TOPIC: "Why does HIV persist in patients on effective antiviral therapy?"
SPEAKER: Una O’Doherty, MD, an Associate Professor at the University of Pennsylvania and Transfusion Medicine
Dr. O'Doherty began studying HIV in the early 90s while a student in Ralph Steinman’s lab. She has since developed a spinoculation model for HIV latency that is now widely used and has developed robust qPCR-based methods for measuring HIV integration. Her work suggests that the HIV reservoir is not as invisible as is thought - a small subset is expressed at any moment in time, which has important implications for HIV-cure research. She recently proposed a new assay, adapted from a method for rare cancer cell detection, called Fiber-optic Array Scanning Technology (FAST) to identify rare HIV-expressing cells, and preliminary data (submitted for publication) suggests that FAST may provide a high throughput surrogate for measuring replication competent virus, and thus may be used for evaluating HIV eradication studies.
Department of Medicine Grand Rounds
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