Kristian Doyle

Associate Professor

Kristian Doyle earned his PhD from Oregon Health & Science University in 2007 developing novel therapeutics for stroke in the laboratory of Dr Mary Stenzel-Poore. Dr Doyle then trained as a Postdoctoral Scholar at Stanford University under the mentorship of Dr Marion Buckwalter researching the role of TGFbeta signaling after stroke and developing a model of post stroke dementia. Dr Doyle started as an Assistant Professor at the University of Arizona in 2013. Dr Doyle was awarded an American Federation of Aging Research Fellowship in 2009, an Anita Roberts Young Scientist Scholarship in 2010, and a K99/R00 faculty transition award from the National Institute of Nursing Research in 2012.

Degrees
  • PhD: Oregon Health & Science University, 2007
  • BS: University of Sussex
Fellowship
  • Stanford University

Recent Publications

2019

Hay, M., R. Polt, M. L. Heien, T. W. Vanderah, T. M. Largent-Milnes, K. Rodgers, T. Falk, M. J. Bartlett, K. P. Doyle, and J. P. Konhilas, "A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction.", J Pharmacol Exp Ther, vol. 369, issue 1, pp. 9-25, 2019 Apr. PMCID: PMC6413771  PMID: 30709867

2018

Zbesko, J. C., T-V. V. Nguyen, T. Yang, J. Beischel Frye, O. Hussain, M. Hayes, A. Chung, A. W Day, K. Stepanovic, M. Krumberger, et al., "Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.", Neurobiol Dis, vol. 112, pp. 63-78, 2018 Jan 10. PMID: 29331263
Chung, A. G., J. B. Frye, J. C. Zbesko, E. Constantopoulos, M. Hayes, A. G. Figueroa, D. A. Becktel, A. W Day, J. P. Konhilas, B. S. McKay, et al., "Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PMCID: PMC6223114  PMID: 30417081
Nguyen, T-V. V., M. Hayes, J. C. Zbesko, J. B. Frye, N. R. Congrove, N. P. Belichenko, B. S. McKay, F. M. Longo, and K. P. Doyle, "Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.", Acta Neuropathol Commun, vol. 6, issue 1, pp. 100, 2018 09 24. PMCID: PMC6154927  PMID: 30249297
Taylor, S., E. Mehina, E. White, P. Reeson, K. Yongblah, K. P. Doyle, and C. E. Brown, "Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain.", J Neurosci, vol. 38, issue 40, pp. 8707-8722, 2018 Oct 03. PMID: 30201775
Felix, K. M., I. A. Jaimez, T-V. V. Nguyen, H. Ma, W. A. Raslan, C. N. Klinger, K. P. Doyle, and H-J. J. Wu, "Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag Mice.", Front Cell Infect Microbiol, vol. 8, pp. 118, 2018. PMCID: PMC5932343  PMID: 29755958

2017

Danilo, C. A., E. Constantopoulos, L. A. McKee, H. Chen, J. A. Regan, Y. Lipovka, S. Lahtinen, L. K. Stenman, T-V. V. Nguyen, K. P. Doyle, et al., "Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.", Benef Microbes, vol. 8, issue 2, pp. 257-269, 2017 Apr 26. PMID: 28409534

2016

Nguyen, T-V. V., J. B. Frye, J. C. Zbesko, K. Stepanovic, M. Hayes, A. Urzua, G. Serrano, T. G. Beach, and K. P. Doyle, "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue.", Acta Neuropathol Commun, vol. 4, issue 1, pp. 100, 2016 Sep 06. PMCID: PMC5011964  PMID: 27600707
Doyle, K. P., and M. S. Buckwalter, "Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?", Brain Behav Immun, 2016 Aug 13. PMCID: PMC5305803  PMID: 27531189

2015

Doyle, K. P., L. N. Quach, M. Solé, R. C. Axtell, T-V. V. Nguyen, G. J. Soler-Llavina, S. Jurado, J. Han, L. Steinman, F. M. Longo, et al., "B-Lymphocyte-mediated delayed cognitive impairment following stroke.", J Neurosci, vol. 35, issue 5, pp. 2133-45, 2015 Feb 4. PMCID: PMC4315838  PMID: 25653369