Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.

Smithey MJ, Li G, Venturi V, Davenport MP, Nikolich-Zugich J. "Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life." J Immunol. 2012;189(11):5356-66.