Publications

2019

Palmer, J., V. Pandit, M. Zeeshan, N. Kulvatunyou, M. Hamidi, K. Hanna, M. Fain, J. Nikolich-Zugich, E-R. Zakaria, and B. Joseph, "The Acute Inflammatory Response after Trauma is heightened by Frailty: A Prospective Evaluation of Inflammatory and Endocrine System Alterations in Frailty.", J Trauma Acute Care Surg, 2019 Feb 13. PMID: 30768559
Thompson, H. L., M. J. Smithey, J. L. Uhrlaub, I. Jeftić, M. Jergović, S. E. White, N. Currier, A. M. Lang, A. Okoye, B. Park, et al., "Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.", Aging Cell, vol. 18, issue 1, pp. e12865, 2019 Feb. PMCID: PMC6351843  PMID: 30430748
Hamidi, M., M. Zeeshan, V. Leon-Risemberg, J. Nikolich-Zugich, K. Hanna, N. Kulvatunyou, A. Tawab Saljuqi, M. Fain, and B. Joseph, "Frailty as a prognostic factor for the critically ill older adult trauma patients.", Am J Surg, 2019 Feb 22. PMID: 30833015
Pollow, D. P., J. A. Uhlorn, M. A. Sylvester, M. Jill Romero-Aleshire, J. L. Uhrlaub, M. L. Lindsey, J. Nikolich-Zugich, and H. L. Brooks, "Menopause and FOXP3 Treg cell depletion eliminate female protection against T cell-mediated Angiotensin II hypertension.", Am J Physiol Heart Circ Physiol, 2019 May 17. PMID: 31099612
Jergović, M., J. L. Uhrlaub, N. A. Contreras, and J. Nikolich-Zugich, "Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?", Geroscience, vol. 41, issue 2, pp. 155-163, 2019 Apr. PMID: 31069636
Jergović, M., N. A. Contreras, and J. Nikolich-Zugich, "Impact of CMV upon immune aging: facts and fiction.", Med Microbiol Immunol, 2019 Apr 19. PMID: 31004198

2018

Davies, J. S., H. L. Thompson, V. Pulko, J. Padilla Torres, and J. Nikolich-Zugich, "Role of Cell-Intrinsic and Environmental Age-Related Changes in Altered Maintenance of Murine T Cells in Lymphoid Organs.", J Gerontol A Biol Sci Med Sci, vol. 73, issue 8, pp. 1018-1026, 2018 Jul 09. PMCID: PMC6037132  PMID: 28582491
Nikolich-Zugich, J., "Author Correction: The twilight of immunity: emerging concepts in aging of the immune system.", Nat Immunol, vol. 19, issue 10, pp. 1146, 2018 Oct. PMID: 30177814
Hayashi, T., H. E. Lynch, S. Geyer, K. Yoshida, K. Furudoi, K. Sasaki, Y. Morishita, H. Nagamura, M. Maki, Y. Hu, et al., "Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort.", Vaccine, vol. 36, issue 45, pp. 6650-6659, 2018 10 29. PMID: 30274868
Hamidi, M., M. Zeeshan, T. O'Keeffe, B. Nisbet, A. Northcutt, J. Nikolich-Zugich, M. Khan, N. Kulvatunyou, M. Fain, and B. Joseph, "Prospective evaluation of frailty and functional independence in older adult trauma patients.", Am J Surg, vol. 216, issue 6, pp. 1070-1075, 2018 Dec. PMID: 30343875
Nikolich-Zugich, J., "The twilight of immunity: emerging concepts in aging of the immune system.", Nat Immunol, vol. 19, issue 1, pp. 10-19, 2018 Jan. PMID: 29242543
Jergović, M., M. J. Smithey, and J. Nikolich-Zugich, "Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging.", Exp Gerontol, vol. 105, pp. 140-145, 2018 05. PMID: 29337070
Contreras, N. A., L. Fontana, V. Tosti, and J. Nikolich-Zugich, "Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.", Geroscience, vol. 40, issue 3, pp. 279-291, 2018 06. PMCID: PMC6060198  PMID: 29804201
Smithey, M. J., V. Venturi, M. P. Davenport, A. S. Buntzman, B. G. Vincent, J. A. Frelinger, and J. Nikolich-Zugich, "Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.", Proc Natl Acad Sci U S A, vol. 115, issue 29, pp. E6817-E6825, 2018 07 17. PMCID: PMC6055168  PMID: 29967140

