Publications
2016
Chaudhuri, L., R. K. Srivastava, F. Kos, and P. A. Shrikant, "Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells.", Cancer Immunol Immunother, vol. 65, issue 7, pp. 869-74, 2016 07.
PMCID: PMC4919150 PMID: 27271549
2015
Huang, R-Y., C. Eppolito, S. Lele, P. Shrikant, J. Matsuzaki, and K. Odunsi, "LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model.", Oncotarget, vol. 6, issue 29, pp. 27359-77, 2015 Sep 29.
PMCID: PMC4694995 PMID: 26318293
Matsuzaki, J., T. Tsuji, I. F. Luescher, H. Shiku, J. Mineno, S. Okamoto, L. J. Old, P. Shrikant, S. Gnjatic, and K. Odunsi, "Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.", Sci Rep, vol. 5, pp. 14896, 2015 Oct 08.
PMCID: PMC4597193 PMID: 26447332
Fu, C., X. Liang, W. Cui, J. L. Ober-Blöbaum, J. Vazzana, P. A. Shrikant, K. P. Lee, B. E. Clausen, I. Mellman, and A. Jiang, "β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10.", Proc Natl Acad Sci U S A, vol. 112, issue 9, pp. 2823-8, 2015 Mar 03.
PMCID: PMC4352820 PMID: 25730849
2014
Liang, X., C. Fu, W. Cui, J. L. Ober-Blöbaum, S. P. Zahner, P. A. Shrikant, B. E. Clausen, R. A. Flavell, I. Mellman, and A. Jiang, "β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells.", J Leukoc Biol, vol. 95, issue 1, pp. 179-90, 2014 Jan.
PMID: 24023259
2013
Mukhopadhyay, A., T. Khoury, L. Stein, P. Shrikant, and A. K. Sood, "Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer.", Oncotarget, vol. 4, issue 4, pp. 610-21, 2013 Apr.
PMCID: PMC3720608 PMID: 23592399
Huntoon, K. M., L. Russell, E. Tracy, K. W. Barbour, Q. Li, P. A. Shrikant, F. G. Berger, L. Ann Garrett-Sinha, and H. Baumann, "A unique form of haptoglobin produced by murine hematopoietic cells supports B-cell survival, differentiation and immune response.", Mol Immunol, vol. 55, issue 3-4, pp. 345-54, 2013 Oct.
PMCID: PMC3646973 PMID: 23548836
2012
Qian, F., J. Liao, J. Villella, R. Edwards, P. Kalinski, S. Lele, P. Shrikant, and K. Odunsi, "Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation.", Cancer Immunol Immunother, vol. 61, issue 11, pp. 2013-20, 2012 Nov.
PMID: 22527253
Srivastava, R. K., A. Utley, and P. A. Shrikant, "Rapamycin: A rheostat for CD8(+) T-cell-mediated tumor therapy.", Oncoimmunology, vol. 1, issue 7, pp. 1189-1190, 2012 Oct 01.
PMCID: PMC3494641 PMID: 23170275
Shen, L., M. Ciesielski, S. Ramakrishnan, K. M. Miles, L. Ellis, P. Sotomayor, P. Shrikant, R. Fenstermaker, and R. Pili, "Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models.", PLoS One, vol. 7, issue 1, pp. e30815, 2012.
PMCID: PMC3267747 PMID: 22303460
Li, Q., R. Rao, J. Vazzana, P. Goedegebuure, K. Odunsi, W. Gillanders, and P. A. Shrikant, "Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity.", J Immunol, vol. 188, issue 7, pp. 3080-7, 2012 Apr 01.
PMCID: PMC3311730 PMID: 22379028
Rao, R. R., Q. Li, M. R. Gubbels Bupp, and P. A. Shrikant, "Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation.", Immunity, vol. 36, issue 3, pp. 374-87, 2012 Mar 23.
PMCID: PMC3314246 PMID: 22425248
Odunsi, K., J. Matsuzaki, J. Karbach, A. Neumann, P. Mhawech-Fauceglia, A. Miller, A. Beck, C. D. Morrison, G. Ritter, H. Godoy, et al., "Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients.", Proc Natl Acad Sci U S A, vol. 109, issue 15, pp. 5797-802, 2012 Apr 10.
PMCID: PMC3326498 PMID: 22454499
2011
Li, Q., R. R. Rao, K. Araki, K. Pollizzi, K. Odunsi, J. D. Powell, and P. A. Shrikant, "A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity.", Immunity, vol. 34, issue 4, pp. 541-53, 2011 Apr 22.
