Kristian Doyle, PhD

Associate Professor, Immunobiology
Associate Professor, Neurology
Associate Professor, Psychology
Associate Professor, BIO5 Institute
Associate Professor, Neurosurgery
Associate Professor, Neuroscience-GIDP
Research Scientist, Arizona Center on Aging

Kristian Doyle earned his PhD from Oregon Health & Science University in 2007 developing novel therapeutics for stroke in the laboratory of Dr Mary Stenzel-Poore. Dr Doyle then trained as a Postdoctoral Scholar at Stanford University under the mentorship of Dr Marion Buckwalter researching the role of TGFbeta signaling after stroke and developing a model of post stroke dementia. Dr Doyle started as an Assistant Professor at the University of Arizona in 2013. Dr Doyle was awarded an American Federation of Aging Research Fellowship in 2009, an Anita Roberts Young Scientist Scholarship in 2010, and a K99/R00 faculty transition award from the National Institute of Nursing Research in 2012.

Degrees
  • PhD: Oregon Health & Science University, 2007
  • BS: University of Sussex
Fellowship
  • Stanford University

Recent Publications

2023

Zbesko, J. C., J. Stokes, D. A. Becktel, and K. P. Doyle, "Targeting foam cell formation to improve recovery from ischemic stroke.", Neurobiol Dis, vol. 181, pp. 106130, 2023 Jun 01. PMID: 37068641
Loppi, S. H., M. A. Tavera-Garcia, D. A. Becktel, B. K. Maiyo, K. E. Johnson, T-V. V. Nguyen, R. G. Schnellmann, and K. P. Doyle, "Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke.", J Cereb Blood Flow Metab, vol. 43, issue 7, pp. 1099-1114, 2023 Jul. PMCID: PMC10291449  PMID: 36772984
Loppi, S. H., M. A. Tavera-Garcia, N. E. Scholpa, B. K. Maiyo, D. A. Becktel, H. W. Morrison, R. G. Schnellmann, and K. P. Doyle, "Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain.", Int J Mol Sci, vol. 24, issue 23, 2023 Nov 23. PMCID: PMC10706318  PMID: 38068955

2022

Pederson, W. P., L. M. Ellerman, E. C. Sandoval, S. Boitano, J. B. Frye, K. P. Doyle, H. L. Brooks, F. Polverino, and J. G. Ledford, "Development of a Novel Mouse Model of Menopause-associated Asthma.", Am J Respir Cell Mol Biol, vol. 67, issue 5, pp. 605-609, 2022 Nov. PMCID: PMC9651199  PMID: 36318015
Dwyer, L. J., A. M. Stowe, K. Doyle, P. Popovich, E. Engler-Chiurazzi, C. LeGuern, M. S. Buckwalter, M. C. Poznansky, and R. F. Sîrbulescu, "The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022.", FASEB J, vol. 36, issue 8, pp. e22459, 2022 Aug. PMCID: PMC9337863  PMID: 35857314
Becktel, D. A., J. C. Zbesko, J. B. Frye, A. G. Chung, M. Hayes, K. Calderon, J. W. Grover, A. Li, F. G. Garcia, M. A. Tavera-Garcia, et al., "Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke", Journal of Neuroscience, vol. Jan 42; 2: 325-348, 2022.

2021

Nguyen, T. V., R. H. Crumpacker, K. E. Calderon, F. G. Garcia, J. C. Zbesko, J. B. Frye, S. Gonzalez, D. A. Becktel, T. Yang, M. A. Tavera-Garcia, et al., "Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery", Journal of Pharmacology and experimental Therapeutics, vol. JPET-AR-2021-000711, 2021.
Zbesko, J.C., J.B. Frye, D.A. Becktel, D.K. Gerardo, J. Stokes, K. Calderon, T.V. Nguyen, D. Bhattacharya, and K.P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke", Brain Behavior and Immunity, vol. 91, 2021.
Hoyer-Kimura, C., J.P. Konhilas, H.M. Mansour, R. Polt, K.P. Doyle, D. Billheimer, and M. Hay, "Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia.", Journal of Neuroinflammation, vol. 18(1), 10/2021.

2020

Zbesko, J. C., J. Beischel Frye, D. A. Becktel, D. K. Gerardo, J. Stokes, K. Calderon, T-V. V. Nguyen, D. Bhattacharya, and K. P. Doyle, "IgA natural antibodies are produced following T-cell independent B-cell activation following stroke.", Brain Behav Immun, 2020 Sep 18. PMID: 32956832