Neurotrophic B cells: tipping the balance toward recovery in the post-stroke brain

The Immunobioloby Seminar Series presents:  "Neurotrophic B Cells:  Tipping the Balance Toward Recovery in the Post-Stroke Brain"

Presenter Details

Ann Stowe, PhD
Professor, Department of Neurology
University of Kentucky

Dr. Stowe's overarching hypothesis is that the immune system – driven by an autoreactivity to CNS-derived antigens – plays a fundamental role in neuronal plasticity within the CNS. B cells, T cells, and natural killer (NK) T cells comprise the adaptive component of the immune system, with their interactions initiated by antigen recognition. In stroke, she hypothesizes that long-term plasticity requires T and B cell responses within the parenchyma, derived from lymphocyte populations sensitized to CNS antigens in the periphery. Her preliminary data show that CD4 and CD8 T cells, as well as B cells, mediate long-term functional recovery and, depending on the responding lymphocyte subset, can directly support neuronal plasticity. Although she uses preclinical studies to investigate the mechanisms by which autoimmune responses affect post-stroke plasticity (e.g., protection from excitotoxicity, dendritic pruning), it is critical to concomitantly confirm and characterize these cells in humans. Her clinical studies into the role of neuroinflammation during brain injury and repair has expanded beyond the field of ischemic stroke to also include subjects with amnestic mild cognitive impairment and pediatric patients on ventilator and hemodynamic support who experience stroke. The combination of preclinical and clinical studies reflects both her own training, which included a clinical postdoctoral fellowship, and her ongoing scientific philosophy that translational research will hasten the collective understanding of functional recovery during and following brain injury.  Read more

imb_seminar_flyer_stowe.pdf