Felicia Goodrum, PhD
Assistant Professor
Contact Information:
Education:
- Wake Forest University School of Medicine 1998 - PhD
- Princeton University - Postdoctoral Fellow
- Virgina Tech - BS
Research:
Human cytomegalovirus (HCMV) is a herpesvirus that persists in 60-99% of the population through a latent infection that results in significant morbidity and mortality following reactivation in individuals with weakened immunity. Latent coexistence is one of the least understood phenomena in virology, but critically important to understanding viral pathogenesis and the impact of viral coexistence on our biology. My research program focuses on identifying the molecular interactions between the virus and the host cell using primary human hematopoietic progenitor cells (HPCs) that culminate in latency. To this end, I have developed a novel in vitro model for HCMV latency and identified the first virus-coded determinant required for latency. We are also exploring the role of cellular mechanisms and pathways that are important to latency. These include the innate immune response to infection and epigenetic regulation of gene expression. Further, we are developing an in vivo model to analyze the impact of latent and productive infection on HPC biology. Identifying virus-host interactions unique to the latent infection will elucidate the mechanisms required for latency and, consequently, those impacting viral pathogenesis.
Publications:
- Petrucelli A, Rak M, Grainger L, and Goodrum F. Characterization of a novel golgi-localized protein of human cytomegalovirus required for latency. J. Virology. Submitted, 2008.
- Goodrum F, Reeves M, Sinclair J, High K, Shenk T. Human cytomegalovirus sequences expressed in latently infected individuals promote a latent infection in vitro. Blood, 110:937-45, Aug 2007
- Ornelles DA, Shepard RN, and Goodrum FD. Analysis of Adenovirus Infections in Synchronized Cells. In: W.S.M. Wold, A.E. Tollefdon eds. Methods in Molecular Medicine, Vol. 131:Adenovirus Methods and Protocols. Totowa: Humana Press;83-102, 2006.
- Goodrum F, Jordan CT, Terhune SS, High K, and Shenk T. Differential Outcomes of Human Cytomegalovirus Infection in Primitive Hematopoietic Subpopulations. Blood, Vol. 104, Issue 3, pp. 687-695, 2004.
- Goodrum FD, Jordan CT, High K, and Shenk T. Human cytomegalovirus gene expression during infection of primary hematopoieitc progentior cells: a model for latency. Proc. Natl. Acad. Sci. Vol. 99, Issue 25, pp.16255-16260, 2002.
- Goodrum F, Jordan CT, Terhune SS, High K, Shenk T. Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. Blood, Vol. 104, pp.687-695, Aug 2004.
- Goodrum FD, Jordan CT, High K, Shenk T. Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: a model for latency. Proc Natl Acad Sci U S A, Vol. 99, pp.16255-16260, Dec 2002.
Peer-reviewed publications
Click here to see a listing of Peer-reviewed publications
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