Jennifer Frye

Assistant Scientific Investigator

Portrait of a smiling woman with long blonde hair wearing a red top and a necklace, standing in front of a brick wall

Building Address:
1656 E Mabel St
Tucson, AZ 85724
Room 230

Location:
Medical Research Building
Room 240

Jen Frye received her Bachelor’s Degree in Ecology and Evolutionary Biology from The University of Arizona. In the Doyle lab, Jen employs her extensive research background to investigate the inflammatory response to stroke in humans as well as different rodent models. In her spare time, Jen enjoys football, wakeboarding, and spending time with her family.

Publications

Becktel, Danielle A, Le, Elizabeth H, Frye, Jennifer B, Whitman, Susan A, Schnellmann, Rick G, Doyle, Kristian P. 2-Hydroxypropyl-β-cyclodextrin accesses acute and subacute infarcts in a mouse model of ischemic stroke. Fluids Barriers CNS. Published online January 1, 2026. doi:10.1186/s12987-026-00767-9

Peterson, Ingrid L, Scholpa, Natalie E, Bachtle, Kiara J, et al. Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice. J Pharmacol Exp Ther. 2025;392(2):100015. doi:10.1124/jpet.124.002171

Brezzo, Gaia, Zera, Kristy A, Straus, Dana E, et al. Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study. J Cereb Blood Flow Metab. Published online January 1, 2025:271678X251400241. doi:10.1177/0271678X251400241

Arizanovska, Dena, Bush Iii, Gerald F, Dallera, Carlos A, et al. Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes. Brain. Published online January 1, 2025. doi:10.1093/brain/awaf293

Becktel, Danielle A, Frye, Jennifer B, Le, Elizabeth H, Schnellmann, Rick G, Doyle, Kristian P. Plasma Biomarker Profiling of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Treatment in an Aged Mouse Model of Ischemic Stroke. Int J Mol Sci. 2025;26(22). doi:10.3390/ijms262210814

Becktel, Danielle A, Frye, Jennifer B, Le, Elizabeth H, et al. Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model. J Lipid Res. 2024;65(9):100614. doi:10.1016/j.jlr.2024.100614

Arizanovska, Dena, Dallera, Carlos A, Folorunso, Oluwarotimi O, et al. Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes. bioRxiv. Published online January 1, 2024. doi:10.1101/2024.08.13.607610

Pederson, William P, Ellerman, Laurie M, Sandoval, Estevan C, et al. Development of a Novel Mouse Model of Menopause-associated Asthma. Am J Respir Cell Mol Biol. 2022;67(5):605-609. doi:10.1165/rcmb.2022-0181LE

Nguyen, Thuy-Vi V, Hayes, Megan, Zbesko, Jacob C, et al. Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. Acta Neuropathol Commun. 2018;6(1):100. doi:10.1186/s40478-018-0603-4

Chung, Amanda G, Frye, Jennifer B, Zbesko, Jacob C, et al. Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism. eNeuro. 2018;5(5). doi:10.1523/ENEURO.0076-18.2018

Nguyen, Thuy-Vi V, Frye, Jennifer B, Zbesko, Jacob C, et al. Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue. Acta Neuropathol Commun. 2016;4(1):100. doi:10.1186/s40478-016-0371-y

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Jennifer Frye

Publications