Hsin-Jung Joyce Wu, PhD

Assistant Professor

Hsin-Jung Joyce Wu graduated from National Taiwan University with a degree in Veterinary Medicine and obtained her PhD degree from the University of Kentucky, studying B cell signaling. For her post-doctoral training, Jocye Wu joined the lab of Diane Mathis and Christophe Benoist at Harvard University, where she investigated the roles of gut microbiota in autoimmune diseases. She is a faculty member of the University of Arizona since 2011.

Research Interests: 

Dr. Wu's current research includes Dysregulation of Immunity & Inflammation, Immunotherapy & Immune Intervention and Microbial Pathogenesis & Commensalism. These research areas are dedicated to the understanding of how commensal bacteria influence the inflammatory and immune response mediated by autoimmune disease. The goal of this work is focused on exploring the link between gut microbiota, mucosal immunity and autoimmune arthritis.

Degrees
  • PhD: University of Kentucky
  • BS: National Taiwan University
Honors and Awards
  • Center's Scientific Advisory Council, University of Arizona Arthritis Center
Fellowship
  • Harvard University

Recent Publications

2017

Viladomiu, M., C. Kivolowitz, A. Abdulhamid, B. Dogan, D. Victorio, J. G. Castellanos, V. Woo, F. Teng, N. L. Tran, A. Sczesnak, et al., "IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote TH17-dependent inflammation.", Sci Transl Med, vol. 9, issue 376, 2017 Feb 08. PMID: 28179509
Naskar, D., F. Teng, K. M. Felix, P. C Bradley, and H-J. Joyce Wu, "Synthetic Retinoid AM80 Ameliorates Lung and Arthritic Autoimmune Responses by Inhibiting T Follicular Helper and Th17 Cell Responses.", J Immunol, vol. 198, issue 5, pp. 1855-1864, 2017 Mar 01. PMCID: PMC5324833  PMID: 28130500

2016

Teng, F., C. N. Klinger, K. M. Felix, P. C Bradley, E. Wu, N. L. Tran, Y. Umesaki, and H-J. Joyce Wu, "Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells.", Immunity, vol. 44, issue 4, pp. 875-88, 2016 Apr 19. PMID: 27096318
Tan, T. Guan, E. Sefik, N. Geva-Zatorsky, L. Kua, D. Naskar, F. Teng, L. Pasman, A. Ortiz-Lopez, R. Jupp, H-J. Joyce Wu, et al., "Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice.", Proc Natl Acad Sci U S A, vol. 113, issue 50, pp. E8141-E8150, 2016 Dec 13. PMCID: PMC5167147  PMID: 27911839

2012

Wu, H-J., and E. Wu, "The role of gut microbiota in immune homeostasis and autoimmunity.", Gut Microbes, vol. 3, issue 1, pp. 4-14, 2012 Jan-Feb. PMCID: PMC3337124  PMID: 22356853

2011

Kriegel, M. A., E. Sefik, J. A. Hill, H-J. Wu, C. Benoist, and D. Mathis, "Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.", Proc Natl Acad Sci U S A, vol. 108, issue 28, pp. 11548-53, 2011 Jul 12. PMCID: PMC3136249  PMID: 21709219

2010

Wu, H-J., I. I. Ivanov, J. Darce, K. Hattori, T. Shima, Y. Umesaki, D. R. Littman, C. Benoist, and D. Mathis, "Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.", Immunity, vol. 32, issue 6, pp. 815-27, 2010 Jun 25. PMCID: PMC2904693  PMID: 20620945

2009

Wu, H-J., and S. Bondada, "CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function.", J Clin Immunol, vol. 29, issue 1, pp. 12-21, 2009 Jan. PMID: 19067131
Jacobs, J. P., H-J. Wu, C. Benoist, and D. Mathis, "IL-17-producing T cells can augment autoantibody-induced arthritis.", Proc Natl Acad Sci U S A, vol. 106, issue 51, pp. 21789-94, 2009 Dec 22. PMCID: PMC2799826  PMID: 19955422

2007

Wu, H-J., H. Sawaya, B. Binstadt, M. Brickelmaier, A. Blasius, L. Gorelik, U. Mahmood, R. Weissleder, J. Carulli, C. Benoist, et al., "Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.", J Exp Med, vol. 204, issue 8, pp. 1911-22, 2007 Aug 6. PMCID: PMC2118664  PMID: 17646407