Kristian Doyle

Kristian Doyle, PhD

Professor, Immunobiology

Professor, Neurology

Professor, Psychology

Professor, BIO5 Institute

Professor, Neurosurgery

Professor, Neuroscience-GIDP

Research Scientist, Arizona Center on Aging

1656 E. Mabel Street

P.O. Box 245221

Tucson, AZ 85724-5221

Medical Research Building
Suite 214

(520) 626-7013

doylekr@arizona.edu

Links

Doyle Lab

Pubmed

Kristian Doyle earned his PhD from Oregon Health & Science University in 2007 developing novel therapeutics for stroke in the laboratory of Dr Mary Stenzel-Poore. Dr Doyle then trained as a Postdoctoral Scholar at Stanford University under the mentorship of Dr Marion Buckwalter researching the role of TGFbeta signaling after stroke and developing a model of post stroke dementia. Dr Doyle started as an Assistant Professor at the University of Arizona in 2013. Dr Doyle was awarded an American Federation of Aging Research Fellowship in 2009, an Anita Roberts Young Scientist Scholarship in 2010, and a K99/R00 faculty transition award from the National Institute of Nursing Research in 2012.

Degrees

PhD: Oregon Health & Science University, 2007
BS: University of Sussex

Work Experience

Stanford University

Publications

Becktel, Danielle A, Le, Elizabeth H, Frye, Jennifer B, Whitman, Susan A, Schnellmann, Rick G, Doyle, Kristian P. 2-Hydroxypropyl-β-cyclodextrin accesses acute and subacute infarcts in a mouse model of ischemic stroke. Fluids Barriers CNS. Published online January 1, 2026. doi:10.1186/s12987-026-00767-9

Hashemi, Ezzat, Srivastava, Isha N, Aguirre, Alejandro, et al. A Novel Mouse Model for Cerebral Inflammatory Demyelination in X-Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets. Ann Neurol. 2025;97(2):296-312. doi:10.1002/ana.27117

Peterson, Ingrid L, Scholpa, Natalie E, Bachtle, Kiara J, et al. Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice. J Pharmacol Exp Ther. 2025;392(2):100015. doi:10.1124/jpet.124.002171

Brezzo, Gaia, Zera, Kristy A, Straus, Dana E, et al. Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study. J Cereb Blood Flow Metab. Published online January 1, 2025:271678X251400241. doi:10.1177/0271678X251400241

Arizanovska, Dena, Bush Iii, Gerald F, Dallera, Carlos A, et al. Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes. Brain. Published online January 1, 2025. doi:10.1093/brain/awaf293

Bartlett, Mitchell J, Erickson, Robert P, Frye, Jennifer, Doyle, Kristian P, Pires, Paulo W, Witte, Marlys H. Manual lymph drainage massage of the head and neck improves cognition and reduces pathological biomarkers in the mouse model of Alzheimers disease. bioRxiv. Published online January 1, 2025. doi:10.1101/2025.08.08.669361

Becktel, Danielle A, Frye, Jennifer B, Le, Elizabeth H, Schnellmann, Rick G, Doyle, Kristian P. Plasma Biomarker Profiling of 2-Hydroxypropyl-β-Cyclodextrin (HPβCD) Treatment in an Aged Mouse Model of Ischemic Stroke. Int J Mol Sci. 2025;26(22). doi:10.3390/ijms262210814

Bernard, Kelsey, Mota, Jesus A, Wene, Paige, et al. The angiotensin (1-7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson’s disease through modulation of neuroinflammation. Exp Neurol. 2024;381:114926. doi:10.1016/j.expneurol.2024.114926

Becktel, Danielle A, Frye, Jennifer B, Le, Elizabeth H, et al. Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model. J Lipid Res. 2024;65(9):100614. doi:10.1016/j.jlr.2024.100614

Murphy, Devin P, Dickson, Denali C, Fatema, Arisha N, et al. Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion. Physiol Rep. 2024;12(12):e16118. doi:10.14814/phy2.16118

Maiyo, Boaz K, Loppi, Sanna H, Morrison, Helena W, Doyle, Kristian P. Assessment and Quantification of Foam Cells and Lipid Droplet-Accumulating Microglia in Mouse Brain Tissue Using BODIPY Staining. Bio Protoc. 2024;14(21):e5107. doi:10.21769/BioProtoc.5107

Arizanovska, Dena, Dallera, Carlos A, Folorunso, Oluwarotimi O, et al. Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes. bioRxiv. Published online January 1, 2024. doi:10.1101/2024.08.13.607610

Loppi, Sanna H, Tavera-Garcia, Marco A, Becktel, Danielle A, et al. Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery from experimental stroke. J Cereb Blood Flow Metab. 2023;43(7):1099-1114. doi:10.1177/0271678X231157298

Loppi, Sanna H, Tavera-Garcia, Marco A, Scholpa, Natalie E, et al. Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain. Int J Mol Sci. 2023;24(23). doi:10.3390/ijms242316632

Zbesko, Jacob C, Stokes, Jessica, Becktel, Danielle A, Doyle, Kristian P. Targeting foam cell formation to improve recovery from ischemic stroke. Neurobiol Dis. 2023;181:106130. doi:10.1016/j.nbd.2023.106130

Pederson, William P, Ellerman, Laurie M, Sandoval, Estevan C, et al. Development of a Novel Mouse Model of Menopause-associated Asthma. Am J Respir Cell Mol Biol. 2022;67(5):605-609. doi:10.1165/rcmb.2022-0181LE

Dwyer, Liam J, Stowe, Ann M, Doyle, Kristian, et al. The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022. FASEB J. 2022;36(8):e22459. doi:10.1096/fj.202201027

Bartlett, Mitchell J, Flores, Andrew J, Ye, Tony, et al. Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia. Exp Neurol. 2020;333:113413. doi:10.1016/j.expneurol.2020.113413

Zbesko, Jacob C, Frye, Jennifer Beischel, Becktel, Danielle A, et al. IgA natural antibodies are produced following T-cell independent B-cell activation following stroke. Brain Behav Immun. Published online January 1, 2020. doi:10.1016/j.bbi.2020.09.014

Hay, Meredith, Polt, Robin, Heien, Michael L, et al. A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction. J Pharmacol Exp Ther. 2019;369(1):9-25. doi:10.1124/jpet.118.254854

Doyle, Kristian P, Buckwalter, Marion S. Immunological mechanisms in poststroke dementia. Curr Opin Neurol. Published online January 1, 2019. doi:10.1097/WCO.0000000000000783

Nguyen, Thuy-Vi V, Hayes, Megan, Zbesko, Jacob C, et al. Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. Acta Neuropathol Commun. 2018;6(1):100. doi:10.1186/s40478-018-0603-4

Zbesko, Jacob C, Nguyen, Thuy-Vi V, Yang, Tao, et al. Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts. Neurobiol Dis. 2018;112:63-78. doi:10.1016/j.nbd.2018.01.007

Felix, Krysta M, Jaimez, Ivan A, Nguyen, Thuy-Vi V, et al. Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag Mice. Front Cell Infect Microbiol. 2018;8:118. doi:10.3389/fcimb.2018.00118

Chung, Amanda G, Frye, Jennifer B, Zbesko, Jacob C, et al. Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism. eNeuro. 2018;5(5). doi:10.1523/ENEURO.0076-18.2018