Reference
Wu, Hsin-Jung Joyce. Methotrexate works remotely, from the gut. Cell Host Microbe. 2021;29(3):325-326. doi:10.1016/j.chom.2021.02.016
Abstract
In this COVID era, when many struggle to work remotely, methotrexate (MTX) has been doing so all along. In this issue of Cell Host & Microbe, Nayak et al. discover that MTX reduces immune activation due to off-target effects on the gut microbiota, potentially explaining MTX's anti-inflammatory effects.