Jennifer L Uhrlaub

Assistant Research Scientist and Laboratory Manager

Jennifer Uhrlaub received a BA from McDaniel College and a Master's in Biotechnology from Johns Hopkins University. She has been with the Nikolich Lab since 2005 working on a diverse array of projects to understand immune determinants of increased susceptibility to acute and chronic viral infection with age. One of her favorite things about Tucson is entertaining on her patio in the middle of “winter”.  

Recent Publications

2019

Thompson, H. L., M. J. Smithey, J. L. Uhrlaub, I. Jeftić, M. Jergović, S. E. White, N. Currier, A. M. Lang, A. Okoye, B. Park, et al., "Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.", Aging Cell, vol. 18, issue 1, pp. e12865, 2019 Feb. PMCID: PMC6351843  PMID: 30430748

2018

Deshpande, N. R., J. L. Uhrlaub, S. Sing Way, J. Nikolich-Zugich, and M. S. Kuhns, "A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.", PLoS One, vol. 13, issue 6, pp. e0198354, 2018. PMCID: PMC5986155  PMID: 29864157

2017

Uhrlaub, J. L., M. J. Smithey, and J. Nikolich-Zugich, "Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.", J Immunol, vol. 199, issue 2, pp. 403-407, 2017 07 15. PMCID: PMC5520673  PMID: 28615415

2016

Pugh, J. L., S. A. Foster, A. S. Sukhina, J. Petravic, J. L. Uhrlaub, J. Padilla-Torres, T. Hayashi, K. Nakachi, M. J. Smithey, and J. Nikolich-Zugich, "Acute systemic DNA damage in youth does not impair immune defense with aging.", Aging Cell, vol. 15, issue 4, pp. 686-93, 2016 08. PMCID: PMC4933672  PMID: 27072188
Uhrlaub, J. L., V. Pulko, V. R. DeFilippis, R. Broeckel, D. N. Streblow, G. D. Coleman, B. S. Park, J. F. Lindo, I. Vickers, J. J. Anzinger, et al., "Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.", PLoS Pathog, vol. 12, issue 10, pp. e1005891, 2016 Oct. PMCID: PMC5063327  PMID: 27736984

2015

Smithey, M. J., J. L. Uhrlaub, G. Li, M. Vukmanovic-Stejic, A. N. Akbar, and J. Nikolich-Zugich, "Lost in translation: mice, men and cutaneous immunity in old age.", Biogerontology, vol. 16, issue 2, pp. 203-8, 2015 Apr. PMID: 25027761
Marandu, T. F., J. D. Oduro, L. Borkner, I. Dekhtiarenko, J. L. Uhrlaub, A. Drabig, A. Kröger, J. Nikolich-Zugich, and L. Cičin-Šain, "Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.", J Virol, vol. 89, issue 22, pp. 11715-7, 2015 Nov. PMCID: PMC4645637  PMID: 26339051
Goldberg, E. L., M. J. Romero-Aleshire, K. R. Renkema, M. S. Ventevogel, W. M. Chew, J. L. Uhrlaub, M. J. Smithey, K. H. Limesand, G. D. Sempowski, H. L. Brooks, et al., "Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.", Aging Cell, vol. 14, issue 1, pp. 130-8, 2015 Feb. PMCID: PMC4326902  PMID: 25424641

2014

Goldberg, E. L., M. J. Smithey, L. K. Lutes, J. L. Uhrlaub, and J. Nikolich-Zugich, "Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.", J Immunol, vol. 193, issue 2, pp. 757-63, 2014 Jul 15. PMCID: PMC4119820  PMID: 24913978
Pollow, D. P., J. Uhrlaub, M. J. Romero-Aleshire, K. Sandberg, J. Nikolich-Zugich, H. L. Brooks, and M. Hay, "Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.", Hypertension, vol. 64, issue 2, pp. 384-90, 2014 Aug. PMCID: PMC4096042  PMID: 24890822