Anthony Bosco

Associate Professor, Immunobiology
Associate Research Scientist
Member of the Graduate Faculty

I was born in 1978 and raised near Fremantle, Western Australia. I completed my BSc (Hons) in Biotechnology at Murdoch University in 2000. I then worked as a research assistant in Patrick G Holt’s laboratory at the Telethon Kids Institute for 1.5 years, before enrolling in a PhD program in the Holt lab to study immunology and genomics. I was awarded my PhD in 2007 from the University of Western Australia. In 2008 I received postdoctoral training with Fernando D Martinez at the Arizona Respiratory Center and BIO5 Institute, the University of Arizona, which is the leading centre for paediatric asthma in the US. I returned to the Telethon Kids Institute in Perth in 2011 where I built the Systems Immunology program over the next 11 years. In October 2021, I co-founded a startup company called Respiradigm Pty Ltd. Respiradigm is developing technologies to predict at birth the propensity for a child to develop asthma. This technology will enable parents to take pre-emptive action to minimise the risk of asthma developing in their child. In November 2021, I founded a new Data Science startup - INSiGENe Pty Ltd. The value proposition of INSiGENe is the GENesis of actionable INSights to unlock disease and novel therapies. In December 2021, I relocated to the University of Arizona to accept a faculty position as Associate Professor Immunobiology (tenure-track), and Associate Research Scientist, Asthma & Airway Disease Research Center (A2DRC).

  • BSc hon (Biotechnology), Murdoch University
  • PhD (Genomics, Immunology), University of Western Australia
Honors and Awards
  • Supporting Research Leaders Scheme, Telethon Kids Institute
  • Discovery Research Award, Telethon Kids Institute
  • Merit Award, Department of Health, Government of Western Australia.
  • Catalyst Leadership Program, University of Western Australia
  • Early Career Research Award for Best Publication, University of Western Australia
  • Postdoc (Genetics, Genomics, Immunology), University of Arizona
  • Fellowship, Simon Lee Foundation
  • Fellowship, Brightspark and McCusker Foundations

Recent Publications


Jones, A. C., J. Leffler, I. A. Laing, J. Bizzintino, S-K. Khoo, P. N. LeSouef, P. D. Sly, P. G. Holt, D. H. Strickland, and A. Bosco, "LPS binding protein and activation signatures are upregulated during asthma exacerbations in children.", Respir Res, vol. 24, issue 1, pp. 184, 2023 Jul 12. PMCID: PMC10337076  PMID: 37438758
M Morales, L. Orozco, C. A. Rinaldi, E. de Jong, S. M. Lansley, Y. C. Gary Lee, R. M. Zemek, A. Bosco, R. A. Lake, and J. W Lesterhuis, "Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.", PLoS One, vol. 18, issue 5, pp. e0274364, 2023. PMCID: PMC10162533  PMID: 37146029
Bosco, A., "Emerging role for interferons in respiratory viral infections and childhood asthma.", Front Immunol, vol. 14, pp. 1109001, 2023. PMCID: PMC9989033  PMID: 36895568
Tu, X., H. M. Gomez, R. Y. Kim, A. C. Brown, E. de Jong, I. Galvao, A. Faiz, A. Bosco, J. C. Horvat, P. Hansbro, et al., "Airway and parenchyma transcriptomics in a house dust mite model of experimental asthma.", Respir Res, vol. 24, issue 1, pp. 32, 2023 Jan 25. PMCID: PMC9878882  PMID: 36698141


Tu, X., R. Y. Kim, A. C. Brown, E. de Jong, B. Jones-Freeman, M. Khadem Ali, H. M. Gomez, K. F. Budden, M. R. Starkey, G. J. M. Cameron, et al., "Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap.", J Allergy Clin Immunol, vol. 150, issue 4, pp. 817-829.e6, 2022 Oct. PMID: 35643377
Zemek, R. M., W. Loong Chin, V. S. Fear, B. Wylie, T. H. Casey, C. Forbes, C. M. Tilsed, L. Boon, B. B. Guo, A. Bosco, et al., "Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice.", Nat Commun, vol. 13, issue 1, pp. 4895, 2022 Aug 19. PMCID: PMC9390963  PMID: 35986006
Read, J. F., M. Serralha, D. Mok, B. J. Holt, M. Cruickshank, Y. V. Karpievitch, D. I. Broadhurst, P. D. Sly, D. H. Strickland, S. N. Reinke, et al., "Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life.", Front Immunol, vol. 13, pp. 876654, 2022. PMCID: PMC9389556  PMID: 35990635
Troy, N. M., D. Strickland, M. Serralha, E. de Jong, A. C. Jones, J. Read, S. Galbraith, Z. Islam, P. Kaur, K. T. Mincham, et al., "Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies.", J Allergy Clin Immunol, vol. 150, issue 1, pp. 93-103, 2022 Jul. PMID: 35177255
Tilsed, C. M., T. H. Casey, E. de Jong, A. Bosco, R. M. Zemek, J. Salmons, G. Wan, M. J. Millward, A. K. Nowak, R. A. Lake, et al., "Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy.", Front Oncol, vol. 12, pp. 849793, 2022. PMCID: PMC8988133  PMID: 35402250
Lee, K. Hung, A. Bosco, M. O'Sullivan, Y. Song, J. Metcalfe, K. Yu, B. J. Mullins, R. Loh, and G. Zhang, "Identifying gene network patterns and associated cellular immune responses in children with or without nut allergy.", World Allergy Organ J, vol. 15, issue 2, pp. 100631, 2022 Feb. PMCID: PMC8844301  PMID: 35228856