Prabhu S. Arunachalam, PhD

Assistant Professor, Immunobiology
Assistant Professor, BIO5 Institute

Prabhu Arunachalam received his Ph.D. in India and subsequently trained with Prof. Bali Pulendran at Stanford University. Prabhu’s research at the intersection of immunology and vaccinology has defined cooperative immune mechanisms by which the innate and adaptive arms of the immune system synergize to induce durable protection against HIV and SARS-CoV-2 infection. His pioneering work during the COVID-19 pandemic identified human innate immune signatures of SARS-CoV-2 infection and vaccination using a systems immunology approach and contributed to the clinical development of two adjuvanted subunit vaccines



Recent Publications


Arunachalam, P. S., L. Lai, H. Samaha, Y. Feng, M. Hu, H. Sai- Yin Hui, B. Wali, M. Ellis, M. E. Davis-Gardner, C. Huerta, et al., "Durability of immune responses to mRNA booster vaccination against COVID-19.", J Clin Invest, vol. 133, issue 10, 2023 May 15. PMCID: PMC10178835  PMID: 36951954


Pulendran, B., P. S. Arunachalam, and D. T. O'Hagan, "Emerging concepts in the science of vaccine adjuvants.", Nat Rev Drug Discov, vol. 20, issue 6, pp. 454-475, 2021 Jun. PMCID: PMC8023785  PMID: 33824489
Arunachalam, P. S., M. K. D. Scott, T. Hagan, C. Li, Y. Feng, F. Wimmers, L. Grigoryan, M. Trisal, V. Viswanadh Edara, L. Lai, et al., "Systems vaccinology of the BNT162b2 mRNA vaccine in humans.", Nature, vol. 596, issue 7872, pp. 410-416, 2021 Aug. PMCID: PMC8761119  PMID: 34252919


Arunachalam, P. S., F. Wimmers, C. Ka Pun Mok, R. A. P. M. Perera, M. Scott, T. Hagan, N. Sigal, Y. Feng, L. Bristow, O. Tak- Yin Tsang, et al., "Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans.", Science, vol. 369, issue 6508, pp. 1210-1220, 2020 Sep 04. PMCID: PMC7665312  PMID: 32788292
Arunachalam, P. S., T. P. Charles, V. Joag, V. S. Bollimpelli, M. K. D. Scott, F. Wimmers, S. L. Burton, C. C. Labranche, C. Petitdemange, S. Gangadhara, et al., "T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.", Nat Med, vol. 26, issue 6, pp. 932-940, 2020 Jun. PMCID: PMC7303014  PMID: 32393800