Why do some individuals suffer severe illness from infections, while others experience minimal to no symptoms? Why do some individuals respond poorly to vaccination than others? Arunachalam lab addresses the immunological basis of these questions using cutting-edge multiomic approaches to improve “immune equity” across global populations. We do this by:
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Immune profiling of human volunteers with conditions that alter the baseline state of the healthy immune system
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Identifying distinct immune signatures associated with the altered baseline states using computational approaches
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Understanding the mechanistic underpinnings of these immune signatures using complementary tissue culture and animal models
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Developing innovative strategies to improve health outcomes in vulnerable populations
