Jennifer L Uhrlaub
Assistant Research Scientist and Laboratory Manager
Jennifer Uhrlaub received a BA from McDaniel College and a Master's in Biotechnology from Johns Hopkins University. She has been with the Nikolich Lab since 2005 working on a diverse array of projects to understand immune determinants of increased susceptibility to acute and chronic viral infection with age. One of her favorite things about Tucson is entertaining on her patio in the middle of “winter”.
Recent Publications
2019
Thompson, H. L., M. J. Smithey, J. L. Uhrlaub, I. Jeftić, M. Jergović, S. E. White, N. Currier, A. M. Lang, A. Okoye, B. Park, et al.,
"Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.",
Aging Cell, vol. 18, issue 1, pp. e12865, 2019 Feb.
PMCID: PMC6351843 PMID: 30430748
2018
Deshpande, N. R., J. L. Uhrlaub, S. Sing Way, J. Nikolich-Zugich, and M. S. Kuhns,
"A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.",
PLoS One, vol. 13, issue 6, pp. e0198354, 2018.
PMCID: PMC5986155 PMID: 29864157
2017
Uhrlaub, J. L., M. J. Smithey, and J. Nikolich-Zugich,
"Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.",
J Immunol, vol. 199, issue 2, pp. 403-407, 2017 07 15.
PMCID: PMC5520673 PMID: 28615415
2016
Pugh, J. L., S. A. Foster, A. S. Sukhina, J. Petravic, J. L. Uhrlaub, J. Padilla-Torres, T. Hayashi, K. Nakachi, M. J. Smithey, and J. Nikolich-Zugich,
"Acute systemic DNA damage in youth does not impair immune defense with aging.",
Aging Cell, vol. 15, issue 4, pp. 686-93, 2016 08.
PMCID: PMC4933672 PMID: 27072188
Uhrlaub, J. L., V. Pulko, V. R. DeFilippis, R. Broeckel, D. N. Streblow, G. D. Coleman, B. S. Park, J. F. Lindo, I. Vickers, J. J. Anzinger, et al.,
"Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.",
PLoS Pathog, vol. 12, issue 10, pp. e1005891, 2016 Oct.
PMCID: PMC5063327 PMID: 27736984
2015
Smithey, M. J., J. L. Uhrlaub, G. Li, M. Vukmanovic-Stejic, A. N. Akbar, and J. Nikolich-Zugich,
"Lost in translation: mice, men and cutaneous immunity in old age.",
Biogerontology, vol. 16, issue 2, pp. 203-8, 2015 Apr.
PMID: 25027761
Marandu, T. F., J. D. Oduro, L. Borkner, I. Dekhtiarenko, J. L. Uhrlaub, A. Drabig, A. Kröger, J. Nikolich-Zugich, and L. Cičin-Šain,
"Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.",
J Virol, vol. 89, issue 22, pp. 11715-7, 2015 Nov.
PMCID: PMC4645637 PMID: 26339051
Goldberg, E. L., M. J. Romero-Aleshire, K. R. Renkema, M. S. Ventevogel, W. M. Chew, J. L. Uhrlaub, M. J. Smithey, K. H. Limesand, G. D. Sempowski, H. L. Brooks, et al.,
"Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.",
Aging Cell, vol. 14, issue 1, pp. 130-8, 2015 Feb.
PMCID: PMC4326902 PMID: 25424641
2014
Goldberg, E. L., M. J. Smithey, L. K. Lutes, J. L. Uhrlaub, and J. Nikolich-Zugich,
"Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.",
J Immunol, vol. 193, issue 2, pp. 757-63, 2014 Jul 15.
PMCID: PMC4119820 PMID: 24913978
Pollow, D. P., J. Uhrlaub, M. J. Romero-Aleshire, K. Sandberg, J. Nikolich-Zugich, H. L. Brooks, and M. Hay,
"Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.",
Hypertension, vol. 64, issue 2, pp. 384-90, 2014 Aug.
PMCID: PMC4096042 PMID: 24890822