 Lonnie P. Lybarger, PhD
Contact Information:
Education:
- Louisiana State University Medical Center, 1999
Research:
MHC class I antigen presentation and the biology of MHC class I molecules:
The research interests of the lab center on the biology of MHC class I molecules, which play a central role in immune responses against both intracellular pathogens and tumors. 1) The first concerns virus-encoded molecules that inhibit MHC class I-restricted antigen presentation. We continue to explore the molecular interactions that are required for mK3 substrate recognition and function. In addition, this system is being used as an entry point to understand ER degradation pathways under normal conditions. 2) The second project centers on the characterization and applications of single-chain versions of class I.
Publications:
- Mitaksov V, Truscott SM, Lybarger L, Connolly JM, Hansen TH, Fremont DH. Structural engineering of pMHC reagents for T cell vaccines and diagnostics. Chem Biol, 14:909-22, Aug 2007.
- Norris HH, Martin AJ, Lybarger LP, Andersen H, Chervenak DC, Chervenak R. TCRbeta enhancer activation in early and late lymphoid progenitors. Cell Immunol, 247:59-71, Jun 2007.
- Wang X, Herr RA, Chua WJ, Lybarger L, Wiertz EJ, Hansen TH.. Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J Cell Biol, 177:613-24, May 2007.
- Truscott SM, Lybarger L, Martinko JM, Mitaksov VE, Kranz DM, Connolly JM, Fremont DH, Hansen TH. Disulfide bond engineering to trap peptides in the MHC class I binding groove. J Immunol, 178:6280-9, May 2007.
- Hansen TH, Lybarger L. Exciting applications of single chain trimers of MHC-I molecules. Cancer Immunol Immunother, 55:235-6 , Feb 2006.
Peer-reviewed publications
Click here to see a listing of Peer-reviewed publications
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