Felicia Goodrum, PhD

Interim Associate Department Head, Immunobiology

Member of the Graduate Faculty

Professor, BIO5 Institute

Professor, Cancer Biology - GIDP

Professor, Cellular and Molecular Medicine

Professor, Genetics - GIDP

Professor, Immunobiology

Professor, Molecular and Cellular Biology

BIO5 Institute
Suite 425

1656 E. Mabel Street
P.O. Box 245221
Tucson, AZ 85724-5221

(520) 626-7468

fgoodrum@arizona.edu

Links

Goodrum Lab

Bibliography Link

Felicia Goodrum graduated with her Ph.D. from Wake Forest University and then trained as a postdoctoral fellow with Thomas Shenk at Princeton University where she was a Leukemia and Lymphoma Society Fellow and Special Fellow. In 2006, Dr. Goodrum joined the faculty at the University of Arizona and BIO5 Institute. Dr. Goodrum is the recipient of the Howard Temin Award, the Pew Scholar in Biomedical Sciences Award and the Presidential Award for Early Career Scientists and Engineers. Dr. Goodrum’s work throughout her career has focused on complex interaction between DNA viruses and their host.

Leadership Roles Faculty Student Advisor, Immunobiology Recipient, Presidential Early Career Award for Scientists and Engineers Leader, research lab Active Participant, building the Immunobiology graduate program

Degrees

BS: Virgina Tech - 1992
PhD: Wake Forest University School of Medicine - 1998

Work Experience

Postdoctoral fellow: Princeton University, Department of Molecular Biology

Publications

Kline, Ian, Mokry, Rebekah L, Xi, Yuecheng, et al. Human cytomegalovirus promotes PC synthesis during early virus replication. J Virol. 2025;99(9):e0057925. doi:10.1128/jvi.00579-25

White, Timothy M, Goodrum, Felicia D. Viruses trick bystander cells into lowering their defences. Nature. 2023;619(7968):39-40. doi:10.1038/d41586-023-02135-1

Alwine, James C, Casadevall, Arturo, Enquist, Lynn W, Goodrum, Felicia D, Imperiale, Michael J. A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses. mSphere. 2023;8(2):e0011923. doi:10.1128/msphere.00119-23

Runstadler, Jonathan A, Lowen, Anice C, Kayali, Ghazi, et al. Field Research Is Essential to Counter Virological Threats. J Virol. 2023;97(5):e0054423. doi:10.1128/jvi.00544-23

Lowen, Anice C, Casadevall, Arturo, Alwine, James C, et al. Oversight of Pathogen Research Must Be Carefully Calibrated and Clearly Defined. J Virol. 2023;97(3):e0017623. doi:10.1128/jvi.00176-23

Imperiale, Michael J, Casadevall, Arturo, Goodrum, Felicia D, Schultz-Cherry, Stacey. Virology in Peril and the Greater Risk To Science. J Virol. 2023;97(1):e0184722. doi:10.1128/jvi.01847-22

Zhang, Hongbo, Domma, Anthony J, Goodrum, Felicia D, Moorman, Nathaniel J, Kamil, Jeremy P. The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication. mBio. 2022;13(4):e0104222. doi:10.1128/mbio.01042-22

Crawford, Lindsey B, Tempel, Rebecca, Streblow, Daniel N, et al. Human Cytomegalovirus Infection Suppresses CD34 Progenitor Cell Engraftment in Humanized Mice. Microorganisms. 2020;8(4). doi:10.3390/microorganisms8040525

Hancock, Meaghan H, Mitchell, Jennifer, Goodrum, Felicia D, Nelson, Jay A. Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways. mSphere. 2020;5(4). doi:10.1128/mSphere.00582-20

Mlera, Luwanika, Moy, Melissa, Maness, Kristen, Tran, Linh N, Goodrum, Felicia D. The Role of the Human Cytomegalovirus Gene Locus in Latency and Reactivation. Viruses. 2020;12(7). doi:10.3390/v12070714

Collins-McMillen, Donna, Goodrum, Felicia D. The loss of binary: Pushing the herpesvirus latency paradigm. Curr Clin Microbiol Rep. 2017;4(3):124-131. doi:10.1007/s40588-017-0072-8

Kim, Jung Heon, Collins-McMillen, Donna, Buehler, Jason C, Goodrum, Felicia D, Yurochko, Andrew D. Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells. J Virol. 2017;91(5). doi:10.1128/JVI.01206-16

Leng, Sean X, Kamil, Jeremy, Purdy, John G, Lemmermann, Niels A, Reddehase, Matthias J, Goodrum, Felicia D. Recent advances in CMV tropism, latency, and diagnosis during aging. Geroscience. 2017;39(3):251-259. doi:10.1007/s11357-017-9985-7

Li, Gang, Rak, Michael, Nguyen, Christopher C, Umashankar, Mahadevaiah, Goodrum, Felicia D, Kamil, Jeremy P. An epistatic relationship between the viral protein kinase UL97 and the UL133-UL138 latency locus during the human cytomegalovirus lytic cycle. J Virol. 2014;88(11):6047-60. doi:10.1128/JVI.00447-14

Umashankar, Mahadevaiah, Rak, Michael, Bughio, Farah, Zagallo, Patricia, Caviness, Katie, Goodrum, Felicia D. Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection. J Virol. 2014;88(11):5987-6002. doi:10.1128/JVI.03506-13

Goodrum, Felicia D, Jordan, Craig T, High, Kevin, Shenk, Thomas. Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: a model for latency. Proc Natl Acad Sci U S A. 2002;99(25):16255-60. doi:10.1073/pnas.252630899

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Felicia Goodrum, PhD

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