Publications
2023
Ganji, R., J. A. Paulo, Y. Xi, I. Kline, J. Zhu, C. S. Clemen, C. C. Weihl, J. G. Purdy, S. P. Gygi, and M. Raman, "The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.", Nat Commun, vol. 14, issue 1, pp. 638, 2023 Feb 06.
PMCID: PMC9902492 PMID: 36746962
2022
G, G., H-B. W, A. C,, P. S, C. Pacheco S, P. P, M. E, V. M, K. C, et al., "IFI16 Impacts Metabolic Reprogramming During Human Cytomegalovirus Infection", mBio, vol. 13, issue 3, 2022.
2021
Sweedo, A., L. M. Wise, Y. Roka-Moiia, F. Teran Arce, S. S Saavedra, J. Sheriff, D. Bluestein, M. J. Slepian, and J. G. Purdy, "Shear-Mediated Platelet Activation is Accompanied by Unique Alterations in Platelet Release of Lipids.", Cell Mol Bioeng, vol. 14, issue 6, pp. 597-612, 2021 Dec.
PMCID: PMC8630256 PMID: 34900013
Wise, L. M., Y. Xi, and J. G. Purdy, "Hypoxia-Inducible Factor 1α (HIF1α) Suppresses Virus Replication in Human Cytomegalovirus Infection by Limiting Kynurenine Synthesis.", mBio, vol. 12, issue 2, 2021 03 23.
PMCID: PMC8092273 PMID: 33758082
Xi, Y., L. Lindenmayer, I. Kline, J. von Einem, and J. G. Purdy, "Human Cytomegalovirus Uses a Host Stress Response To Balance the Elongation of Saturated/Monounsaturated and Polyunsaturated Very-Long-Chain Fatty Acids.", mBio, vol. 12, issue 3, 2021 05 04.
PMCID: PMC8262922 PMID: 33947752
2020
Turner, D. L., D. V. Korneev, J. G. Purdy, A. de Marco, and R. A. Mathias, "The host exosome pathway underpins biogenesis of the human cytomegalovirus virion.", Elife, vol. 9, 2020 09 10.
PMID: 32910773
2019
Passalacqua, K. D., J. G. Purdy, and C. E. Wobus, "The inert meets the living: The expanding view of metabolic alterations during viral pathogenesis.", PLoS Pathog, vol. 15, issue 7, pp. e1007830, 2019 Jul.
PMCID: PMC6657903 PMID: 31344128
Xi, Y., S. Harwood, L. Wise, and J. G. Purdy, "Human Cytomegalovirus pUL37x1 is Important to Remodeling of Host Lipid Metabolism.", J Virol, 2019 Aug 07.
PMID: 31391267
2017
Leng, S. X., J. Kamil, J. G. Purdy, N. A. Lemmermann, M. J. Reddehase, and F. D. Goodrum, "Recent advances in CMV tropism, latency, and diagnosis during aging.", Geroscience, vol. 39, issue 3, pp. 251-259, 2017 06.
PMCID: PMC5505884 PMID: 28681110
2015
Purdy, J. G., T. Shenk, and J. D. Rabinowitz, "Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication.", Cell Rep, vol. 10, issue 8, pp. 1375-85, 2015 Mar 03.
PMCID: PMC4354725 PMID: 25732827
2014
Hwang, J., J. G. Purdy, K. Wu, J. D. Rabinowitz, and T. Shenk, "Estrogen-related receptor α is required for efficient human cytomegalovirus replication.", Proc Natl Acad Sci U S A, vol. 111, issue 52, pp. E5706-15, 2014 Dec 30.
PMCID: PMC4284536 PMID: 25512541
England, M. R., J. G. Purdy, I. J. Ropson, P. M. Dalessio, and R. C. Craven, "Potential role for CA-SP in nucleating retroviral capsid maturation.", J Virol, vol. 88, issue 13, pp. 7170-7, 2014 Jul.
PMCID: PMC4054415 PMID: 24719425
2013
Grady, S. L., J. G. Purdy, J. D. Rabinowitz, and T. Shenk, "Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection.", Proc Natl Acad Sci U S A, vol. 110, issue 51, pp. E5006-15, 2013 Dec 17.
PMCID: PMC3870743 PMID: 24297925
Koyuncu, E., J. G. Purdy, J. D. Rabinowitz, and T. Shenk, "Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny.", PLoS Pathog, vol. 9, issue 5, pp. e1003333, 2013.
PMCID: PMC3656100 PMID: 23696731
2011
Rabinowitz, J. D., J. G. Purdy, L. Vastag, T. Shenk, and E. Koyuncu, "Metabolomics in drug target discovery.", Cold Spring Harb Symp Quant Biol, vol. 76, pp. 235-46, 2011.
PMCID: PMC4084595 PMID: 22114327
2010
Butan, C., P. M. Lokhandwala, J. G. Purdy, G. Cardone, R. C. Craven, and A. C. Steven, "Suppression of a morphogenic mutant in Rous sarcoma virus capsid protein by a second-site mutation: a cryoelectron tomography study.", J Virol, vol. 84, issue 13, pp. 6377-86, 2010 Jul.
PMCID: PMC2903260 PMID: 20427531
2009
Purdy, J. G., J. M. Flanagan, I. J. Ropson, and R. C. Craven, "Retroviral capsid assembly: a role for the CA dimer in initiation.", J Mol Biol, vol. 389, issue 2, pp. 438-51, 2009 Jun 5.
PMCID: PMC2996723 PMID: 19361521
Cardone, G., J. G. Purdy, N. Cheng, R. C. Craven, and A. C. Steven, "Visualization of a missing link in retrovirus capsid assembly.", Nature, vol. 457, issue 7230, pp. 694-8, 2009 Feb 5.
PMCID: PMC2721793 PMID: 19194444
2008
Purdy, J. G., J. M. Flanagan, I. J. Ropson, K. E. Rennoll-Bankert, and R. C. Craven, "Critical role of conserved hydrophobic residues within the major homology region in mature retroviral capsid assembly.", J Virol, vol. 82, issue 12, pp. 5951-61, 2008 Jun.
PMCID: PMC2395126 PMID: 18400856