Reference
Kuhns, Michael S, Davis, Mark M. The safety on the TCR trigger. Cell. 2008;135(4):594-6. doi:10.1016/j.cell.2008.10.033
Abstract
In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate with the plasma membrane such that the key signaling tyrosines are sequestered in the bilayer.