Dominik Schenten, PhD
Assistant Professor, Immunobiology
Dominik Schenten trained for his Ph.D. with Klaus Rajewsky at the University of Cologne and Harvard University, studying the development and function of Germinal Center (GC) B cells. For his post-doctoral training, he joined the laboratory of Ruslan Medzhitov at Yale University, where he studied the mechanisms of innate control of adaptive immunity. He joined the faculty of the University of Arizona in 2013.
Degrees
- MS: Free University of Berlin, Germany, 1998
- PhD: University of Cologne, Germany 2004
Fellowship
- Post-doctoral Fellow: Harvard University, Immunology, 2004-2005
- Post-doctoral Fellow: Yale University, Immunology, 2006-2013
Recent Publications
2018
Sarkar, S., Y. Yuzefpolskiy, H. Xiao, F. M. Baumann, S. Yim, D. J. Lee, D. Schenten, and V. Kalia, "Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals.", J Immunol, vol. 201, issue 12, pp. 3641-3650, 2018 Dec 15.
PMID: 30455400
2014
Pickard, J. M., C. F. Maurice, M. A. Kinnebrew, M. C. Abt, D. Schenten, T. V. Golovkina, S. R. Bogatyrev, R. F. Ismagilov, E. G. Pamer, P. J. Turnbaugh, et al., "Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.", Nature, vol. 514, issue 7524, pp. 638-41, 2014 Oct 30.
PMCID: PMC4214913 PMID: 25274297
Nish, S. A., D. Schenten, T. F Wunderlich, S. D. Pope, Y. Gao, N. Hoshi, S. Yu, X. Yan, H. Kyu Lee, L. Pasman, et al., "T cell-intrinsic role of IL-6 signaling in primary and memory responses.", Elife, vol. 3, pp. e01949, 2014.
PMCID: PMC4046568 PMID: 24842874
Schenten, D., S. A. Nish, S. Yu, X. Yan, H. Kyu Lee, I. Brodsky, L. Pasman, B. Yordy, T. F Wunderlich, J. C. Brüning, et al., "Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.", Immunity, vol. 40, issue 1, pp. 78-90, 2014 Jan 16.
PMCID: PMC4445716 PMID: 24439266
Heger, K., K. Fierens, C. J Vahl, A. Aszodi, K. Peschke, D. Schenten, H. Hammad, R. Beyaert, D. Saur, G. van Loo, et al., "A20-deficient mast cells exacerbate inflammatory responses in vivo.", PLoS Biol, vol. 12, issue 1, pp. e1001762, 2014 Jan.
PMCID: PMC3891641 PMID: 24453940
2013
Palm, N. W., R. K. Rosenstein, S. Yu, D. D. Schenten, E. Florsheim, and R. Medzhitov, "Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.", Immunity, vol. 39, issue 5, pp. 976-85, 2013 Nov 14.
PMCID: PMC3852615 PMID: 24210353
Teichmann, L. L., D. Schenten, R. Medzhitov, M. Kashgarian, and M. J. Shlomchik, "Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus.", Immunity, vol. 38, issue 3, pp. 528-40, 2013 Mar 21.
PMCID: PMC3638041 PMID: 23499488
2012
Hoshi, N., D. Schenten, S. A. Nish, Z. Walther, N. Gagliani, R. A. Flavell, B. Reizis, Z. Shen, J. G. Fox, A. Iwasaki, et al., "MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice.", Nat Commun, vol. 3, pp. 1120, 2012.
PMCID: PMC3521499 PMID: 23047678
Cataisson, C., R. Salcedo, S. Hakim, A. B Moffitt, L. Wright, M. Yi, R. Stephens, R-M. Dai, L. Lyakh, D. Schenten, et al., "IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis.", J Exp Med, vol. 209, issue 9, pp. 1689-702, 2012 Aug 27.
PMCID: PMC3428947 PMID: 22908325
Saribasak, H., R. W. Maul, Z. Cao, W. W. Yang, D. Schenten, S. Kracker, and P. J. Gearhart, "DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.", J Exp Med, vol. 209, issue 6, pp. 1075-81, 2012 Jun 4.
PMCID: PMC3371727 PMID: 22615128