2017

Uhrlaub, J. L., M. J. Smithey, and J. Nikolich-Zugich, "Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.", J Immunol, vol. 199, issue 2, pp. 403-407, 2017 07 15. PMCID: PMC5520673  PMID: 28615415
Nikolich-Zugich, J., and R. A. W. van Lier, "Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence.", Geroscience, vol. 39, issue 3, pp. 245-249, 2017 06. PMCID: PMC5505886  PMID: 28624867
Thompson, H. L., M. J. Smithey, C. D. Surh, and J. Nikolich-Zugich, "Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma.", Front Immunol, vol. 8, pp. 706, 2017. PMCID: PMC5469916  PMID: 28659930
Metcalf, T. U., P. A. Wilkinson, M. J. Cameron, K. Ghneim, C. Chiang, A. M. Wertheimer, J. B. Hiscott, J. Nikolich-Zugich, and E. K. Haddad, "Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists.", J Immunol, vol. 199, issue 4, pp. 1405-1417, 2017 08 15. PMCID: PMC5548610  PMID: 28696254
Nikolich-Zugich, J., F. Goodrum, K. Knox, and M. J. Smithey, "Known unknowns: how might the persistent herpesvirome shape immunity and aging?", Curr Opin Immunol, vol. 48, pp. 23-30, 2017 Oct. PMCID: PMC5682194  PMID: 28780492
Redeker, A., E. B. M. Remmerswaal, E. T. I. van der Gracht, S. P. M. Welten, T. Höllt, F. Koning, L. Cičin-Šain, J. Nikolich-Zugich, I. J. M. Ten Berge, R. A. W. van Lier, et al., "The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose.", Front Immunol, vol. 8, pp. 1953, 2017. PMCID: PMC5768196  PMID: 29367854
Nikolich-Žugich, J., and J. S. Davies, "Homeostatic migration and distribution of innate immune cells in primary and secondary lymphoid organs with ageing.", Clin Exp Immunol, vol. 187, issue 3, pp. 337-344, 2017 03. PMCID: PMC5290228  PMID: 28035684

2016

Seed, T. M., S. Xiao, N. Manley, J. Nikolich-Zugich, J. Pugh, M. Van den Brink, Y. Hirabayashi, K. Yasutomo, A. Iwama, S. Koyasu, et al., "An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned.", Int J Radiat Biol, vol. 92, issue 2, pp. 59-70, 2016 Feb. PMID: 26857121
Pulko, V., J. S. Davies, C. Martinez, M. C. Lanteri, M. P. Busch, M. S. Diamond, K. Knox, E. C. Bush, P. A. Sims, S. Sinari, et al., "Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses.", Nat Immunol, vol. 17, issue 8, pp. 966-75, 2016 08. PMCID: PMC4955715  PMID: 27270402
Pugh, J. L., S. A. Foster, A. S. Sukhina, J. Petravic, J. L. Uhrlaub, J. Padilla-Torres, T. Hayashi, K. Nakachi, M. J. Smithey, and J. Nikolich-Zugich, "Acute systemic DNA damage in youth does not impair immune defense with aging.", Aging Cell, vol. 15, issue 4, pp. 686-93, 2016 08. PMCID: PMC4933672  PMID: 27072188
Uhrlaub, J. L., V. Pulko, V. R. DeFilippis, R. Broeckel, D. N. Streblow, G. D. Coleman, B. S. Park, J. F. Lindo, I. Vickers, J. J. Anzinger, et al., "Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.", PLoS Pathog, vol. 12, issue 10, pp. e1005891, 2016 Oct. PMCID: PMC5063327  PMID: 27736984

