Reference
Lichauco, Katrina, Lee, Mark S, Kuhns, Michael S. Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed. Immunity. 2018;49(5):786-788. doi:10.1016/j.immuni.2018.11.008
Abstract
How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.