PMCID: PMC3083826 PMID: 21511183
Wang, Y., X-Y. Wang, J. R. Subjeck, P. A. Shrikant, and H. L. Kim, "Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines.", Br J Cancer, vol. 104, issue 4, pp. 643-52, 2011 Feb 15.
PMCID: PMC3049595 PMID: 21285988
2010
Rao, R. R., Q. Li, K. Odunsi, and P. A. Shrikant, "The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.", Immunity, vol. 32, issue 1, pp. 67-78, 2010 Jan 29.
PMCID: PMC5836496 PMID: 20060330
Shrikant, P., and K. Lee, "Introduction to immunology at Roswell Park Cancer Institute.", Immunol Res, vol. 46, issue 1-3, pp. 1-3, 2010 Mar.
PMID: 19830394
Shrikant, P. A., R. Rao, Q. Li, J. Kesterson, C. Eppolito, A. Mischo, and P. Singhal, "Regulating functional cell fates in CD8 T cells.", Immunol Res, vol. 46, issue 1-3, pp. 12-22, 2010 Mar.
PMCID: PMC5049497 PMID: 19859830
Matsuzaki, J., S. Gnjatic, P. Mhawech-Fauceglia, A. Beck, A. Miller, T. Tsuji, C. Eppolito, F. Qian, S. Lele, P. Shrikant, et al., "Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.", Proc Natl Acad Sci U S A, vol. 107, issue 17, pp. 7875-80, 2010 Apr 27.
PMCID: PMC2867907 PMID: 20385810
Rao, R. R., Q. Li, and P. A. Shrikant, "Fine-tuning CD8(+) T cell functional responses: mTOR acts as a rheostat for regulating CD8(+) T cell proliferation, survival and differentiation?", Cell Cycle, vol. 9, issue 15, pp. 2996-3001, 2010 Aug 01.
PMID: 20699660
Li, Q., C. Eppolito, K. Odunsi, and P. A. Shrikant, "Antigen-induced Erk1/2 activation regulates Ets-1-mediated sensitization of CD8+ T cells for IL-12 responses.", J Leukoc Biol, vol. 87, issue 2, pp. 257-63, 2010 Feb.
PMCID: PMC2812555 PMID: 19843578
2009
Qian, F., J. Villella, P. K. Wallace, P. Mhawech-Fauceglia, J. D. Tario, C. Andrews, J. Matsuzaki, D. Valmori, M. Ayyoub, P. J. Frederick, et al., "Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer.", Cancer Res, vol. 69, issue 13, pp. 5498-504, 2009 Jul 01.
PMID: 19491279
2008
Tosello, V., K. Odunsi, N. E. Souleimanian, S. Lele, P. Shrikant, L. J. Old, D. Valmori, and M. Ayyoub, "Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs.", Clin Immunol, vol. 126, issue 3, pp. 291-302, 2008 Mar.
PMID: 18166500
Matsuzaki, J., F. Qian, I. Luescher, S. Lele, G. Ritter, P. A. Shrikant, S. Gnjatic, L. J. Old, and K. Odunsi, "Recognition of naturally processed and ovarian cancer reactive CD8+ T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1.", Cancer Immunol Immunother, vol. 57, issue 8, pp. 1185-95, 2008 Aug.
PMID: 18253733
Huntoon, K. M., Y. Wang, C. A. Eppolito, K. W. Barbour, F. G. Berger, P. A. Shrikant, and H. Baumann, "The acute phase protein haptoglobin regulates host immunity.", J Leukoc Biol, vol. 84, issue 1, pp. 170-81, 2008 Jul.
PMCID: PMC3178501 PMID: 18436583
Castermans, K., S. P. Tabruyn, R. Zeng, J. R. van Beijnum, C. Eppolito, W. J. Leonard, P. A. Shrikant, and A. W. Griffioen, "Angiostatic activity of the antitumor cytokine interleukin-21.", Blood, vol. 112, issue 13, pp. 4940-7, 2008 Dec 15.
PMID: 18515660
2007
Mischo, A., C. Eppolito, Q. Li, and P. A. Shrikant, "Characterizing host immune responses by monitoring fluorescently marked cells.", Immunol Invest, vol. 36, issue 5-6, pp. 791-805, 2007.
