Ramireddy Bommireddy, PhD
Contact Information:
Education:
- Indian Institute of Science, 1997.
Research:
TGF beta in Immune regulation and cancer
Self and non-self discrimination by the immune cells is important for protective immune responses against pathogens while preventing self-destructive autoimmune responses. Self-tolerance is achieved during the early stages of individual development both in the thymus (central tolerance) and periphery. Breakdown of peripheral tolerance due to pathogenic infections causes generation of autoreactive T cells which can cause inflammation in a number of tissues leading to autoimmune diseases such as type 1 diabetes, arthritis, multiple sclerosis, autoimmune gastritis, inflammatory bowl syndrome and many others. Using Tgf b 1 knockout mice we have shown that TGF beta 1 prevents T cell activation in response to self-Ag recognition through modulation of activation threshold levels.
Studies are focused toward: (1) understanding the mechanism by which TGF beta 1 prevents T cell activation in response to self-Ag recognition while allowing T cells respond to pathogen infection; (2) understanding the role of TGF beta 1 in regulatory T cell development, maintenance and function; (3) understanding the tumor suppressor role of TGF beta
Publications:
- Bommireddy, R., Babcock, G.F., Singh, R.R., and Doetschman, T. TGF?1-deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function. Clinical Immunology 127: 206-213, 2008.
- Bommireddy, R. and Doetschman, T. TGF?1 and Treg cells: Alliance for Tolerance. Trends Mol Med. 13: 492-501, 2007.
- Bommireddy, R., Pathak, L.J., Martin, J., Ormsby, I., Engle, S.J., Boivin, G.P., Babcock, G.F., Anna U. Eriksson, Singh, R.R., and Doetschman, T. Self-antigen recognition by T cells causes their activation and systemic inflammation in TGF?1-deficient mice. Laboratory Investigation 86: 1008-1019, 2006.
- Bommireddy, R., Engle, S.J., Ormsby, I., Boivin, G.P., Babcock, G.F. and Doetschman, T. Elimination of both CD4+ and CD8+ T cells but not B cells eliminate inflammation and prolong the survival of Tgfb1 null mice. Cellular Immunology 232: 96-104, 2004.
- Bommireddy, R., Ormsby, I., Yin, M., Boivin, G.P., Babcock, G.F. and Doetschman, T. Transforming growth factor beta1 inhibits Ca2+-Calcineurin-mediated activation in thymocytes. Journal of Immunology 170: 3645-3652, 2003.
Peer-reviewed publications
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