49(5):786-788. doi:10.1016/j.immuni.2018.11.008

Glassman, Caleb R, Parrish, Heather L, Lee, Mark S, Kuhns, Michael S. Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep. 2018;22(5):1263-1275. doi:10.1016/j.celrep.2017.12.104

Bethune, Michael T, Gee, Marvin H, Bunse, Mario, et al. Domain-swapped T cell receptors improve the safety of TCR gene therapy. Elife. 2016;5. doi:10.7554/eLife.19095

Lee, Mark S, Glassman, Caleb R, Deshpande, Neha R, et al. A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ. Immunity. 2015;43(2):227-39. doi:10.1016/j.immuni.2015.06.018

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Mark S Lee

Publications