Richard Friedman, PhD
Professor

Contact Information:

• Immunobiology
• Phone: 626-7807
• Fax: 626-2100
• Email: rfriedma@u.arizona.edu
• Faculty Member's BIO5 Webpage Link

Education:

• Michigan State University, 1979.

Research:

Host-parasite Interactions.
Interaction of PMN's and macrophages with bacteria; pathogenesis of bacterial infections and the role of exotoxins, Mycobacterium tuberculosis pathogenesis and molecular biology, Bordetella pertussis ; Molecular mechanisms of bacterial pathogenesis. Studies on bacterial transcriptional regulators. Please see laboratory web site for details: The Friedman Lab Group Homepage

Publications:

• Alteri CJ, Xicohentencatl-Cortes J, Hess S, Caballero-Olin G, Giron JA, and Friedman RL. Mycobacterium tuberculosis produces pili during human infection. 104:5145-5150, 2007.
• Samuel LP, Song CH, Wei J, Roberts EA, Jo EK, and Friedman RL. Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion. Microbiology, 153:529-540, 2007.
• Roberts EA, Clark A, and Friedman RL. Bacterial luciferase is naturally destabilized in Mycobacterium tuberculosis and can be used to monitor changes in gene expression. FEMS Microbiol. Lett. 243:243-249, 2005.
• Roberts EA, Clark A, McBeth S, and Friedman RL. Molecular characterization of the eis promoter of Mycobacterium tuberculosis. J. Bacteriol. 186:5410-5417, 2004.
• Wei, J., J.L. Dahl, J.W. Moulder, E.A. Roberts, P.O'Gaora, D.B. Young and R.L. Friedman. Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages. J. Bacteriology, 182:377-384, 2000.
• Wood, G.E., N. Khelef, N. Guiso and R.L. Friedman. Identification of Btr-regulated genes using a titration assay. Search for a role for this transcriptional regulator in the growth and virulence of Bordetella pertussis. Gene, 209:51-58, 1998.
• Khlef, N., D. DeShazer, R.L. Friedman and N. Guiso. In vivo and in vitro analysis of Bordetella pertussis catalase and Fe-superoxide dismutase mutants. FEMS- Microbiology Letters 142-231-236, 1996.
• DeShazer, D., G.E. Wood, and R.L. Friedman. Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli. J. Bacteriology, 177:3801-3807, 1995.

Peer-reviewed publications

Click here to see a listing of Peer-reviewed publications