Jeffrey Frelinger

Professor

Jeffrey Frelinger received his BA from the University of California, San Diego, and his PhD from the California Institute of Technology in Pasadena. Following his post-doctoral training at the University of Michigan, he joined the faculty of the University of Southern California. He then moved to the Univeristy of North Carolina, where he later became the chair of the Department of Microbiology Immunology. Jeffrey Frelinger joined the University of Arizona in 2010, where he took a leading role in the management of the ABBS graduate program. He has a longstanding interest in the genetics and biology of major histocompatibility complex (MHC) molecules lab, the development and application of bioinformatic tools for T cell repertoire analysis, as well as the investigation of immune avoidance mechanisms of bacterial pathogens.

Recent Publications

2016

Vincent, B., A. Buntzman, B. Hopson, C. McEwen, L. Cowell, A. Akoglu, H. Zhang, and J. Frelinger, "iWAS - A novel approach to analyzing Next Generation Sequence data for immunology.", Cell Immunol, vol. 299, pp. 6-13, 2016 Jan. PMCID: PMC4698203  PMID: 26547365
Powell, D. A., L. M. Roberts, H. E. Ledvina, G. D. Sempowski, R. Curtiss, and J. A. Frelinger, "Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.", Cell Immunol, vol. 299, pp. 42-9, 2016 Jan. PMCID: PMC4704447  PMID: 26546408

2015

Frelinger, J. A., "Big Data, Big Opportunities, and Big Challenges.", J Investig Dermatol Symp Proc, vol. 17, issue 2, pp. 33-5, 2015 Nov. PMID: 26551943
Kranz, D., A. Ellison, J. A. Frelinger, J. Mackay-Wiggan, and D. A. Norris, "From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata.", J Investig Dermatol Symp Proc, vol. 17, issue 2, pp. 1-5, 2015 Nov. PMID: 26551934
Roberts, L. M., H. E. Ledvina, S. Tuladhar, D. Rana, S. P. Steele, G. D. Sempowski, and J. A. Frelinger, "Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.", Immun Inflamm Dis, vol. 3, issue 2, pp. 71-81, 2015 Jun. PMCID: PMC4444150  PMID: 26029367
Hunsucker, S. A., C. S. McGary, B. G. Vincent, A. A. Enyenihi, J. P. Waugh, K. P. McKinnon, L. M. Bixby, P. A. Ropp, J. M. Coghill, W. A. Wood, et al., "Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire.", Cancer Immunol Res, vol. 3, issue 3, pp. 228-35, 2015 Mar. PMCID: PMC4351150  PMID: 25576336

2014

Roberts, L. M., J. S. Davies, G. D. Sempowski, and J. A. Frelinger, "IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.", Vaccine, vol. 32, issue 29, pp. 3595-603, 2014 Jun 17. PMCID: PMC4075325  PMID: 24837506
Roberts, L. M., S. Tuladhar, S. P. Steele, K. J. Riebe, C-J. Chen, I. R Cumming, S. Seay, R. Frothingham, G. D. Sempowski, T. H. Kawula, et al., "Identification of early interactions between Francisella and the host.", Infect Immun, vol. 82, issue 6, pp. 2504-10, 2014 Jun. PMCID: PMC4019147  PMID: 24686053
Neely, C. J., L. B. Kartchner, A. E. Mendoza, B. M. Linz, J. A. Frelinger, M. C. Wolfgang, R. Maile, and B. A. Cairns, "Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.", PLoS One, vol. 9, issue 1, pp. e85623, 2014. PMCID: PMC3893295  PMID: 24454904
Phillippi, J., Y. Xie, D. R. Miller, T. A. Bell, Z. Zhang, A. B. Lenarcic, D. L. Aylor, S. H. Krovi, D. W. Threadgill, P-M. F de Villena, et al., "Using the emerging Collaborative Cross to probe the immune system.", Genes Immun, vol. 15, issue 1, pp. 38-46, 2014 Jan. PMCID: PMC4004367  PMID: 24195963