Michael S Kuhns

Assistant Professor

Michael Kuhns did his PhD training with James Allison at UC Berkeley studying the role that CTLA-4 plays in regulating CD4 T cell responses. He then went on to Stanford University for his postdoctoral studies with Mark Davis, studying the architecture and function of the TCR-CD3 complex, and joined the Department of Immunobiology at the University of Arizona in 2010. When in search of a mental diversion, he enjoys mountain biking and hiking in the local desert and sky islands.

Degrees
  • BS: University of Arizona
  • PhD: University of California, Berkeley
Fellowship
  • Post-doctoral Fellow: Stanford University

Recent Publications

2016

Parrish, H. L., N. R. Deshpande, J. Vasic, and M. S. Kuhns, "Functional evidence for TCR-intrinsic specificity for MHCII.", Proc Natl Acad Sci U S A, 2016 Feb 1. PMID: 26831112

2015

Parrish, H. L., C. R. Glassman, M. M. Keenen, N. R. Deshpande, M. P. Bronnimann, and M. S. Kuhns, "A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.", PLoS One, vol. 10, issue 7, pp. e0132333, 2015. PMCID: PMC4493003  PMID: 26147390
Lee, M. S., C. R. Glassman, N. R. Deshpande, H. B. Badgandi, H. L. Parrish, C. Uttamapinant, P. S. Stawski, A. Y. Ting, and M. S. Kuhns, "A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.", Immunity, vol. 43, issue 2, pp. 227-39, 2015 Aug 18. PMCID: PMC4545397  PMID: 26231119
Deshpande, N. R., H. L. Parrish, and M. S. Kuhns, "Self-recognition drives the preferential accumulation of promiscuous CD4(+) T-cells in aged mice.", Elife, vol. 4, pp. e05949, 2015. PMCID: PMC4501121  PMID: 26173205

2012

Kuhns, M. S., and H. B. Badgandi, "Piecing together the family portrait of TCR-CD3 complexes.", Immunol Rev, vol. 250, issue 1, pp. 120-43, 2012 Nov. PMID: 23046126
Kuhns, M. S., and M. M. Davis, "TCR Signaling Emerges from the Sum of Many Parts.", Front Immunol, vol. 3, pp. 159, 2012. PMCID: PMC3381686  PMID: 22737151
Zeng, X., Y-L. Wei, J. Huang, E. W. Newell, H. Yu, B. A. Kidd, M. S. Kuhns, R. W. Waters, M. M. Davis, C. T. Weaver, et al., "γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.", Immunity, vol. 37, issue 3, pp. 524-34, 2012 Sep 21. PMCID: PMC3495981  PMID: 22960222

2011

Newell, E. W., L. K. Ely, A. C. Kruse, P. A. Reay, S. N. Rodriguez, A. E. Lin, M. S. Kuhns, C. K Garcia, and M. M. Davis, "Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).", J Immunol, vol. 186, issue 10, pp. 5823-32, 2011 May 15. PMCID: PMC3754796  PMID: 21490152

2010

Kuhns, M. S., A. T. Girvin, L. O. Klein, R. Chen, K. D. C. Jensen, E. W. Newell, J. B. Huppa, B. F. Lillemeier, M. Huse, Y-H. Chien, et al., "Evidence for a functional sidedness to the alphabetaTCR.", Proc Natl Acad Sci U S A, vol. 107, issue 11, pp. 5094-9, 2010 Mar 16. PMCID: PMC2841884  PMID: 20202921

2008

Kuhns, M. S., and M. M. Davis, "The safety on the TCR trigger.", Cell, vol. 135, issue 4, pp. 594-6, 2008 Nov 14. PMCID: PMC2905657  PMID: 19013269