Publications

2020

Crawford, L. B., R. Tempel, D. N. Streblow, A. D. Yurochko, F. D. Goodrum, J. A. Nelson, and P. Caposio, "Human Cytomegalovirus Infection Suppresses CD34 Progenitor Cell Engraftment in Humanized Mice.", Microorganisms, vol. 8, issue 4, 2020 Apr 06. PMCID: PMC7232458  PMID: 32268565
Rak, M. A., J. Buehler, S. Zeltzer, J. Reitsma, B. Molina, S. Terhune, and F. Goodrum, "Erratum for Rak et al., "Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency".", J Virol, vol. 94, issue 7, 2020 03 17. PMCID: PMC7081901  PMID: 32184335
Hancock, M. H., J. Mitchell, F. D. Goodrum, and J. A. Nelson, "Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways.", mSphere, vol. 5, issue 4, 2020 Aug 05. PMCID: PMC7407068  PMID: 32759334
Hale, A. E., D. Collins-McMillen, E. M. Lenarcic, S. Igarashi, J. P. Kamil, F. Goodrum, and N. J. Moorman, "FOXO transcription factors activate alternative major immediate early promoters to induce human cytomegalovirus reactivation.", Proc Natl Acad Sci U S A, vol. 117, issue 31, pp. 18764-18770, 2020 08 04. PMCID: PMC7414233  PMID: 32694203
Mlera, L., M. Moy, K. Maness, L. N. Tran, and F. D. Goodrum, "The Role of the Human Cytomegalovirus Gene Locus in Latency and Reactivation.", Viruses, vol. 12, issue 7, 2020 07 01. PMCID: PMC7411667  PMID: 32630219
Chaturvedi, S., J. Klein, N. Vardi, C. Bolovan-Fritts, M. Wolf, K. Du, L. Mlera, M. Calvert, N. J. Moorman, F. Goodrum, et al., "A molecular mechanism for probabilistic bet hedging and its role in viral latency.", Proc Natl Acad Sci U S A, vol. 117, issue 29, pp. 17240-17248, 2020 07 21. PMCID: PMC7382263  PMID: 32632017

2019

Buehler, J., E. Carpenter, S. Zeltzer, S. Igarashi, M. Rak, I. Mikell, J. A. Nelson, and F. Goodrum, "Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency.", PLoS Pathog, vol. 15, issue 11, pp. e1008037, 2019 11. PMCID: PMC6855412  PMID: 31725811
Mikell, I., L. B. Crawford, M. H. Hancock, J. Mitchell, J. Buehler, F. Goodrum, and J. A. Nelson, "HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation.", PLoS Pathog, vol. 15, issue 11, pp. e1007854, 2019 11. PMCID: PMC6855405  PMID: 31725809

2018

Collins-McMillen, D., J. Buehler, M. Peppenelli, and F. Goodrum, "Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation.", Viruses, vol. 10, issue 8, 2018 08 20. PMCID: PMC6116278  PMID: 30127257
Rak, M. A., J. Buehler, S. Zeltzer, J. Reitsma, B. Molina, S. Terhune, and F. Goodrum, "Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.", J Virol, vol. 92, issue 20, 2018 10 15. PMCID: PMC6158428  PMID: 30089695
Zeltzer, S., C. A. Zeltzer, S. Igarashi, J. Wilson, J. G. Donaldson, and F. Goodrum, "Virus Control of Trafficking from Sorting Endosomes.", MBio, vol. 9, issue 4, 2018 07 24. PMCID: PMC6058287  PMID: 30042195
Goodrum, F., and S. McWeeney, "A Single-Cell Approach to the Elusive Latent Human Cytomegalovirus Transcriptome.", MBio, vol. 9, issue 3, 2018 06 12. PMCID: PMC6016237  PMID: 29895640

2017

Cheng, S., K. Caviness, J. Buehler, M. Smithey, J. Nikolich-Zugich, and F. Goodrum, "Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency.", Proc Natl Acad Sci U S A, vol. 114, issue 49, pp. E10586-E10595, 2017 Dec 05. PMCID: PMC5724264  PMID: 29158406
Collins-McMillen, D., and F. D. Goodrum, "The loss of binary: Pushing the herpesvirus latency paradigm.", Curr Clin Microbiol Rep, vol. 4, issue 3, pp. 124-131, 2017 Sep. PMCID: PMC5726573  PMID: 29250481
Kim, J. Heon, D. Collins-McMillen, J. C. Buehler, F. D. Goodrum, and A. D. Yurochko, "Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells.", J Virol, vol. 91, issue 5, 2017 Mar 01. PMCID: PMC5309964  PMID: 27974567
Gordon, C. L., M. Miron, J. J. C. Thome, N. Matsuoka, J. Weiner, M. A. Rak, S. Igarashi, T. Granot, H. Lerner, F. Goodrum, et al., "Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection.", J Exp Med, vol. 214, issue 3, pp. 651-667, 2017 Mar 06. PMCID: PMC5339671  PMID: 28130404

2016

Caviness, K., F. Bughio, L. B. Crawford, D. N. Streblow, J. A. Nelson, P. Caposio, and F. Goodrum, "Complex Interplay of the UL136 Isoforms Balances Cytomegalovirus Replication and Latency.", MBio, vol. 7, issue 2, pp. e01986, 2016 Mar 01. PMCID: PMC4810493  PMID: 26933055
Lee, S. Hee, K. Caviness, E. R. Albright, J-H. Lee, C. B. Gelbmann, M. Rak, F. Goodrum, and R. F. Kalejta, "Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency.", J Virol, vol. 90, issue 20, pp. 9483-94, 2016 10 15. PMCID: PMC5044833  PMID: 27512069