PMID: 18161529
Odunsi, K., F. Qian, J. Matsuzaki, P. Mhawech-Fauceglia, C. Andrews, E. W. Hoffman, L. Pan, G. Ritter, J. Villella, B. Thomas, et al., "Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer.", Proc Natl Acad Sci U S A, vol. 104, issue 31, pp. 12837-42, 2007 Jul 31.
PMCID: PMC1937553 PMID: 17652518
Adotevi, O., B. Vingert, L. Freyburger, P. Shrikant, Y-C. Lone, F. Quintin-Colonna, N. Haicheur, M. Amessou, A. Herbelin, P. Langlade-Demoyen, et al., "B subunit of Shiga toxin-based vaccines synergize with alpha-galactosylceramide to break tolerance against self antigen and elicit antiviral immunity.", J Immunol, vol. 179, issue 5, pp. 3371-9, 2007 Sep 01.
PMID: 17709554
2006
Li, Q., C. Eppolito, K. Odunsi, and P. A. Shrikant, "IL-12-programmed long-term CD8+ T cell responses require STAT4.", J Immunol, vol. 177, issue 11, pp. 7618-25, 2006 Dec 01.
PMID: 17114431
Hylander, B., E. Repasky, P. Shrikant, M. Intengan, A. Beck, D. Driscoll, P. Singhal, S. Lele, and K. Odunsi, "Expression of Wilms tumor gene (WT1) in epithelial ovarian cancer.", Gynecol Oncol, vol. 101, issue 1, pp. 12-7, 2006 Apr.
PMID: 16263157
Peng, L., E. Ko, W. Luo, X. Wang, P. A. Shrikant, and S. Ferrone, "CD4-dependent potentiation of a high molecular weight-melanoma-associated antigen-specific CTL response elicited in HLA-A2/Kb transgenic mice.", J Immunol, vol. 176, issue 4, pp. 2307-15, 2006 Feb 15.
PMID: 16455987
Vingert, B., O. Adotevi, D. Patin, S. Jung, P. Shrikant, L. Freyburger, C. Eppolito, A. Sapoznikov, M. Amessou, F. Quintin-Colonna, et al., "The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity.", Eur J Immunol, vol. 36, issue 5, pp. 1124-35, 2006 May.
PMID: 16568496
Tao, J., B. H. Segal, C. Eppolito, Q. Li, C. G. Dennis, R. Youn, and P. A. Shrikant, "Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity.", J Leukoc Biol, vol. 80, issue 3, pp. 529-37, 2006 Sep.
PMID: 16793916
2004
Pappu, B. P., and P. A. Shrikant, "Alteration of cell surface sialylation regulates antigen-induced naive CD8+ T cell responses.", J Immunol, vol. 173, issue 1, pp. 275-84, 2004 Jul 01.
PMID: 15210785
Moroz, A., C. Eppolito, Q. Li, J. Tao, C. H. Clegg, and P. A. Shrikant, "IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21.", J Immunol, vol. 173, issue 2, pp. 900-9, 2004 Jul 15.
PMID: 15240677
2003
Goldberg, J., P. Shrikant, and M. F. Mescher, "In vivo augmentation of tumor-specific CTL responses by class I/peptide antigen complexes on microspheres (large multivalent immunogen).", J Immunol, vol. 170, issue 1, pp. 228-35, 2003 Jan 01.
PMID: 12496404
2002
Tham, E. Loon, P. Shrikant, and M. F. Mescher, "Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response.", J Immunol, vol. 168, issue 3, pp. 1190-7, 2002 Feb 01.
PMID: 11801654
1999
Shrikant, P., and M. F. Mescher, "Control of syngeneic tumor growth by activation of CD8+ T cells: efficacy is limited by migration away from the site and induction of nonresponsiveness.", J Immunol, vol. 162, issue 5, pp. 2858-66, 1999 Mar 01.
PMID: 10072534
Shrikant, P., A. Khoruts, and M. F. Mescher, "CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.", Immunity, vol. 11, issue 4, pp. 483-93, 1999 Oct.
PMID: 10549630
1996
Shrikant, P., and E. N. Benveniste, "The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.", J Immunol, vol. 157, issue 5, pp. 1819-22, 1996 Sep 01.
PMID: 8757296
1989
Kushwaha, R. S., D. M. Foster, V. N. Murthy, K. D. Carey, and H. C. McGill, "Metabolism of larger high density lipoproteins accumulating in some families of baboons fed a high cholesterol and high saturated fat diet.", J Lipid Res, vol. 30, issue 8, pp. 1147-59, 1989 Aug.
PMID: 2504862