Reference
Centuori, Sara M, Bhattacharya, Deepta. Locally produced autoantibodies in cancer. Cell. 2022;185(7):1110-1111. doi:10.1016/j.cell.2022.03.006
Abstract
The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).