John G. Purdy, PhD

Associate Professor, Immunobiology
Associate Professor, Cancer Biology-GIDP
Faculty Fellow, BIO5 Institute

John Purdy earned an undergraduate degree from Pacific University and a Ph.D. from Penn State University College of Medicine. He performed his graduate studies in the biochemistry of assembly retroviral capsid in the laboratory of Drs. Rebecca Craven and John Flanagan. Afterwards he trained in metabolomics at the Lewis-Sigler Institute for Integrative Genomics, Princeton University while working in the laboratories of Drs. Joshua Rabinowitz and Thomas Shenk. He has been a member of the UA faculty since October 2015.

Research Interests: 

All viruses hijack host cell machinery to facilitate their replication. Producing infectious viral progeny relies on host cell metabolic pathways to provide energy and building blocks such as nucleotides, amino acids, and lipids. I am interested in investigating the molecular remodeling of cellular metabolic and lipid environments by viruses. The overall goal of my research in dissecting the complex virus-host metabolism interactions is to guide the development of novel antiviral therapies. 

  • BS: Pacific University
  • PhD: Penn State University College of Medicine
  • Post-doctoral Fellow: Princeton University

Recent Publications


Ganji, R., J. A. Paulo, Y. Xi, I. Kline, J. Zhu, C. S. Clemen, C. C. Weihl, J. G. Purdy, S. P. Gygi, and M. Raman, "The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.", Nat Commun, vol. 14, issue 1, pp. 638, 2023 Feb 06. PMCID: PMC9902492  PMID: 36746962


G, G., H-B. W, A. C,, P. S, C. Pacheco S, P. P, M. E, V. M, K. C, et al., "IFI16 Impacts Metabolic Reprogramming During Human Cytomegalovirus Infection", mBio, vol. 13, issue 3, 2022.


Wise, L. M., Y. Xi, and J. G. Purdy, "Hypoxia-Inducible Factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis.", mBio, vol. 12, issue 2, 2021 03 23. PMCID: PMC8092273  PMID: 33758082
Xi, Y., L. Lindenmayer, I. Kline, J. von Einem, and J. G. Purdy, "Human Cytomegalovirus Uses a Host Stress Response To Balance the Elongation of Saturated/Monounsaturated and Polyunsaturated Very-Long-Chain Fatty Acids.", mBio, vol. 12, issue 3, 2021 05 04. PMCID: PMC8262922  PMID: 33947752
Sweedo, A., L. M. Wise, Y. Roka-Moiia, F. Teran Arce, S. S Saavedra, J. Sheriff, D. Bluestein, M. J. Slepian, and J. G. Purdy, "Shear-Mediated Platelet Activation is Accompanied by Unique Alterations in Platelet Release of Lipids.", Cell Mol Bioeng, vol. 14, issue 6, pp. 597-612, 2021 Dec. PMCID: PMC8630256  PMID: 34900013


Turner, D. L., D. V. Korneev, J. G. Purdy, A. de Marco, and R. A. Mathias, "The host exosome pathway underpins biogenesis of the human cytomegalovirus virion.", Elife, vol. 9, 2020 09 10. PMID: 32910773


Xi, Y., S. Harwood, L. Wise, and J. G. Purdy, "Human Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism.", J Virol, 2019 Aug 07. PMID: 31391267
Passalacqua, K. D., J. G. Purdy, and C. E. Wobus, "The inert meets the living: The expanding view of metabolic alterations during viral pathogenesis.", PLoS Pathog, vol. 15, issue 7, pp. e1007830, 2019 Jul. PMCID: PMC6657903  PMID: 31344128


Leng, S. X., J. Kamil, J. G. Purdy, N. A. Lemmermann, M. J. Reddehase, and F. D. Goodrum, "Recent advances in CMV tropism, latency, and diagnosis during aging.", Geroscience, vol. 39, issue 3, pp. 251-259, 2017 06. PMCID: PMC5505884  PMID: 28681110


Purdy, J. G., T. Shenk, and J. D. Rabinowitz, "Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication.", Cell Rep, vol. 10, issue 8, pp. 1375-85, 2015 Mar 03. PMCID: PMC4354725  PMID: 25732827