Kristian Doyle, PhD
Professor, Immunobiology
Professor, Neurology
Professor, Psychology
Professor, BIO5 Institute
Professor, Neurosurgery
Professor, Neuroscience-GIDP
Research Scientist, Arizona Center on Aging
Professor, Neurology
Professor, Psychology
Professor, BIO5 Institute
Professor, Neurosurgery
Professor, Neuroscience-GIDP
Research Scientist, Arizona Center on Aging
Kristian Doyle earned his PhD from Oregon Health & Science University in 2007 developing novel therapeutics for stroke in the laboratory of Dr Mary Stenzel-Poore. Dr Doyle then trained as a Postdoctoral Scholar at Stanford University under the mentorship of Dr Marion Buckwalter researching the role of TGFbeta signaling after stroke and developing a model of post stroke dementia. Dr Doyle started as an Assistant Professor at the University of Arizona in 2013. Dr Doyle was awarded an American Federation of Aging Research Fellowship in 2009, an Anita Roberts Young Scientist Scholarship in 2010, and a K99/R00 faculty transition award from the National Institute of Nursing Research in 2012.
Degrees
- PhD: Oregon Health & Science University, 2007
- BS: University of Sussex
Fellowship
- Stanford University
Recent Publications
2025
Hashemi, E., I. N. Srivastava, A. Aguirre, E. T. Yoseph, E. Kaushal, A. Awani, J. K. Ryu, K. Akassoglou, S. Talebian, P. Chu, et al., "A Novel Mouse Model for Cerebral Inflammatory Demyelination in X-Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets.", Ann Neurol, vol. 97, issue 2, pp. 296-312, 2025 Feb.
PMCID: PMC11747894 PMID: 39467011
Peterson, I. L., N. E. Scholpa, K. J. Bachtle, J. B. Frye, S. H. Loppi, A. D. Thompson, K. Doyle, T. Marie Largent-Milnes, and R. G. Schnellmann, "Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice.", J Pharmacol Exp Ther, vol. 392, issue 2, pp. 100015, 2025 Feb.
PMCID: PMC12571147 PMID: 40023611
Becktel, D. A., J. B. Frye, E. H. Le, R. G. Schnellmann, and K. P. Doyle, "Plasma Biomarker Profiling of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Treatment in an Aged Mouse Model of Ischemic Stroke.", Int J Mol Sci, vol. 26, issue 22, 2025 Nov 07.
PMCID: PMC12653018 PMID: 41303302
Arizanovska, D., G. F. Bush Iii, C. A. Dallera, O. O. Folorunso, J. B. Frye, K. P. Doyle, J. R. Jagid, H. Wolosker, B. A. Monaco, J. Graciolli Cordeiro, et al., "Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes.", Brain, 2025 Aug 12.
PMID: 40796363
Bartlett, M. J., R. P. Erickson, J. Frye, K. P. Doyle, P. W. Pires, and M. H. Witte, "Manual lymph drainage massage of the head and neck improves cognition and reduces pathological biomarkers in the mouse model of Alzheimers disease.", bioRxiv, 2025 Aug 12.
PMCID: PMC12363786 PMID: 40832216
Brezzo, G., K. A. Zera, D. E. Straus, J. E. Goertz, S. H. Loppi, R. R. Crumpacker, J. B. Frye, D. A. Becktel, M. Isabel Cuartero, A. García Culebras, et al., "Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study.", J Cereb Blood Flow Metab, pp. 271678X251400241, 2025 Dec 07.
PMCID: PMC12685733 PMID: 41355059
2024
Becktel, D. A., J. B. Frye, E. H. Le, S. A. Whitman, R. G. Schnellmann, H. W. Morrison, and K. P. Doyle, "Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model.", J Lipid Res, vol. 65, issue 9, pp. 100614, 2024 Sep.
PMCID: PMC11399596 PMID: 39098585
Bernard, K., J. A. Mota, P. Wene, M. J. Corenblum, J. L. Saez, M. J. Bartlett, L. M Heien, K. P. Doyle, R. Polt, M. Hay, et al., "The angiotensin (1-7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson's disease through modulation of neuroinflammation.", Exp Neurol, vol. 381, pp. 114926, 2024 Nov.
PMID: 39153685
Murphy, D. P., D. C. Dickson, A. N. Fatema, N. G. Carrasco, K. P. Doyle, T. P. Trouard, and H. W. Morrison, "Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion.", Physiol Rep, vol. 12, issue 12, pp. e16118, 2024 Jun.
PMCID: PMC11194179 PMID: 38923318
Arizanovska, D., C. A. Dallera, O. O. Folorunso, G. F. Bush, J. B. Frye, K. P. Doyle, J. R. Jagid, H. Wolosker, B. A. Monaco, J. Graciolli Cordeiro, et al., "Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes.", bioRxiv, 2024 Aug 14.
PMCID: PMC11360988 PMID: 39211262