Janko Nikolich-Žugich, MD, PhD

Department Head and Professor, Immunobiology
Co-Director, Arizona Center on Aging
Professor, Medicine
Professor, Nutritional Sciences
Professor, BIO5 Institute
Professor, Genetics-GIDP
Professor, Neuroscience-GIDP

Dr. Nikolich-Žugich is internationally recognized as a leading immunologist and gerontologist. He received his M.D., MSc and Ph.D. in Immunology from Belgrade University School of Medicine. From 1987 to 1990, he worked as a Research Associate at the Scripps Clinic and Research Foundation in the laboratory of Dr. Michael J. Bevan, FRS, NAS, HHMI. In 1990, he joined the Memorial Sloan-Kettering Cancer Center in New York as the Head of both the Flow Cytometry Core Facility and the Laboratory of T Cell Development, first as Assistant and then Associate Member. He served as Assistant Professor (1990-1996) and Associate Professor (1996-2001) at both the Cornell University Graduate School of Medical Sciences and the Division of Molecular Medicine in Cornell University School of Medicine. He was a recipient of the Pew Biomedical Scholar Award and the Louise and Allston Boyer Young Scientist Award.  In 2001, Dr. Nikolich-Žugich assumed the position of Senior Scientist at the Oregon Health & Science University at the Vaccine and Gene Therapy Institute, along with joint appointments as a tenured Professor in the Department of Molecular Microbiology and Immunology and a Senior Scientist at the Oregon National Primate Research Center.  In 2008, Dr. Nikolich-Žugich moved to the University of Arizona to lead the Department of Immunobiology and the Arizona Center on Aging.  His long-term interests include basic mechanisms of T-cell function, immunity to infection in older adults, vaccines and biomarkers of declining immunity in the elderly, immune rejuvenation, immune monitoring in chronic conditions of aging and the impact of inflammation and nutritional intervention in aging, immunity and metabolic disorders.  He has published over 130 scientific papers and reviews describing his work.

Degrees
  • MS: Belgrade University School of Medicine, Serbia
  • PhD: Belgrade University School of Medicine, Serbia
  • MD: Belgrade University School of Medicine, Serbia
Fellowship
  • Post-doctoral Fellow: Scripps Clinic and Research Foundation

Recent Publications

2020

Nikolich-Zugich, J., K. S. Knox, C. Tafich Rios, B. Natt, D. Bhattacharya, and M. J. Fain, "SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes.", Geroscience, vol. 42, issue 2, pp. 505-514, 2020 04. PMCID: PMC7145538  PMID: 32274617
Nikolich-Zugich, J., L. Cičin-Šain, D. Collins-McMillen, S. Jackson, A. Oxenius, J. Sinclair, C. Snyder, M. Wills, and N. Lemmermann, "Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.", Geroscience, vol. 42, issue 2, pp. 495-504, 2020 04. PMCID: PMC7205956  PMID: 32162210
Nikolich-Zugich, J., "Cytomegalovirus and Your Health: Not a Matter of the Heart, Nor of Life and Death.", J Infect Dis, 2020 Sep 10. PMID: 32909616
Ripperger, T. J., J. L. Uhrlaub, M. Watanabe, R. Wong, Y. Castaneda, H. A. Pizzato, M. R. Thompson, C. Bradshaw, C. C. Weinkauf, C. Bime, et al., "Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure.", medRxiv, 2020 Aug 15. PMCID: PMC7430613  PMID: 32817969
Nikolich-Zugich, J., K. S. Knox, C. Tafich Rios, B. Natt, D. Bhattacharya, and M. J. Fain, "Correction to: SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes.", Geroscience, vol. 42, issue 3, pp. 1013, 2020 06. PMCID: PMC7196177  PMID: 32363428

2019

Thompson, H. L., M. J. Smithey, J. L. Uhrlaub, I. Jeftić, M. Jergović, S. E. White, N. Currier, A. M. Lang, A. Okoye, B. Park, et al., "Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.", Aging Cell, vol. 18, issue 1, pp. e12865, 2019 Feb. PMCID: PMC6351843  PMID: 30430748
Hamidi, M., M. Zeeshan, V. Leon-Risemberg, J. Nikolich-Zugich, K. Hanna, N. Kulvatunyou, A. Tawab Saljuqi, M. Fain, and B. Joseph, "Frailty as a prognostic factor for the critically ill older adult trauma patients.", Am J Surg, 2019 Feb 22. PMID: 30833015
Pollow, D. P., J. A. Uhlorn, M. A. Sylvester, M. Jill Romero-Aleshire, J. L. Uhrlaub, M. L. Lindsey, J. Nikolich-Zugich, and H. L. Brooks, "Menopause and FOXP3 Treg cell depletion eliminate female protection against T cell-mediated Angiotensin II hypertension.", Am J Physiol Heart Circ Physiol, 2019 May 17. PMID: 31099612
Jergović, M., J. L. Uhrlaub, N. A. Contreras, and J. Nikolich-Zugich, "Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?", Geroscience, vol. 41, issue 2, pp. 155-163, 2019 Apr. PMID: 31069636
Jergović, M., N. A. Contreras, and J. Nikolich-Zugich, "Impact of CMV upon immune aging: facts and fiction.", Med Microbiol Immunol, 2019 Apr 19. PMID: 31004198