Anita A Koshy

Assistant Professor

Anita Koshy obtained her medical degree from Duke University, where she was an HHMI Medical Student Fellow for 2 years. After obtaining her MD, she did clinical training in Neurology and Infectious Disease, before joining the lab of John Boothroyd at Stanford University for her postdoctoral training. In the Boothroyd lab, she established an in vivo system for permanently marking and tracking host cells that have interacted with parasite Toxoplasma gondii

Research Interests: 

Toxoplasma gondii is an intracellular parasite that is found world-wide and is able to infect most warm blooded animals (from birds to humans). In humans and rodents, Toxoplasma naturally establishes a life-long, asymptomatic infection of the brain. Unfortunately, in those with limited immune response (e.g. fetus, organ transplant patients), this tropism for the brain can lead to devastating effects including seizures, blindness, and death. Thus, our goal is to understand the brain-Toxoplasma interaction at the cellular and molecular level so that we can i) develop curative treatment for symptomatic toxoplasmosis and ii) identify new mechanisms for modulating brain immune responses, which are now thought to play a role in neurologic diseases ranging from Multiple Sclerosis to Alzheimer’s disease.

Degrees
  • BS: Stanford University
  • MD: Duke University
Fellowship
  • Infectious Disease Fellowship: Stanford University, 2005-2010
  • Postdoctoral Fellowship: Stanford University, 2007-2012

Recent Publications

2016

Cabral, C. M., S. Tuladhar, H. K. Dietrich, E. Nguyen, W. R. MacDonald, T. Trivedi, A. Devineni, and A. A. Koshy, "Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii.", PLoS Pathog, vol. 12, issue 2, pp. e1005447, 2016 Feb. PMCID: PMC4760770  PMID: 26895155
Hidano, S., L. M. Randall, L. Dawson, H. K. Dietrich, C. Konradt, P. J. Klover, B. John, T. H. Harris, Q. Fang, B. Turek, et al., "STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.", MBio, vol. 7, issue 6, 2016 Nov 08. PMCID: PMC5101356  PMID: 27834206
Konradt, C., N. Ueno, D. A. Christian, J. H. Delong, G. Harms Pritchard, J. Herz, D. J. Bzik, A. A. Koshy, D. B. McGavern, M. B. Lodoen, et al., "Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system.", Nat Microbiol, vol. 1, pp. 16001, 2016 Feb 15. PMCID: PMC4966557  PMID: 27572166

2014

Koshy, A. A., and C. M. Cabral, "3-D imaging and analysis of neurons infected in vivo with Toxoplasma gondii.", J Vis Exp, issue 94, 2014. PMCID: PMC4362681  PMID: 25549001
Dupont, C. D., D. A. Christian, E. M. Selleck, M. Pepper, M. Leney-Greene, G. Harms Pritchard, A. A. Koshy, S. Wagage, M. A. Reuter, D. L Sibley, et al., "Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.", PLoS Pathog, vol. 10, issue 4, pp. e1004047, 2014 Apr. PMCID: PMC3983043  PMID: 24722202
Cekanaviciute, E., H. K. Dietrich, R. C. Axtell, A. M. Williams, R. Egusquiza, K. M. Wai, A. A. Koshy, and M. S. Buckwalter, "Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.", J Immunol, vol. 193, issue 1, pp. 139-49, 2014 Jul 1. PMCID: PMC4075480  PMID: 24860191
Christian, D. A., A. A. Koshy, M. A. Reuter, M. R. Betts, J. C. Boothroyd, and C. A. Hunter, "Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.", Infect Immun, vol. 82, issue 10, pp. 4056-67, 2014 Oct. PMCID: PMC4187868  PMID: 25024368
Blader, I. J., and A. A. Koshy, "Toxoplasma gondii development of its replicative niche: in its host cell and beyond.", Eukaryot Cell, vol. 13, issue 8, pp. 965-76, 2014 Aug. PMCID: PMC4135789  PMID: 24951442
Han, S-J., H. J. Melichar, J. L. Coombes, S. Wei Chan, A. A. Koshy, J. C. Boothroyd, G. M. Barton, and E. A. Robey, "Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.", Immunol Cell Biol, vol. 92, issue 10, pp. 872-81, 2014 Nov. PMCID: PMC4245188  PMID: 25155465

2013

Caffaro, C. E., A. A. Koshy, L. Liu, G. M. Zeiner, C. B. Hirschberg, and J. C. Boothroyd, "A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites.", PLoS Pathog, vol. 9, issue 5, pp. e1003331, 2013. PMCID: PMC3642066  PMID: 23658519