2015

Smithey, M. J., J. L. Uhrlaub, G. Li, M. Vukmanovic-Stejic, A. N. Akbar, and J. Nikolich-Zugich, "Lost in translation: mice, men and cutaneous immunity in old age.", Biogerontology, vol. 16, issue 2, pp. 203-8, 2015 Apr. PMID: 25027761
Nikolich-Zugich, J., D. P. Goldman, P. R. Cohen, D. Cortese, L. Fontana, B. K. Kennedy, J. M Mohler, J. S Olshansky, T. Perls, D. Perry, et al., "Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.", J Gerontol A Biol Sci Med Sci, 2015 Sep 29. PMID: 26419976
Okoye, A. A., M. Rohankhedkar, A. L. Konfe, C. O. Abana, M. D. Reyes, J. A. Clock, D. M. Duell, A. W. Sylwester, P. Sammader, A. W. Legasse, et al., "Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.", J Immunol, vol. 195, issue 9, pp. 4292-305, 2015 Nov 1. PMCID: PMC4617185  PMID: 26416281
Marandu, T. F., J. D. Oduro, L. Borkner, I. Dekhtiarenko, J. L. Uhrlaub, A. Drabig, A. Kröger, J. Nikolich-Zugich, and L. Cičin-Šain, "Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.", J Virol, vol. 89, issue 22, pp. 11715-7, 2015 Nov. PMCID: PMC4645637  PMID: 26339051
Goldberg, E. L., M. J. Romero-Aleshire, K. R. Renkema, M. S. Ventevogel, W. M. Chew, J. L. Uhrlaub, M. J. Smithey, K. H. Limesand, G. D. Sempowski, H. L. Brooks, et al., "Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.", Aging Cell, vol. 14, issue 1, pp. 130-8, 2015 Feb. PMCID: PMC4326902  PMID: 25424641
Metcalf, T. U., R. A. Cubas, K. Ghneim, M. J. Cartwright, J. Van Grevenynghe, J. M. Richner, D. P. Olagnier, P. A. Wilkinson, M. J. Cameron, B. S. Park, et al., "Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors.", Aging Cell, vol. 14, issue 3, pp. 421-32, 2015 Jun. PMCID: PMC4406671  PMID: 25728020

2014

Kusne, Y., E. L. Goldberg, S. S. Parker, S. M. Hapak, I. Y. Maskaykina, W. M. Chew, K. H. Limesand, H. L. Brooks, T. J. Price, N. Sanai, et al., "Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice.", Age (Dordr), vol. 36, issue 1, pp. 199-212, 2014 Feb. PMCID: PMC3889877  PMID: 23949159
Pugh, J. L., A. S. Sukhina, T. M. Seed, N. R. Manley, G. D. Sempowski, M. R. M. van den Brink, M. J. Smithey, and J. Nikolich-Zugich, "Histone deacetylation critically determines T cell subset radiosensitivity.", J Immunol, vol. 193, issue 3, pp. 1451-8, 2014 Aug 1. PMCID: PMC4108568  PMID: 24990082
Goldberg, E. L., M. J. Smithey, L. K. Lutes, J. L. Uhrlaub, and J. Nikolich-Zugich, "Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.", J Immunol, vol. 193, issue 2, pp. 757-63, 2014 Jul 15. PMCID: PMC4119820  PMID: 24913978
Sansoni, P., R. Vescovini, F. F. Fagnoni, A. Akbar, R. Arens, Y-L. Chiu, L. Cičin-Šain, J. Dechanet-Merville, E. Derhovanessian, S. Ferrando-Martinez, et al., "New advances in CMV and immunosenescence.", Exp Gerontol, vol. 55, pp. 54-62, 2014 Jul. PMID: 24703889
Renkema, K. R., G. Li, A. Wu, M. J. Smithey, and J. Nikolich-Zugich, "Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.", J Immunol, vol. 192, issue 1, pp. 151-9, 2014 Jan 1. PMCID: PMC3925780  PMID: 24293630
Nikolich-Zugich, J., "Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories.", J Immunol, vol. 193, issue 6, pp. 2622-9, 2014 Sep 15. PMCID: PMC4157314  PMID: 25193936
Pollow, D. P., J. Uhrlaub, M. J. Romero-Aleshire, K. Sandberg, J. Nikolich-Zugich, H. L. Brooks, and M. Hay, "Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.", Hypertension, vol. 64, issue 2, pp. 384-90, 2014 Aug. PMCID: PMC4096042  PMID: 24890822
M Mohler, J., M. J. Fain, A. M. Wertheimer, B. Najafi, and J. Nikolich-Zugich, "The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals.", Exp Gerontol, vol. 54, pp. 6-13, 2014 Jun. PMID: 24503059
Wertheimer, A. M., M. S. Bennett, B. Park, J. L. Uhrlaub, C. Martinez, V. Pulko, N. L. Currier, D. Nikolich-Žugich, J. Kaye, and J. Nikolich-Zugich, "Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.", J Immunol, vol. 192, issue 5, pp. 2143-55, 2014 Mar 1. PMCID: PMC3989163  PMID: 24501199
Vescovini, R., F. Fausto Fagnoni, A. Rita Telera, L. Bucci, M. Pedrazzoni, F. Magalini, A. Stella, F. Pasin, M. Cristina Medici, A. Calderaro, et al., "Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus.", Age (Dordr), vol. 36, issue 2, pp. 625-40, 2014 Apr. PMCID: PMC4039262  PMID: 24318918

