Infectious Diseases Grand Rounds

Tuesday, March 7, 2017 -
11:00am to 12:00pm

SPEAKER: V.K. Viswanathan, PhD
TITLE: "Microbial Puppetry: Enteropathogenic Escherichia coli manipulates intestinal epithelial cell function"

Speaker bio:
Dr. Viswanathan is an Associate Professor at the School of Animal and Comparative Biomedical sciences, as well as a Joint Associate Professor in the Department of Immunobiology, the Bio5 Institute, and the Department of Veterinary Science and Microbiology at the University of Arizona.  He was named Chair-Elect for the American Society of Microbiology Southwestern Regional Branch (Arizona-Nevada Regional Branch) in the spring of 2016, and won the Outstanding Faculty in Research Award from the Animal and Comparative Biomedical Sciences in the spring of 2016.  Dr. Viswanathan is an Associate Professor at the School of Animal and Comparative Biomedical sciences, as well as a Joint Associate Professor in the Department of Immunobiology, the Bio5 Institute, and the Department of Veterinary Science and Microbiology at the University of Arizona.  He was named Chair-Elect for the American Society of Microbiology Southwestern Regional Branch (Arizona-Nevada Regional Branch) in the spring of 2016, and won the Outstanding Faculty in Research Award from the Animal and Comparative Biomedical Sciences in the spring of 2016.

"The goal of my research program is to investigate the mechanism(s) of gastrointestinal colonization, and intestinal epithelial function perturbations, by bacterial pathogens including enteropathogenic/ enterohemorrhagic E. coli (EPEC/EHEC) and Clostridium difficile. During my 22 years of experience in the fields of microbial physiology, biochemistry, epithelial biology and bacterial pathogenesis, I have authored over 50 publications on various aspects of bacterial virulence and pathogenesis. Currently, I am the PI or Co-PI on ongoing projects related to EPEC-, EHEC- and C. difficile-pathogenesis (funded by the NIH, USDA and VA). The bulk of the preliminary data for this application was generated in my laboratory, with Dr. Vedantam’s laboratory providing support with proteomic analysis and imaging studies. I have the appropriate training and expertise to lead the proposed project focused on detailed mechanistic characterization of EPEC-induced alterations of intestinal epithelial cell death pathways.  My primary contributions to Science include (i) characterization of novel virulence mechanisms of Legionella pneumophila, (ii) dissection of EPEC and EHEC virulence, and concomitant elucidation of novel aspects of intestinal epithelial function, (iii) delineation of Clostridium difficile virulence mechanisms, including the development of a novel therapeutic strategy (iv) Use of innovative approaches to study host-pathogen interactions (novel PCR strategies, proteomics, phospho-proteomics: published and unpublished work) and (v) the authorship of a column in the journal Gut Microbes (Taylor & Francis) which creatively communicates cutting-edge science."

CONTACT: For more information, please email or call Andrew Pritchard or Myrna Seiter, (520) 626-6887.

This University of Arizona event is sponsored by the Division of Infectious Diseases, Department of Medicine, UA College of Medicine - Tucson. It is open to the public, particularly community physicians and other interested health-care professionals.

Event Address: 

University of Arizona College of Medicine - Tucson
1501 N. Campbell Ave., Room 6210
Tucson, AZ 85724