Jennifer L Uhrlaub
Assistant Research Scientist, Immunobiology
Jennifer Uhrlaub received a BA from McDaniel College and a Masters in Biotechnology from Johns Hopkins University. She has been with the Nikolich Lab since 2005 working on a diverse array of projects to understand immune determinants of increased susceptibility to acute viral infection with age. One of her favorite things about Tucson is entertaining on her patio in the middle of “winter”.
Recent Publications
2018
Deshpande, N. R., J. L. Uhrlaub, S. Sing Way, J. Nikolich-Zugich, and M. S. Kuhns,
"A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.",
PLoS One, vol. 13, issue 6, pp. e0198354, 2018.
PMCID: PMC5986155 PMID: 29864157
2015
Smithey, M. J., J. L. Uhrlaub, G. Li, M. Vukmanovic-Stejic, A. N. Akbar, and J. Nikolich-Zugich,
"Lost in translation: mice, men and cutaneous immunity in old age.",
Biogerontology, vol. 16, issue 2, pp. 203-8, 2015 Apr.
PMID: 25027761
Marandu, T. F., J. D. Oduro, L. Borkner, I. Dekhtiarenko, J. L. Uhrlaub, A. Drabig, A. Kröger, J. Nikolich-Zugich, and L. Cičin-Šain,
"Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.",
J Virol, vol. 89, issue 22, pp. 11715-7, 2015 Nov.
PMCID: PMC4645637 PMID: 26339051
Goldberg, E. L., M. J. Romero-Aleshire, K. R. Renkema, M. S. Ventevogel, W. M. Chew, J. L. Uhrlaub, M. J. Smithey, K. H. Limesand, G. D. Sempowski, H. L. Brooks, et al.,
"Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.",
Aging Cell, vol. 14, issue 1, pp. 130-8, 2015 Feb.
PMCID: PMC4326902 PMID: 25424641
2014
Goldberg, E. L., M. J. Smithey, L. K. Lutes, J. L. Uhrlaub, and J. Nikolich-Zugich,
"Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.",
J Immunol, vol. 193, issue 2, pp. 757-63, 2014 Jul 15.
PMCID: PMC4119820 PMID: 24913978
Pollow, D. P., J. Uhrlaub, M. J. Romero-Aleshire, K. Sandberg, J. Nikolich-Zugich, H. L. Brooks, and M. Hay,
"Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.",
Hypertension, vol. 64, issue 2, pp. 384-90, 2014 Aug.
PMCID: PMC4096042 PMID: 24890822
Wertheimer, A. M., M. S. Bennett, B. Park, J. L. Uhrlaub, C. Martinez, V. Pulko, N. L. Currier, D. Nikolich-Žugich, J. Kaye, and J. Nikolich-Zugich,
"Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.",
J Immunol, vol. 192, issue 5, pp. 2143-55, 2014 Mar 1.
PMCID: PMC3989163 PMID: 24501199
2012
Nikolich-Zugich, J., G. Li, J. L. Uhrlaub, K. R. Renkema, and M. J. Smithey,
"Age-related changes in CD8 T cell homeostasis and immunity to infection.",
Semin Immunol, vol. 24, issue 5, pp. 356-64, 2012 Oct.
PMCID: PMC3480557 PMID: 22554418
Cičin-Šain, L., J. D. Brien, J. L. Uhrlaub, A. Drabig, T. F. Marandu, and J. Nikolich-Zugich,
"Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging.",
PLoS Pathog, vol. 8, issue 8, pp. e1002849, 2012.
PMCID: PMC3420928 PMID: 22916012
Smith, J. L., F. E. Grey, J. L. Uhrlaub, J. Nikolich-Zugich, and A. J. Hirsch,
"Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors.",
J Virol, vol. 86, issue 9, pp. 5278-87, 2012 May.
PMCID: PMC3347395 PMID: 22345437