2013

Vukmanovic-Stejic, M., D. Sandhu, T. O. Sobande, E. Agius, K. E. Lacy, N. Riddell, S. Montez, O. B. Dintwe, T. J. Scriba, J. Breuer, et al., "Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans.", J Immunol, vol. 190, issue 3, pp. 977-86, 2013 Feb 1. PMCID: PMC3552094  PMID: 23284056
Rudd, B. D., V. Venturi, N. L. Smith, K. Nzingha, E. L. Goldberg, G. Li, J. Nikolich-Zugich, and M. P. Davenport, "Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses.", PLoS Pathog, vol. 9, issue 9, pp. e1003572, 2013 Sep. PMCID: PMC3771883  PMID: 24068921
Griffiths, S. J., N. E. Riddell, J. Masters, V. Libri, S. M. Henson, A. Wertheimer, D. Wallace, S. Sims, L. Rivino, A. Larbi, et al., "Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.", J Immunol, vol. 190, issue 11, pp. 5363-72, 2013 Jun 1. PMCID: PMC3736312  PMID: 23636061
Lazear, H. M., A. Lancaster, C. Wilkins, M. S. Suthar, A. Huang, S. C. Vick, L. Clepper, L. Thackray, M. M. Brassil, H. W. Virgin, et al., "IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.", PLoS Pathog, vol. 9, issue 1, pp. e1003118, 2013 Jan. PMCID: PMC3536698  PMID: 23300459

2012

Nikolich-Zugich, J., "The aging immune system: challenges for the 21st century.", Semin Immunol, vol. 24, issue 5, pp. 301-2, 2012 Oct. PMCID: PMC3989161  PMID: 23116733
Solana, R., R. Tarazona, A. E. Aiello, A. N. Akbar, V. Appay, M. Beswick, J. A. Bosch, C. Campos, S. Cantisán, L. Cičin-Šain, et al., "CMV and Immunosenescence: from basics to clinics.", Immun Ageing, vol. 9, issue 1, pp. 23, 2012. PMCID: PMC3585851  PMID: 23114110
Li, G., M. J. Smithey, B. D. Rudd, and J. Nikolich-Zugich, "Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium.", Aging Cell, vol. 11, issue 6, pp. 968-77, 2012 Dec. PMCID: PMC3533767  PMID: 22862959
Cičin-Šain, L., J. D. Brien, J. L. Uhrlaub, A. Drabig, T. F. Marandu, and J. Nikolich-Zugich, "Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging.", PLoS Pathog, vol. 8, issue 8, pp. e1002849, 2012. PMCID: PMC3420928  PMID: 22916012
Smithey, M. J., G. Li, V. Venturi, M. P. Davenport, and J. Nikolich-Zugich, "Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.", J Immunol, vol. 189, issue 11, pp. 5356-66, 2012 Dec 1. PMCID: PMC3504138  PMID: 23087407
High, K. P., A. N. Akbar, and J. Nikolich-Zugich, "Translational research in immune senescence: assessing the relevance of current models.", Semin Immunol, vol. 24, issue 5, pp. 373-82, 2012 Oct. PMCID: PMC4018581  PMID: 22633440
Nikolich-Zugich, J., G. Li, J. L. Uhrlaub, K. R. Renkema, and M. J. Smithey, "Age-related changes in CD8 T cell homeostasis and immunity to infection.", Semin Immunol, vol. 24, issue 5, pp. 356-64, 2012 Oct. PMCID: PMC3480557  PMID: 22554418
Smith, J. L., F. E. Grey, J. L. Uhrlaub, J. Nikolich-Zugich, and A. J. Hirsch, "Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors.", J Virol, vol. 86, issue 9, pp. 5278-87, 2012 May. PMCID: PMC3347395  PMID: 22345437

