The Immunobiology Seminar Series presents: "Making the Switch - Human Cytomegalovirus Latency and Reactivation"
Presenter Details
Fotini Gounari, PhD
Professor
Department of Immunobiology, Department of Biochemistry and Molecular Biology
Mayo Clinic, Phoenix
Dr. Gounari researches molecular processes of physiologic immune cell development and molecular mechanism of T cell and T-regulatory cell (Treg) plasticity. Studies include the deregulation of immunity in pathologies, including autoimmunity and cancer. The Gounari lab focuses on elucidating epigenetic and transcription regulatory networks that control T cell development and shape a healthy and balanced T cell immunity. T cell maturation involves coordinated changes in the chromatin landscape that enable expression of stage-specific transcription programs. Numerous regulators are essential for T cell development. How these regulators harmonize their actions is poorly understood. A major focus of the lab is understanding the role of the critical T cell-specific DNA-binding protein Tcf-1. Dr. Gounari and her team are exploring its role, along with other regulators, in orchestrating the epigenetic and transcriptional transitions in developing T cells and Tregs. Read more
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