Anthony Bosco

Associate Professor, Immunobiology
Associate Research Scientist
Member of the Graduate Faculty

I was born in 1978 and raised near Fremantle, Western Australia. I completed my BSc (Hons) in Biotechnology at Murdoch University in 2000. I then worked as a research assistant in Patrick G Holt’s laboratory at the Telethon Kids Institute for 1.5 years, before enrolling in a PhD program in the Holt lab to study immunology and genomics. I was awarded my PhD in 2007 from the University of Western Australia. In 2008 I received postdoctoral training with Fernando D Martinez at the Arizona Respiratory Center and BIO5 Institute, the University of Arizona, which is the leading centre for paediatric asthma in the US. I returned to the Telethon Kids Institute in Perth in 2011 where I built the Systems Immunology program over the next 11 years. In October 2021, I co-founded a startup company called Respiradigm Pty Ltd. Respiradigm is developing technologies to predict at birth the propensity for a child to develop asthma. This technology will enable parents to take pre-emptive action to minimise the risk of asthma developing in their child. In November 2021, I founded a new Data Science startup - INSiGENe Pty Ltd. The value proposition of INSiGENe is the GENesis of actionable INSights to unlock disease and novel therapies. In December 2021, I relocated to the University of Arizona to accept a faculty position as Associate Professor Immunobiology (tenure-track), and Associate Research Scientist, Asthma & Airway Disease Research Center (A2DRC).

Degrees
  • BSc hon (Biotechnology), Murdoch University
  • PhD (Genomics, Immunology), University of Western Australia
Honors and Awards
  • Supporting Research Leaders Scheme, Telethon Kids Institute
  • Discovery Research Award, Telethon Kids Institute
  • Merit Award, Department of Health, Government of Western Australia.
  • Catalyst Leadership Program, University of Western Australia
  • Early Career Research Award for Best Publication, University of Western Australia
Fellowship
  • Postdoc (Genetics, Genomics, Immunology), University of Arizona
  • Fellowship, Simon Lee Foundation
  • Fellowship, Brightspark and McCusker Foundations

Recent Publications

2025

Alves, E., J. Currenti, K. Crawford, A. Chopra, R. Ram, L. Barnett, J. F. Read, M. Al-Kaabi, I. James, J. M. Carlson, et al., "HIV-1 adapts to HLA class II-associated selection pressure exerted by CD4 and CD8 T cells.", Sci Adv, vol. 11, issue 7, pp. eadr4238, 2025 Feb 14. PMCID: PMC11827868  PMID: 39951541
Palumbo, S., J. Irish, N. Narendran, D. A. Stern, S. Volpe, C. H. Le, R. Starks, A. Bosco, F. D. Martinez, and E. H. Chang, "The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in chronic rhinosinusitis.", J Allergy Clin Immunol, vol. 155, issue 2, pp. 583-593, 2025 Feb. PMCID: PMC11805668  PMID: 39389125
Leffler, J., J. F. Read, D. Mok, M. Serralha, A. Bosco, P. G. Holt, R. Saffery, and D. H. Strickland, "Atopy-related immune profiles are subject to genetic influence as evaluated using school-aged twin pairs.", Sci Adv, vol. 11, issue 29, pp. eads8033, 2025 Jul 18. PMCID: PMC12266113  PMID: 40668915
Sek, K., A. X Y Chen, T. Cole, J. D. Armitage, J. Tong, K. Min Yap, I. Munoz, P. A. Dunbar, S. Wu, M. J. van Elsas, et al., "Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors.", Nat Commun, vol. 16, issue 1, pp. 6123, 2025 Jul 03. PMCID: PMC12229354  PMID: 40610421

2024

Bosco, A., "Novel Role of the GSDMB/IFNG Axis in Childhood Asthma.", Am J Respir Crit Care Med, vol. 209, issue 8, pp. 899-900, 2024 Apr 15. PMCID: PMC11531226  PMID: 38300150
Chin, W. Loong, R. M. Zemek, C. M. Tilsed, A. R. R. Forrest, V. S. Fear, C. Forbes, L. Boon, A. Bosco, B. B. Guo, M. J. Millward, et al., "Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy.", Sci Data, vol. 11, issue 1, pp. 448, 2024 May 03. PMCID: PMC11068878  PMID: 38702329
Ashley, S. E., A. Bosco, and M. L. K. Tang, "Transcriptomic changes associated with oral immunotherapy for food allergy.", Pediatr Allergy Immunol, vol. 35, issue 3, pp. e14106, 2024 Mar. PMID: 38520061

2023

Jones, A. C., J. Leffler, I. A. Laing, J. Bizzintino, S-K. Khoo, P. N. LeSouef, P. D. Sly, P. G. Holt, D. H. Strickland, and A. Bosco, "LPS binding protein and activation signatures are upregulated during asthma exacerbations in children.", Respir Res, vol. 24, issue 1, pp. 184, 2023 Jul 12. PMCID: PMC10337076  PMID: 37438758
M Morales, L. Orozco, C. A. Rinaldi, E. de Jong, S. M. Lansley, Y. C. Gary Lee, R. M. Zemek, A. Bosco, R. A. Lake, and J. W Lesterhuis, "Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.", PLoS One, vol. 18, issue 5, pp. e0274364, 2023. PMCID: PMC10162533  PMID: 37146029
Bosco, A., "Emerging role for interferons in respiratory viral infections and childhood asthma.", Front Immunol, vol. 14, pp. 1109001, 2023. PMCID: PMC9989033  PMID: 36895568