Publications
Lee, Mark S, Tuohy, Peter J, Kim, Caleb Y, et al. The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions. Elife. 2024;12. doi:10.7554/eLife.88225
Lee, Mark S, Tuohy, Peter J, Kim, Caleb Y, et al. Enhancing and inhibitory motifs regulate CD4 activity. Elife. 2022;11. doi:10.7554/eLife.79508
Kim, Caleb Y, Parrish, Heather L, Kuhns, Michael S. The TCR Cα Domain Regulates Responses to Self-pMHC Class II. J Immunol. 2022;209(10):2033-2041. doi:10.4049/jimmunol.2200377
Kobayashi, Shio, Thelin, Martin A, Parrish, Heather L, et al. A biomimetic five-module chimeric antigen receptor (CAR) designed to target and eliminate antigen-specific T cells. Proc Natl Acad Sci U S A. 2020;117(46):28950-28959. doi:10.1073/pnas.2012495117
Glassman, Caleb R, Parrish, Heather L, Lee, Mark S, Kuhns, Michael S. Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep. 2018;22(5):1263-1275. doi:10.1016/j.celrep.2017.12.104
Parrish, Heather L, Glassman, Caleb R, Keenen, Madeline M, Deshpande, Neha R, Bronnimann, Matthew P, Kuhns, Michael S. Correction: A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS One. 2016;11(3):e0150876. doi:10.1371/journal.pone.0150876
Parrish, Heather L, Deshpande, Neha R, Vasic, Jelena, Kuhns, Michael S. Functional evidence for TCR-intrinsic specificity for MHCII. Proc Natl Acad Sci U S A. Published online January 1, 2016. doi:10.1073/pnas.1518499113
Glassman, Caleb R, Parrish, Heather L, Deshpande, Neha R, Kuhns, Michael S. The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex. J Immunol. 2016;196(11):4713-22. doi:10.4049/jimmunol.1502110
Lee, Mark S, Glassman, Caleb R, Deshpande, Neha R, et al. A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ. Immunity. 2015;43(2):227-39. doi:10.1016/j.immuni.2015.06.018
Parrish, Heather L, Glassman, Caleb R, Keenen, Madeline M, Deshpande, Neha R, Bronnimann, Matthew P, Kuhns, Michael S. A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS One. 2015;10(7):e0132333. doi:10.1371/journal.pone.0132333