Kristian Doyle

Assistant Professor

Kristian Doyle earned his PhD from Oregon Health & Science University in 2007 developing novel therapeutics for stroke in the laboratory of Dr Mary Stenzel-Poore. Dr Doyle then trained as a Postdoctoral Scholar at Stanford University under the mentorship of Dr Marion Buckwalter researching the role of TGFbeta signaling after stroke and developing a model of post stroke dementia. Dr Doyle started as an Assistant Professor at the University of Arizona in 2013. Dr Doyle was awarded an American Federation of Aging Research Fellowship in 2009, an Anita Roberts Young Scientist Scholarship in 2010, and a K99/R00 faculty transition award from the National Institute of Nursing Research in 2012.

Degrees
  • PhD: Oregon Health & Science University, 2007
  • BS: University of Sussex
Fellowship
  • Stanford University

Recent Publications

2016

Nguyen, T-V. V., J. B. Frye, J. C. Zbesko, K. Stepanovic, M. Hayes, A. Urzua, G. Serrano, T. G. Beach, and K. P. Doyle, "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue.", Acta Neuropathol Commun, vol. 4, issue 1, pp. 100, 2016 Sep 06. PMCID: PMC5011964  PMID: 27600707
Doyle, K. P., and M. S. Buckwalter, "Does B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?", Brain Behav Immun, 2016 Aug 13. PMCID: PMC5305803  PMID: 27531189

2015

Doyle, K. P., L. N. Quach, M. Solé, R. C. Axtell, T-V. V. Nguyen, G. J. Soler-Llavina, S. Jurado, J. Han, L. Steinman, F. M. Longo, et al., "B-Lymphocyte-mediated delayed cognitive impairment following stroke.", J Neurosci, vol. 35, issue 5, pp. 2133-45, 2015 Feb 4. PMCID: PMC4315838  PMID: 25653369
Doyle, K. P., L. N. Quach, H. E. D'Arceuil, and M. S. Buckwalter, "Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice.", Neurosci Lett, vol. 584, pp. 236-40, 2015 Jan 1. PMCID: PMC4268374  PMID: 25449870

2014

Cekanaviciute, E., N. Fathali, K. P. Doyle, A. M. Williams, J. Han, and M. S. Buckwalter, "Astrocytic transforming growth factor-Beta signaling reduces subacute neuroinflammation after stroke in mice.", Glia, vol. 62, issue 8, pp. 1227-40, 2014 Aug. PMCID: PMC4061255  PMID: 24733756

2012

Doyle, K. P., N. Fathali, M. R. Siddiqui, and M. S. Buckwalter, "Distal hypoxic stroke: A new mouse model of stroke with high throughput, low variability and a quantifiable functional deficit.", J Neurosci Methods, vol. 207, issue 1, pp. 31-40, 2012 May 30. PMCID: PMC3348433  PMID: 22465679
Csiszar, A., A. Podlutsky, N. Podlutskaya, W. E. Sonntag, S. Z. Merlin, E. E. R. Philipp, K. Doyle, A. Davila, F. A. Recchia, P. Ballabh, et al., "Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production?", J Gerontol A Biol Sci Med Sci, vol. 67, issue 8, pp. 841-52, 2012 Aug. PMCID: PMC3403864  PMID: 22219516
Pollak, J., K. P. Doyle, L. Mamer, M. Shamloo, and M. S. Buckwalter, "Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.", Brain Behav, vol. 2, issue 5, pp. 698-706, 2012 Sep. PMCID: PMC3489820  PMID: 23139913
Doyle, K. P., and M. S. Buckwalter, "The double-edged sword of inflammation after stroke: what sharpens each edge?", Ann Neurol, vol. 71, issue 6, pp. 729-31, 2012 Jun. PMID: 22718541
Han, J., J. Pollak, T. Yang, M. R. Siddiqui, K. P. Doyle, K. Taravosh-Lahn, E. Cekanaviciute, A. Han, J. Z. Goodman, B. Jones, et al., "Delayed Administration of a Small Molecule Tropomyosin-Related Kinase B Ligand Promotes Recovery After Hypoxic-Ischemic Stroke.", Stroke, vol. 43, issue 7, pp. 1918-24, 2012 Jul. PMCID: PMC3383889  PMID: 22535263