2011

Cičin-Šain, L., A. W. Sylwester, S. I. Hagen, D. C. Siess, N. Currier, A. W. Legasse, M. B. Fischer, C. W. Koudelka, M. K. Axthelm, J. Nikolich-Zugich, et al., "Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques.", J Immunol, vol. 187, issue 4, pp. 1722-32, 2011 Aug 15. PMCID: PMC3151292  PMID: 21765018
Uhrlaub, J. L., J. D. Brien, D. G. Widman, P. W. Mason, and J. Nikolich-Zugich, "Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis.", J Immunol, vol. 186, issue 7, pp. 3882-91, 2011 Apr 1. PMCID: PMC3501996  PMID: 21339368
Rudd, B. D., V. Venturi, M. P. Davenport, and J. Nikolich-Zugich, "Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire.", J Immunol, vol. 186, issue 4, pp. 2056-64, 2011 Feb 15. PMCID: PMC4119821  PMID: 21248263
Smithey, M. J., K. R. Renkema, B. D. Rudd, and J. Nikolich-Zugich, "Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice.", Eur J Immunol, vol. 41, issue 5, pp. 1352-64, 2011 May. PMCID: PMC3517163  PMID: 21469120
Wills, M., A. Akbar, M. Beswick, J. A. Bosch, C. Caruso, G. Colonna-Romano, A. Dutta, C. Franceschi, T. Fulöp, E. Gkrania-Klotsas, et al., "Report from the second cytomegalovirus and immunosenescence workshop.", Immun Ageing, vol. 8, issue 1, pp. 10, 2011. PMCID: PMC3222598  PMID: 22035114
Lang, A., and J. Nikolich-Zugich, "Functional CD8 T cell memory responding to persistent latent infection is maintained for life.", J Immunol, vol. 187, issue 7, pp. 3759-68, 2011 Oct 1. PMCID: PMC4102748  PMID: 21890658

2010

Wertheimer, A. M., J. L. Uhrlaub, A. Hirsch, G. Medigeshi, J. Sprague, A. Legasse, J. Wilk, C. A. Wiley, P. Didier, R. B. Tesh, et al., "Immune response to the West Nile virus in aged non-human primates.", PLoS One, vol. 5, issue 12, pp. e15514, 2010. PMCID: PMC2996299  PMID: 21151986
Nikolich-Zugich, J., and B. D. Rudd, "Immune memory and aging: an infinite or finite resource?", Curr Opin Immunol, vol. 22, issue 4, pp. 535-40, 2010 Aug. PMCID: PMC2925022  PMID: 20674320
Cičin-Šain, L., S. Smyk-Pearson, S. Smyk-Paerson, N. Currier, L. Byrd, C. Koudelka, T. Robinson, G. Swarbrick, S. Tackitt, A. Legasse, et al., "Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.", J Immunol, vol. 184, issue 12, pp. 6739-45, 2010 Jun 15. PMCID: PMC3504654  PMID: 20483749
Rudd, B. D., V. Venturi, M. J. Smithey, S. Sing Way, M. P. Davenport, and J. Nikolich-Zugich, "Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection.", J Immunol, vol. 184, issue 6, pp. 2958-65, 2010 Mar 15. PMCID: PMC4161216  PMID: 20164421