Reference
Lesterhuis, W Joost, Bosco, Anthony, Lake, Richard A. Comment on "drug discovery: turning the titanic". Sci Transl Med. 2014;6(229):229le2. doi:10.1126/scitranslmed.3008763
Abstract
The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.