2015

Bughio, F., M. Umashankar, J. Wilson, and F. Goodrum, "Human Cytomegalovirus UL135 and UL136 Genes Are Required for Postentry Tropism in Endothelial Cells.", J Virol, vol. 89, issue 13, pp. 6536-50, 2015 Jul. PMCID: PMC4468499  PMID: 25878111
Goodrum, F., and F. Bughio, "Viral infection at the endothelium.", Oncotarget, vol. 6, issue 29, pp. 26541-2, 2015 Sep 29. PMCID: PMC4694926  PMID: 26309089

2014

Li, G., M. Rak, C. C. Nguyen, M. Umashankar, F. D. Goodrum, and J. P. Kamil, "An epistatic relationship between the viral protein kinase UL97 and the UL133-UL138 latency locus during the human cytomegalovirus lytic cycle.", J Virol, vol. 88, issue 11, pp. 6047-60, 2014 Jun. PMCID: PMC4093856  PMID: 24623439
Caviness, K., L. Cicchini, M. Rak, M. Umashankar, and F. Goodrum, "Complex expression of the UL136 gene of human cytomegalovirus results in multiple protein isoforms with unique roles in replication.", J Virol, vol. 88, issue 24, pp. 14412-25, 2014 Dec. PMCID: PMC4249117  PMID: 25297993
Umashankar, M., and F. Goodrum, "Hematopoietic long-term culture (hLTC) for human cytomegalovirus latency and reactivation.", Methods Mol Biol, vol. 1119, pp. 99-112, 2014. PMID: 24639220
Umashankar, M., M. Rak, F. Bughio, P. Zagallo, K. Caviness, and F. D. Goodrum, "Antagonistic determinants controlling replicative and latent states of human cytomegalovirus infection.", J Virol, vol. 88, issue 11, pp. 5987-6002, 2014 Jun. PMCID: PMC4093889  PMID: 24623432

2013

Bughio, F., D. A. Elliott, and F. Goodrum, "An endothelial cell-specific requirement for the UL133-UL138 locus of human cytomegalovirus for efficient virus maturation.", J Virol, vol. 87, issue 6, pp. 3062-75, 2013 Mar. PMCID: PMC3592143  PMID: 23283945

2012

Petrucelli, A., M. Umashankar, P. Zagallo, M. Rak, and F. Goodrum, "Interactions between proteins encoded within the human cytomegalovirus UL133-UL138 locus.", J Virol, vol. 86, issue 16, pp. 8653-62, 2012 Aug. PMCID: PMC3421763  PMID: 22674978
Goodrum, F., K. Caviness, and P. Zagallo, "Human cytomegalovirus persistence.", Cell Microbiol, vol. 14, issue 5, pp. 644-55, 2012 May. PMCID: PMC3330195  PMID: 22329758

2011

Umashankar, M., A. Petrucelli, L. Cicchini, P. Caposio, C. N. Kreklywich, M. Rak, F. Bughio, D. C. Goldman, K. L. Hamlin, J. A. Nelson, et al., "A novel human cytomegalovirus locus modulates cell type-specific outcomes of infection.", PLoS Pathog, vol. 7, issue 12, pp. e1002444, 2011 Dec. PMCID: PMC3248471  PMID: 22241980

2010

Grainger, L., L. Cicchini, M. Rak, A. Petrucelli, K. D. Fitzgerald, B. L. Semler, and F. Goodrum, "Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138.", J Virol, vol. 84, issue 18, pp. 9472-86, 2010 Sep. PMCID: PMC2937619  PMID: 20592073
Tey, S-K., F. Goodrum, and R. Khanna, iv, "CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138.", J Gen Virol, vol. 91, issue Pt 8, pp. 2040-8, 2010 Aug. PMCID: PMC4091183  PMID: 20375220

2009

Petrucelli, A., M. Rak, L. Grainger, and F. Goodrum, "Characterization of a novel Golgi apparatus-localized latency determinant encoded by human cytomegalovirus.", J Virol, vol. 83, issue 11, pp. 5615-29, 2009 Jun. PMCID: PMC2681962  PMID: 19297488

2007

Goodrum, F., M. Reeves, J. Sinclair, K. High, and T. Shenk, "Human cytomegalovirus sequences expressed in latently infected individuals promote a latent infection in vitro.", Blood, vol. 110, issue 3, pp. 937-45, 2007 Aug 1. PMCID: PMC1924770  PMID: 17440050

2004

Goodrum, F., C. T. Jordan, S. S. Terhune, K. High, and T. Shenk, "Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations.", Blood, vol. 104, issue 3, pp. 687-95, 2004 Aug 1. PMID: 15090458

2002

Goodrum, F. D., C. T. Jordan, K. High, and T. Shenk, "Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: a model for latency.", Proc Natl Acad Sci U S A, vol. 99, issue 25, pp. 16255-60, 2002 Dec 10. PMCID: PMC138598  PMID: 12456880

1999

Goodrum, F. D., and D. A. Ornelles, "Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.", J Virol, vol. 73, issue 9, pp. 7474-88, 1999 Sep. PMCID: PMC104274  PMID: 10438837

1997

Goodrum, F. D., and D. A. Ornelles, "The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle.", J Virol, vol. 71, issue 1, pp. 548-61, 1997 Jan. PMCID: PMC191084  PMID: 8985383

1996

Goodrum, F. D., T. Shenk, and D. A. Ornelles, "Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.", J Virol, vol. 70, issue 9, pp. 6323-35, 1996 Sep. PMCID: PMC190658  PMID: 8709260